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High-avidity IgA pr...
High-avidity IgA protects the intestine by enchaining growing bacteria
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- Moor, Kathrin (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.;Univ Zurich, Ctr Dent Med, Zurich, Switzerland.
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- Diard, Mederic (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Sellin, Mikael E. (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Felmy, Boas (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Wotzka, Sandra Y. (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Toska, Albulena (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Bakkeren, Erik (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Arnoldini, Markus (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Bansept, Florence (författare)
- CNRS UPMC, Lab Jean Perrin, UMR 8237, F-75005 Paris, France.
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- Dal Co, Alma (författare)
- ETH, Dept Environm Syst Sci, Zurich, Switzerland.;Swiss Fed Inst Aquat Sci & Technol, Eawag, Dept Environm Microbiol, Dubendorf, Switzerland.
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- Voller, Tom (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Minola, Andrea (författare)
- Humabs BioMed SA, CH-6500 Bellinzona, Switzerland.
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- Fernandez-Rodriguez, Blanca (författare)
- Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland.
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- Agatic, Gloria (författare)
- Humabs BioMed SA, CH-6500 Bellinzona, Switzerland.
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- Barbieri, Sonia (författare)
- Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland.
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- Piccoli, Luca (författare)
- Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland.
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- Casiraghi, Costanza (författare)
- Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland.;Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy.
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- Corti, Davide (författare)
- Humabs BioMed SA, CH-6500 Bellinzona, Switzerland.
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- Lanzavecchia, Antonio (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.;Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland.
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- Regoes, Roland R. (författare)
- ETH, Inst Integrat Biol, CH-8092 Zurich, Switzerland.
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- Loverdo, Claude (författare)
- CNRS UPMC, Lab Jean Perrin, UMR 8237, F-75005 Paris, France.
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- Stocker, Roman (författare)
- ETH, Dept Civil Environm & Geomat Engn, Inst Environm Engn, CH-8093 Zurich, Switzerland.
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- Brumley, Douglas R. (författare)
- ETH, Dept Civil Environm & Geomat Engn, Inst Environm Engn, CH-8093 Zurich, Switzerland.;Univ Melbourne, Sch Math & Stat, Parkville, Vic 3010, Australia.
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- Hardt, Wolf-Dietrich (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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- Slack, Emma (författare)
- ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
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ETH, Inst Microbiol, CH-8093 Zurich, Switzerland;Univ Zurich, Ctr Dent Med, Zurich, Switzerland. ETH, Inst Microbiol, CH-8093 Zurich, Switzerland. (creator_code:org_t)
- 2017-04-12
- 2017
- Engelska.
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 544:7651, s. 498-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly neutralizing virulence factors or by poorly defined mechanisms that physically impede bacterial interactions with the gut tissues ('immune exclusion')(1-3). IgA-mediated cross-linking clumps bacteria in the gut lumen and is critical for protection against infection by non-typhoidal Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium). However, classical agglutination, which was thought to drive this process, is efficient only at high pathogen densities (>= 10(8) non-motile bacteria per gram). In typical infections, much lower densities(4,5) (10(0)-10(7) colony-forming units per gram) of rapidly dividing bacteria are present in the gut lumen. Here we show that a different physical process drives formation of clumps in vivo: IgA-mediated cross-linking enchains daughter cells, preventing their separation after division, and clumping is therefore dependent on growth. Enchained growth is effective at all realistic pathogen densities, and accelerates pathogen clearance from the gut lumen. Furthermore, IgA enchains plasmid-donor and -recipient clones into separate clumps, impeding conjugative plasmid transfer in vivo. Enchained growth is therefore a mechanism by which IgA can disarm and clear potentially invasive species from the intestinal lumen without requiring high pathogen densities, inflammation or bacterial killing. Furthermore, our results reveal an untapped potential for oral vaccines in combating the spread of antimicrobial resistance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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Nature
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Till lärosätets databas
- Av författaren/redakt...
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Moor, Kathrin
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Diard, Mederic
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Sellin, Mikael E ...
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Felmy, Boas
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Wotzka, Sandra Y ...
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Toska, Albulena
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visa fler...
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Bakkeren, Erik
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Arnoldini, Marku ...
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Bansept, Florenc ...
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Dal Co, Alma
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Voller, Tom
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Minola, Andrea
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Fernandez-Rodrig ...
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Agatic, Gloria
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Barbieri, Sonia
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Piccoli, Luca
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Casiraghi, Costa ...
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Corti, Davide
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Lanzavecchia, An ...
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Regoes, Roland R ...
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Loverdo, Claude
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Stocker, Roman
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Brumley, Douglas ...
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Hardt, Wolf-Diet ...
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Slack, Emma
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