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Sökning: WFRF:(Persson Patrik) > (2020-2024) > Increased iron abso...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003754naa a2200493 4500
001oai:DiVA.org:uu-414311
003SwePub
008200625s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:143751650
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4143112 URI
0247 a https://doi.org/10.1016/j.cardfail.2020.03.0042 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1437516502 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cabrera, Carin C.u Karolinska Institutet4 aut
2451 0a Increased iron absorption in patients with chronic heart failure and iron deficiency
264 1b Elsevier BV,c 2020
338 a electronic2 rdacarrier
520 a Background: Iron deficiency (ID) is common in patients with chronic heart failure (CHF), but the underlying causes are not fully understood. We investigated whether ID is associated with decreased iron absorption in patients with CHF.Methods and Results: We performed an oral iron-absorption test in 30 patients and 12 controls. The patients had CHF with reduced (n = 15) or preserved (n = 15) ejection fraction and ID, defined as s- ferritin < 100 mu g/L, or s-ferritin 100-299 mu g/L and transferrin saturation < 20%. The controls had no HF or ID and were of similar age and gender. Blood samples were taken before and 2 hours after ingestion of 100 mg ferroglycin sulphate. The primary endpoint was the delta plasma iron at 2 hours. The delta plasma iron was higher in the group with HF than in the control group (median increase 83.8 [61.5;128.5] mu g/dL in HF vs 47.5 [ 30.7;61.5] mu g/dL in controls, P = 0.001), indicating increased iron absorption. There was no significant difference between the groups with preserved or reduced ejection fraction (P = 0.46).Conclusion: We found increased iron absorption in patients with CHF and ID compared to controls without ID and HF, indicating that reduced iron absorption is not a primary cause of the high prevalence of ID in patients with CHF.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Iron deficiency
653 a heart failure
653 a iron absorption
7001 a Ekstrom, Mattiasu Karolinska Institutet4 aut
7001 a Linde, Ceciliau Karolinska Institutet4 aut
7001 a Persson, Hansu Karolinska Institutet4 aut
7001 a Hage, Camillau Karolinska Institutet4 aut
7001 a Eriksson, Maria J.u Karolinska Institutet4 aut
7001 a Wallen, Hakanu Karolinska Institutet4 aut
7001 a Persson, Bengtu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik4 aut0 (Swepub:uu)benpe457
7001 a Tornvall, Peru Karolinska Institutet4 aut
7001 a Lynga, Patriku Karolinska Institutet4 aut
7102 a Karolinska Institutetb Science for Life Laboratory, SciLifeLab4 org
7730 t Journal of Cardiac Failured : Elsevier BVg 26:5, s. 440-443q 26:5<440-443x 1071-9164x 1532-8414
8564 u https://doi.org/10.1016/j.cardfail.2020.03.004y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1447195/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.onlinejcf.com/article/S1071916420301640/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414311
8564 8u https://doi.org/10.1016/j.cardfail.2020.03.004
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143751650

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