Long-term prognosis after a first myocardial infarction: eight years follow up of the case-control study PAROKRANK

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Long-term prognosis after a first myocardial infarction : eight years follow up of the case-control study PAROKRANK

Ferrannini, Giulia (author): Karolinska Institutet,Karolinska Institute

Almosawi, Mariam (author): Karolinska Institute

Buhlin, Kare (author): Karolinska Institutet,Karolinska Institute

De Faire, Ulf (author): Karolinska Institute

Kjellström, Barbro (author): Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital

Klinge, Björn (author): Karolinska Institutet,Malmö University,Karolinska Institute,Malmö universitet,Odontologiska fakulteten (OD),Section of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Nygren, Ake (author): Karolinska Inst, Danderyds Hosp, Dept Clin Sci, Stockholm, Sweden.,Department of Clinical Sciences, Danderyds Hospital, Karolinska Institutet, Stockholm, Sweden

Näsman, Per, Docent, 1954- (author): KTH Royal Institute of Technology,KTH,Centrum för trafikforskning, CTR,Center for Safety Research, KTH Royal Institute of Technology, Stockholm, Sweden

Svenungsson, Elisabet (author): Karolinska Institutet

Ryden, Lars (author): Karolinska Institutet,Karolinska Institute

Norhammar, Anna (author): Karolinska Institutet,Karolinska Institute,Capio St. Görans Sjukhus

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2022-08-16
2022
English.
In: Scandinavian Cardiovascular Journal. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 56:1, s. 337-342

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Journal article (peer-reviewed)

Abstract Subject headings

Objective. To explore long-term cardiovascular outcomes and mortality in patients after a first myocardial infarction (MI) compared with matched controls in a contemporary setting. Methods. During 2010-2014 the Swedish study PAROKRANK recruited 805 patients <75 years with a first MI and 805 age-, gender-, and area-matched controls. All study participants were followed until 31 December 2018, through linkage with the National Patient Registry and the Cause of Death Registry. The primary endpoint was the first of a composite of all-cause death, non-fatal MI, non-fatal stroke, and heart failure hospitalization. Event rates in cases and controls were calculated using a Cox regression model, subsequently adjusted for baseline smoking, education level, and marital status. Kaplan-Meier curves were computed and compared by log-rank test. Results. A total of 804 patients and 800 controls (mean age 62 years; women 19%) were followed for a mean of 6.2 (0.2-8.5) years. The total number of primary events was 211. Patients had a higher event rate than controls (log-rank test p < .0001). Adjusted hazard ratio (HR) for the primary outcome was 2.04 (95% CI 1.52-2.73). Mortality did not differ between patients (n = 38; 4.7%) and controls (n = 35; 4.4%). A total of 82.5% patients and 91.3% controls were event-free during the follow up. Conclusions. In this long-term follow up of a contemporary, case-control study, the risk for cardiovascular events was higher in patients with a previous first MI compared with their matched controls, while mortality did not differ. The access to high quality of care and cardiac rehabilitation might partly explain the low rates of adverse outcomes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)

Keyword

Cardiovascular prevention
case-control study
long-term outcome
myocardial infarction
PAROKRANK
Cardiovascular prevention
case-control study
long-term outcome
myocardial infarction
PAROKRANK

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ref (subject category)
art (subject category)

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By the author/editor: Ferrannini, Giul ...; Almosawi, Mariam; Buhlin, Kare; De Faire, Ulf; Kjellström, Barb ...; Klinge, Björn; show more...; Nygren, Ake; Näsman, Per, Doc ...; Svenungsson, Eli ...; Ryden, Lars; Norhammar, Anna; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

Articles in the publication: Scandinavian Car ...

By the university: Royal Institute of Technology; Malmö University; Lund University; Karolinska Institutet

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