WFRF:(Rozema T)
Search: WFRF:(Rozema T) > Significant salivar...
- 3 of 10
- Previous record
- Next record
- To hitlist
Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation
- van Leeuwen, S. J. M. (author)
- Proctor, G. B. (author)
- Laheij, Amga (author)
- show more...
- Potting, C. M. J. (author)
- Smits, O. (author)
- Bronkhorst, E. M. (author)
- Hazenberg, M. D. (author)
- Haverman, T. M. (author)
- Brennan, M. T. (author)
- Raber-Durlacher, J. E. (author)
- Huysmans, Mcdnjm (author)
- Rozema, F. R. (author)
- Blijlevens, N. M. A. (author)
- show less...
- (creator_code:org_t)
- 2021-01-08
- 2021
- English.
- In: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365.
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The aim of this multicentre, longitudinal study was to determine salivary changes in relation to oral mucositis (OM) in multiple myeloma patients following high-dose melphalan and autologous hematopoietic stem cell transplantation (ASCT). Unstimulated and stimulated whole-mouth saliva samples (UWS and SWS) were collected before ASCT, 1x/wk during the hospitalisation phase, and 3 and 12 months post-ASCT. During the hospitalisation period OM was scored 3x/wk (WHO system). Flow rate, pH, total protein concentration (Nanodrop), albumin, lactoferrin, neutrophil defensin-1 (HNP1), total IgA and S100A8/A9 (ELISA) were determined. Mixed models were used to evaluate differences between ulcerative (u)OM (>= 2 WHO, n = 20) and non-uOM (n = 31) groups. Until 18 days after ASCT, flow rate, pH, total IgA and HNP1 levels decreased in UWS and/or SWS, while log lactoferrin levels were significantly increased (UWS: p = 0.016 95% CI [0.36, 3.58], SWS: p < 0.001 95% CI [1.14, 3.29]). Twelve months post-ASCT, salivary protein levels were similar to baseline except for log total IgA, which was higher (UWS: p < 0.001 95% CI [0.49, 1.29], SWS: p < 0.001 95% CI [0.72, 1.45]). No differences between uOM and non-uOM groups were observed. Changes in salivary proteins indicated an inflammatory reaction in salivary glands coinciding with mucosal and systemic reactions in response to high-dose melphalan.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- high-dose melphalan
- myeloma patients
- lactoferrin
- mucosal
- complications
- calprotectin
- chemotherapy
- expression
- proteins
- therapy
- Biophysics
- Oncology
- Hematology
- Immunology
- Transplantation
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Bone Marrow Transplantation (Search for host publication in LIBRIS)
To the university's database
- 3 of 10
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- van Leeuwen, S. ...
- Proctor, G. B.
- Laheij, Amga
- Potting, C. M. J ...
- Smits, O.
- Bronkhorst, E. M ...
- show more...
- Hazenberg, M. D.
- Haverman, T. M.
- Brennan, M. T.
- von Bültzingslöw ...
- Raber-Durlacher, ...
- Huysmans, Mcdnjm
- Rozema, F. R.
- Blijlevens, N. M ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Dentistry
- Articles in the publication
- Bone Marrow Tran ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
