Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples.

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Fältnamn	Indikatorer	Metadata
000		04677naa a2200409 4500
001		oai:DiVA.org:uu-318105
003		SwePub
008		170323s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3181052 URI
024	7	a https://doi.org/10.1016/j.jpba.2016.12.0122 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kip, A Eu Slotervaart Hosp, Antoni van Leeuwenhoek Hosp, Dept Pharm & Pharmacol, POB 90440, NL-1006 BK Amsterdam, Netherlands.; Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Univ Weg 99, NL-3584 CG Utrecht, Netherlands4 aut
245	1 0	a Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples.
264	1	b Elsevier BV,c 2017
338		a print2 rdacarrier
520		a Miltefosine is an oral agent against the neglected tropical disease leishmaniasis, which is mostly endemic in resource-poor areas. Dried blood spot (DBS) sampling is an attractive alternative to plasma sampling for pharmacokinetic studies in these remote areas, but introduces additional variability in analyte quantification due to possible blood spot inhomogeneity and variability in blood spot volume and haematocrit values. Volumetric absorptive microsampling (VAMS) potentially overcomes a few of these issues as the VAMS device absorbs a fixed volume that is processed as a whole. We developed and validated an LC-MS/MS method for the quantification of miltefosine with this novel sampling technique with good performance in terms of linearity, selectivity, accuracy (bias within ±10.8%), precision (CV%≤11.9%), recovery, carry-over and matrix effect. VAMS samples were stable for at least one month at room temperature and 37°C. The impact of haematocrit on assay accuracy was reduced compared to conventional DBS sampling, but indicated a declining recovery with increased haematocrit due to haematocrit dependency in recovery from the sampling device. A clinical validation will be required to investigate whether VAMS is an appropriate and cost-effective alternative sampling method to conventional DBS sampling.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653		a Bioanalysis
653		a Dried blood
653		a Hematocrit
653		a LC–MS/MS
653		a Miltefosine
653		a Volumetric absorptive microsampling (VAMS)
700	1	a Kiers, K Cu Slotervaart Hosp, Antoni van Leeuwenhoek Hosp, Dept Pharm & Pharmacol, POB 90440, NL-1006 BK Amsterdam, Netherlands4 aut
700	1	a Rosing, Hu Slotervaart Hosp, Antoni van Leeuwenhoek Hosp, Dept Pharm & Pharmacol, POB 90440, NL-1006 BK Amsterdam, Netherlands4 aut
700	1	a Schellens, J H Mu Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Univ Weg 99, NL-3584 CG Utrecht, Netherlands.; Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Clin Pharmacol, POB 90203, NL-1006 BE Amsterdam, Netherlands4 aut
700	1	a Beijnen, J Hu Slotervaart Hosp, Antoni van Leeuwenhoek Hosp, Dept Pharm & Pharmacol, POB 90440, NL-1006 BK Amsterdam, Netherlands.; Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Univ Weg 99, NL-3584 CG Utrecht, Netherlands.; Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Clin Pharmacol, POB 90203, NL-1006 BE Amsterdam, Netherlands4 aut
700	1	a Dorlo, Thomas P Cu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Univ Weg 99, NL-3584 CG Utrecht, Netherlands4 aut0 (Swepub:uu)thodo249
710	2	a Slotervaart Hosp, Antoni van Leeuwenhoek Hosp, Dept Pharm & Pharmacol, POB 90440, NL-1006 BK Amsterdam, Netherlands.; Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Univ Weg 99, NL-3584 CG Utrecht, Netherlandsb Slotervaart Hosp, Antoni van Leeuwenhoek Hosp, Dept Pharm & Pharmacol, POB 90440, NL-1006 BK Amsterdam, Netherlands4 org
773	0	t Journal of Pharmaceutical and Biomedical Analysisd : Elsevier BVg 135, s. 160-166q 135<160-166x 0731-7085x 1873-264X
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318105
856	4 8	u https://doi.org/10.1016/j.jpba.2016.12.012

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