Sökning: WFRF:(Persson Patrik) > (2020-2024) > Increased iron abso...
Fältnamn | Indikatorer | Metadata |
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000 | 03754naa a2200493 4500 | |
001 | oai:DiVA.org:uu-414311 | |
003 | SwePub | |
008 | 200625s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:143751650 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4143112 URI |
024 | 7 | a https://doi.org/10.1016/j.cardfail.2020.03.0042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1437516502 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Cabrera, Carin C.u Karolinska Institutet4 aut |
245 | 1 0 | a Increased iron absorption in patients with chronic heart failure and iron deficiency |
264 | 1 | b Elsevier BV,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Background: Iron deficiency (ID) is common in patients with chronic heart failure (CHF), but the underlying causes are not fully understood. We investigated whether ID is associated with decreased iron absorption in patients with CHF.Methods and Results: We performed an oral iron-absorption test in 30 patients and 12 controls. The patients had CHF with reduced (n = 15) or preserved (n = 15) ejection fraction and ID, defined as s- ferritin < 100 mu g/L, or s-ferritin 100-299 mu g/L and transferrin saturation < 20%. The controls had no HF or ID and were of similar age and gender. Blood samples were taken before and 2 hours after ingestion of 100 mg ferroglycin sulphate. The primary endpoint was the delta plasma iron at 2 hours. The delta plasma iron was higher in the group with HF than in the control group (median increase 83.8 [61.5;128.5] mu g/dL in HF vs 47.5 [ 30.7;61.5] mu g/dL in controls, P = 0.001), indicating increased iron absorption. There was no significant difference between the groups with preserved or reduced ejection fraction (P = 0.46).Conclusion: We found increased iron absorption in patients with CHF and ID compared to controls without ID and HF, indicating that reduced iron absorption is not a primary cause of the high prevalence of ID in patients with CHF. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Iron deficiency | |
653 | a heart failure | |
653 | a iron absorption | |
700 | 1 | a Ekstrom, Mattiasu Karolinska Institutet4 aut |
700 | 1 | a Linde, Ceciliau Karolinska Institutet4 aut |
700 | 1 | a Persson, Hansu Karolinska Institutet4 aut |
700 | 1 | a Hage, Camillau Karolinska Institutet4 aut |
700 | 1 | a Eriksson, Maria J.u Karolinska Institutet4 aut |
700 | 1 | a Wallen, Hakanu Karolinska Institutet4 aut |
700 | 1 | a Persson, Bengtu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik4 aut0 (Swepub:uu)benpe457 |
700 | 1 | a Tornvall, Peru Karolinska Institutet4 aut |
700 | 1 | a Lynga, Patriku Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Journal of Cardiac Failured : Elsevier BVg 26:5, s. 440-443q 26:5<440-443x 1071-9164x 1532-8414 |
856 | 4 | u https://doi.org/10.1016/j.cardfail.2020.03.004y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1447195/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.onlinejcf.com/article/S1071916420301640/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414311 |
856 | 4 8 | u https://doi.org/10.1016/j.cardfail.2020.03.004 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143751650 |
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