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  • Blomqvist, Mia E-L (author)

Towards compendia of negative genetic association studies: an example for Alzheimer disease.

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • 2005-12-08
  • Springer Science and Business Media LLC,2006

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/62051
  • https://gup.ub.gu.se/publication/62051URI
  • https://doi.org/10.1007/s00439-005-0078-9DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1956281URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Most genetic sequence variants that contribute to variability in complex human traits will have small effects that are not readily detectable with population samples typically used in genetic association studies. A potentially valuable tool in the gene discovery process is meta-analysis of the accumulated published data, but in order to be valid these require a sample of studies representative of the true genetic effect and thus hypothetically should include some positive and an abundance of negative reports. A survey of the literature on association studies for Alzheimer disease (AD) from January 2004-April 2005, identified 138 studies, 86 of which reported positive findings other than for apolipoprotein E (APOE), strongly indicative of publication bias. We report here an analysis of 62 genetic markers, tested for association with AD risk as well as for possible effects upon quantitative indices of AD severity (mini-mental state examination scores, age-at-onset, and cerebrospinal fluid (CSF) beta-amyloid (Abeta) and CSF tau proteins). Within this set, only modest signals were present that, with the exception of APOE are easily lost when corrections for multiple hypotheses are applied. In isolation, results are thus broadly negative. Genes studied encompass both novel candidates as well as several recently claimed to be associated with AD (e.g. urokinase plasminogen activator (PLAU) and acetyl-coenzyme A acetyltransferase 1 (ACAT1)). By reporting these data we hope to encourage the publication of gene compendia to guide further studies and aid future meta-analyses aimed at resolving the involvement of genes in complex human traits.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Reynolds, Chandra (author)
  • Katzov, Hagit (author)
  • Feuk, Lars (author)
  • Andreasen, NielsKarolinska Institutet (author)
  • Bogdanovic, NenadKarolinska Institutet (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Brookes, Anthony J (author)
  • Prince, Jonathan AKarolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Human genetics: Springer Science and Business Media LLC119:1-2, s. 29-370340-67171432-1203

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