Sökning: WFRF:(Rifas Shiman Sheryl) > Multi-ancestry geno...
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000 | 07487naa a2201153 4500 | |
001 | oai:lup.lub.lu.se:6183ba7b-3d2b-4a89-8014-4f75405582aa | |
003 | SwePub | |
008 | 220812s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/6183ba7b-3d2b-4a89-8014-4f75405582aa2 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddac0502 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Pervjakova, Nataliau Tartu University Hospital4 aut |
245 | 1 0 | a Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes |
264 | c 2022-02-26 | |
264 | 1 | b Oxford University Press (OUP),c 2022 |
520 | a Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy (GenDIP) Consortium assembled genome-wide association studies (GWAS) of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. Through multi-ancestry meta-analysis, we identified five loci with genome-wide significant association (p < 5x10-8) with GDM, mapping to/near MTNR1B (p = 4.3x10-54), TCF7L2 (p = 4.0x10-16), CDKAL1 (p = 1.6 × 10-14), CDKN2A-CDKN2B (p = 4.1x10-9) and HKDC1 (p = 2.9x10-8). Multiple lines of evidence pointed to the shared pathophysiology of GDM and T2D: (i) four of the five GDM loci (not HKDC1) have been previously reported at genome-wide significance for T2D; (ii) significant enrichment for associations with GDM at previously reported T2D loci; (iii) strong genetic correlation between GDM and T2D; and (iv) enrichment of GDM associations mapping to genomic annotations in diabetes-relevant tissues and transcription factor binding sites. Mendelian randomisation analyses demonstrated significant causal association (5% false discovery rate) of higher body mass index on increased GDM risk. Our results provide support for the hypothesis that GDM and T2D are part of the same underlying pathology but that, as exemplified by the HKDC1 locus, there are genetic determinants of GDM that are specific to glucose regulation in pregnancy. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Moen, Gunn-Helenu University of Oslo4 aut |
700 | 1 | a Borges, Maria-Carolinau University of Bristol4 aut |
700 | 1 | a Ferreira, Teresau University of Oxford4 aut |
700 | 1 | a Cook, James Pu University of Liverpool4 aut |
700 | 1 | a Allard, Catherineu Sherbrooke University4 aut |
700 | 1 | a Beaumont, Robin Nu University of Exeter4 aut |
700 | 1 | a Canouil, Mickaëlu Pasteur Institute of Lille4 aut |
700 | 1 | a Hatem, Gadu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)ga5503ha |
700 | 1 | a Heiskala, Anniu University of Oulu4 aut |
700 | 1 | a Joensuu, Anniu Finnish National Institute for Health and Welfare4 aut |
700 | 1 | a Karhunen, Villeu University of Oulu4 aut |
700 | 1 | a Kwak, Soo Heon4 aut |
700 | 1 | a Lin, Frederick T J4 aut |
700 | 1 | a Liu, Jun4 aut |
700 | 1 | a Rifas-Shiman, Sheryl4 aut |
700 | 1 | a Tam, Claudia H4 aut |
700 | 1 | a Tam, Wing Hung4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Andrew, Toby4 aut |
700 | 1 | a Auvinen, Juha4 aut |
700 | 1 | a Bhowmik, Bishwajit4 aut |
700 | 1 | a Bonnefond, Amélie4 aut |
700 | 1 | a Delahaye, Fabien4 aut |
700 | 1 | a Demirkan, Ayse4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Haller-Kikkatalo, Kadri4 aut |
700 | 1 | a Hardardottir, Hildur4 aut |
700 | 1 | a Hummel, Sandra4 aut |
700 | 1 | a Hussain, Akhtar4 aut |
700 | 1 | a Kajantie, Eero4 aut |
700 | 1 | a Keikkala, Elina4 aut |
700 | 1 | a Khamis, Amna4 aut |
700 | 1 | a Lahti, Jari4 aut |
700 | 1 | a Lekva, Tove4 aut |
700 | 1 | a Mustaniemi, Sanna4 aut |
700 | 1 | a Sommer, Christine4 aut |
700 | 1 | a Tagoma, Aili4 aut |
700 | 1 | a Tzala, Evangelia4 aut |
700 | 1 | a Uibo, Raivou University of Tartu4 aut0 (Swepub:lu)med-ruo |
700 | 1 | a Vääräsmäki, Marja4 aut |
700 | 1 | a Villa, Pia M4 aut |
700 | 1 | a Birkeland, Kåre I4 aut |
700 | 1 | a Bouchard, Luigi4 aut |
700 | 1 | a Duijn, Cornelia M4 aut |
700 | 1 | a Finer, Sarah4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Hämäläinen, Esa4 aut |
700 | 1 | a Hayes, Geoffrey M4 aut |
700 | 1 | a Hitman, Graham A4 aut |
700 | 1 | a Jang, Hak C4 aut |
700 | 1 | a Järvelin, Marjo-Riitta4 aut |
700 | 1 | a Jenum, Anne Karen4 aut |
700 | 1 | a Laivuori, Hannele4 aut |
700 | 1 | a Ma, Ronald C4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Oken, Emily4 aut |
700 | 1 | a Park, Kyong Soo4 aut |
700 | 1 | a Perron, Patrice4 aut |
700 | 1 | a Prasad, Rashmi Bu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)med-rpa |
700 | 1 | a Qvigstad, Elisabeth4 aut |
700 | 1 | a Sebert, Sylvain4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
700 | 1 | a Tuomi, Tiinamaijau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Helsinki University Central Hospital,Folkhälsan Research Center,University of Helsinki4 aut0 (Swepub:lu)ti8736tu |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Franks, Paul Wu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University4 aut0 (Swepub:lu)med-plf |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Lindgren, Cecilia Mu Broad Institute,University of Oxford4 aut0 (Swepub:lu)endo-cli |
700 | 1 | a Freathy, Rachel M4 aut |
700 | 1 | a Lawlor, Deborah A4 aut |
700 | 1 | a Morris, Andrew P4 aut |
700 | 1 | a Mägi, Reedik4 aut |
710 | 2 | a Tartu University Hospitalb University of Oslo4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 31:19, s. 3377-3391q 31:19<3377-3391x 0964-6906x 1460-2083 |
856 | 4 | u http://dx.doi.org/10.1093/hmg/ddac050x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/6183ba7b-3d2b-4a89-8014-4f75405582aa |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddac050 |
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