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Plasma Phosphorylat...
Plasma Phosphorylated Tau 231 Increases at One-Year Intervals in Cognitively Unimpaired Subjects
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Martinez-Dubarbie, Francisco (author)
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Lopez-Garcia, Sara (author)
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Lage, Carmen (author)
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- Di Molfetta, Guglielmo, 1995 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fernandez-Matarrubia, Marta (author)
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Pozueta-Cantudo, Ana (author)
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Garcia-Martinez, Maria (author)
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Corrales-Pardo, Andrea (author)
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Bravo, Maria (author)
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Jimenez-Bonilla, Julio (author)
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Quirce, Remedios (author)
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Marco de Lucas, Enrique (author)
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Drake-Perez, Marta (author)
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Tordesillas, Diana (author)
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Lopez-Hoyos, Marcos (author)
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Irure-Ventura, Juan (author)
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Valeriano-Lorenzo, Elizabeth (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Rodriguez-Rodriguez, Eloy (author)
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Sanchez-Juan, Pascual (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: JOURNAL OF ALZHEIMERS DISEASE. - 1387-2877 .- 1875-8908. ; 98:3, s. 1029-1042
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Background: Plasma biomarkers of Alzheimer's disease (AD) constitute a non-invasive tool for diagnosing and classifying subjects. They change even in preclinical stages, but it is necessary to understand their properties so they can be helpful in a clinical context. Objective: With this work we want to study the evolution of p-tau231 plasma levels in the preclinical stages of AD and its relationship with both cognitive and imaging parameters. Methods: We evaluated plasma phosphorylated (p)-tau231 levels in 146 cognitively unimpaired subjects in sequential visits. We performed a Linear Mixed-effects Model to analyze their rate of change. We also correlated their baseline levels with cognitive tests and structural and functional image values. ATN status was defined based on cerebrospinal fluid biomarkers. Results: Plasma p-tau231 showed a significant rate of change over time. It correlated negatively with memory tests only in amyloid-positive subjects. No significant correlations were found with any imaging measures. Conclusions: Increases in plasma p-tau231 can be detected at one-year intervals in cognitively healthy subjects. It could constitute a sensitive marker for detecting early signs of neuronal network impairment by amyloid.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- longitudinal study
- p-tau231
- plasma biomarkers
- presymptomatic stages
Publication and Content Type
- ref (subject category)
- art (subject category)
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Martinez-Dubarbi ...
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Lopez-Garcia, Sa ...
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Lage, Carmen
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Di Molfetta, Gug ...
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Fernandez-Matarr ...
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Pozueta-Cantudo, ...
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Garcia-Martinez, ...
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Corrales-Pardo, ...
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Bravo, Maria
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Jimenez-Bonilla, ...
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Quirce, Remedios
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Marco de Lucas, ...
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Drake-Perez, Mar ...
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Tordesillas, Dia ...
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Lopez-Hoyos, Mar ...
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Irure-Ventura, J ...
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Valeriano-Lorenz ...
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Blennow, Kaj, 19 ...
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Ashton, Nicholas ...
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Zetterberg, Henr ...
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Rodriguez-Rodrig ...
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Sanchez-Juan, Pa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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JOURNAL OF ALZHE ...
- By the university
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University of Gothenburg