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Headache in Systemi...
Headache in Systemic Lupus Erythematosus Results From a Prospective, International Inception Cohort Study
- Article/chapterEnglish2013
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LIBRIS-ID:oai:lup.lub.lu.se:0eef268f-78ad-4421-a0dc-3554f7ed8179
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https://lup.lub.lu.se/record/4212543URI
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https://doi.org/10.1002/art.38106DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127620419URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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ObjectiveTo examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE). MethodsA disease inception cohort was assessed annually for headache (5 types) and 18 other neuropsychiatric (NP) events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and Short Form 36 (SF-36) mental and physical component summary scores were collected. Time to first headache and associations with SF-36 scores were analyzed using Cox proportional hazards and linear regression models with generalized estimating equations. ResultsAmong the 1,732 SLE patients enrolled, 89.3% were female and 48.3% were white. The mean SD age was 34.6 +/- 13.4 years, duration of disease was 5.6 +/- 5.2 months, and length of followup was 3.8 +/- 3.1 years. At enrollment, 17.8% of patients had headache (migraine [60.7%], tension [38.6%], intractable nonspecific [7.1%], cluster [2.6%], and intracranial hypertension [1.0%]). The prevalence of headache increased to 58% after 10 years. Only 1.5% of patients had lupus headache, as identified in the SLEDAI-2K. In addition, headache was associated with other NP events attributed to either SLE or non-SLE causes. There was no association of headache with SLEDAI-2K scores (without the lupus headache variable), SDI scores, use of corticosteroids, use of antimalarials, use of immunosuppressive medications, or specific autoantibodies. SF-36 mental component scores were lower in patients with headache compared with those without headache (mean +/- SD 42.5 +/- 12.2 versus 47.8 +/- 11.3; P < 0.001), and similar differences in physical component scores were seen (38.0 +/- 11.0 in those with headache versus 42.6 +/- 11.4 in those without headache; P < 0.001). In 56.1% of patients, the headaches resolved over followup. ConclusionHeadache is frequent in SLE, but overall, it is not associated with global disease activity or specific autoantibodies. Although headaches are associated with a lower HRQOL, the majority of headaches resolve over time, independent of lupus-specific therapies.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Urowitz, Murray B.
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O'Keeffe, Aidan G.
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Gordon, Caroline
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Bae, Sang-Cheol
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Sanchez-Guerrero, Jorge
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Romero-Diaz, Juanita
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Clarke, Ann E.
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Bernatsky, Sasha
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Wallace, Daniel J.
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Ginzler, Ellen M.
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Isenberg, David A.
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Rahman, Anisur
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Merrill, Joan T.
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Petri, Michelle
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Fortin, Paul R.
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Gladman, Dafna D.
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Fessler, Barri J.
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Alarcon, Graciela S.
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Bruce, Ian N.
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Dooley, Mary Anne
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Steinsson, Kristjan
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Khamashta, Munther A.
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Ramsey-Goldman, Rosalind
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Manzi, Susan
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Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst
(author)
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Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni
(author)
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Zoma, Asad A.
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van Vollenhoven, Ronald F.Karolinska Institutet
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Ramos-Casals, Manuel
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, Guillermo
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Kalunian, Kenneth C.
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Lim, S. Sam
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Inanc, Murat
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Kamen, Diane L.
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Peschken, Christine A.
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Jacobsen, Soren
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Theriault, Chris
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Thompson, Kara
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Farewell, Vernon
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Reumatologi och molekylär skelettbiologiSektion III
(creator_code:org_t)
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In:Arthritis and Rheumatism: Wiley65:11, s. 2887-28971529-01310004-3591
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Hanly, John G.
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Urowitz, Murray ...
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O'Keeffe, Aidan ...
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Gordon, Caroline
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Bae, Sang-Cheol
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Sanchez-Guerrero ...
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Romero-Diaz, Jua ...
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Clarke, Ann E.
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Bernatsky, Sasha
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Wallace, Daniel ...
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Ginzler, Ellen M ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Petri, Michelle
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Fortin, Paul R.
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Gladman, Dafna D ...
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Fessler, Barri J ...
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Alarcon, Graciel ...
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Bruce, Ian N.
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Dooley, Mary Ann ...
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Steinsson, Krist ...
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Khamashta, Munth ...
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Ramsey-Goldman, ...
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Manzi, Susan
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Sturfelt, Gunnar
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Nived, Ola
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Zoma, Asad A.
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van Vollenhoven, ...
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Ramos-Casals, Ma ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Kalunian, Kennet ...
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Lim, S. Sam
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Inanc, Murat
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Kamen, Diane L.
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Peschken, Christ ...
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Jacobsen, Soren
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Theriault, Chris
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Thompson, Kara
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Farewell, Vernon
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Arthritis and Rh ...
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Lund University
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Karolinska Institutet