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Novel Benchmark Val...
Novel Benchmark Values for Redo Liver Transplantation Does the Outcome Justify the Effort?
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- Abbassi, Fariba (author)
- Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.
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- Gero, Daniel (author)
- Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.
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- Muller, Xavier (author)
- Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France.
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- Bueno, Alba (author)
- Kings Coll Hosp London, Inst Liver Studies, London, England.
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- Figiel, Wojciech (author)
- Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Warsaw, Poland.
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- Robin, Fabien (author)
- Univ Hosp Rennes, Dept HPB Surg & Transplantat, Rennes, France.
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- Laroche, Sophie (author)
- Hop Paul Brousse, Hepatobiliary Ctr, Dept Surg & Transplantat, Villejuif, France.
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- Picard, Benjamin (author)
- Hop Beaujon, APHP Nord, DMU PARABOL, Dept Anesthesiol Crit Care & Perioperat Med, Clichy, Nord, France.
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- Shankar, Sadhana (author)
- Leeds Teaching Hosp trust, Dept Abdominal Transplant & Hepatobiliary Surg, Leeds, W Yorkshire, England.
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- Ivanics, Tommy (author)
- Uppsala universitet,Gastrointestinalkirurgi,Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada.;Henry Ford Hosp, Dept Surg, Detroit, MI USA.
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- van Reeven, Marjolein (author)
- Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.
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- van Leeuwen, Otto B. (author)
- Univ Groningen, Univ Med Ctr Groningen, Div HPB Surg & Liver Transplantat, Groningen, Netherlands.
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- Braun, Hillary J. (author)
- Univ Calif San Francisco, Div Transplant Surg, San Francisco, CA USA.
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- Monbaliu, Diethard (author)
- Univ Hosp Leuven, Dept Abdominal Transplant Surg & Transplant Coord, Leuven, Belgium.
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- Breton, Antoine (author)
- Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France.
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- Vachharajani, Neeta (author)
- Washington Univ, St Louis Sch Med, Div Abdominal Transplantat, Dept Surg, St Louis, MO USA.
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- Bonaccorsi Riani, Eliano (author)
- Univ Hosp St Luc, Dept Abdominal & Transplant Surg, Brussels, Belgium.
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- Nowak, Greg (author)
- Karolinska Institutet
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- McMillan, Robert R. (author)
- Houston Methodist Hosp, Weill Cornell Med Ctr, Houston, TX USA.
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- Abu-Gazala, Samir (author)
- Hosp Univ Penn, Penn Transplant Inst, Dept Surg, Philadelphia, PA USA.
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- Nair, Amit (author)
- Univ Rochester, Div Transplantat & Hepatobiliary Surg, Rochester, MN USA.
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- Bruballa, Rocio (author)
- Hosp Italiano Buenos Aires, HPB & Liver Transplant Unit, Buenos Aires, Argentina.
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- Paterno, Flavio (author)
- Univ Hosp, Rutgers New Jersey Med Sch, Div Liver Transplant, Newark, NJ USA.
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- Weppler Sears, Deborah (author)
- Cleveland Clin Florida, Dept Abdominal & Transplant Surg, Weston, FL USA.
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- Pinna, Antonio D. (author)
- Cleveland Clin Florida, Dept Abdominal & Transplant Surg, Weston, FL USA.
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- Guarrera, James V. (author)
- Univ Hosp, Rutgers New Jersey Med Sch, Div Liver Transplant, Newark, NJ USA.
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- de Santibanes, Eduardo (author)
- Hosp Italiano Buenos Aires, HPB & Liver Transplant Unit, Buenos Aires, Argentina.
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- de Santibanes, Martin (author)
- Hosp Italiano Buenos Aires, HPB & Liver Transplant Unit, Buenos Aires, Argentina.
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- Hernandez-Alejandro, Roberto (author)
- Univ Rochester, Div Transplantat & Hepatobiliary Surg, Rochester, MN USA.
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- Olthoff, Kim (author)
- Hosp Univ Penn, Penn Transplant Inst, Dept Surg, Philadelphia, PA USA.
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- Ghobrial, R. Mark (author)
- Houston Methodist Hosp, Weill Cornell Med Ctr, Houston, TX USA.
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- Ericzon, Bo-Goran (author)
- Karolinska Institutet
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- Ciccarelli, Olga (author)
- Univ Hosp St Luc, Dept Abdominal & Transplant Surg, Brussels, Belgium.
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- Chapman, William C. (author)
- Washington Univ, St Louis Sch Med, Div Abdominal Transplantat, Dept Surg, St Louis, MO USA.
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- Mabrut, Jean-Yves (author)
- Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France.
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- Pirenne, Jacques (author)
- Univ Hosp Leuven, Dept Abdominal Transplant Surg & Transplant Coord, Leuven, Belgium.
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- Mullhaupt, Beat (author)
- Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.
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- Ascher, Nancy L. (author)
- Univ Calif San Francisco, Div Transplant Surg, San Francisco, CA USA.
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- Porte, Robert J. (author)
- Univ Groningen, Univ Med Ctr Groningen, Div HPB Surg & Liver Transplantat, Groningen, Netherlands.
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- de Meijer, Vincent E. (author)
- Univ Groningen, Univ Med Ctr Groningen, Div HPB Surg & Liver Transplantat, Groningen, Netherlands.
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- Polak, Wojciech G. (author)
- Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.
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- Sapisochin, Gonzalo (author)
- Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada.
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- Attia, Magdy (author)
- Leeds Teaching Hosp trust, Dept Abdominal Transplant & Hepatobiliary Surg, Leeds, W Yorkshire, England.
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- Soubrane, Olivier (author)
- Hop Beaujon, APHP Nord, DMU DIGEST, Dept HPB Surg & Liver Transplantat, Clichy, France.
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- Weiss, Emmanuel (author)
- Hop Beaujon, APHP Nord, DMU PARABOL, Dept Anesthesiol Crit Care & Perioperat Med, Clichy, Nord, France.
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- Adam, Rene A. (author)
- Hop Paul Brousse, Hepatobiliary Ctr, Dept Surg & Transplantat, Villejuif, France.
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- Cherqui, Daniel (author)
- Hop Paul Brousse, Hepatobiliary Ctr, Dept Surg & Transplantat, Villejuif, France.
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- Boudjema, Karim (author)
- Univ Hosp Rennes, Dept HPB Surg & Transplantat, Rennes, France.
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- Zieniewicz, Krzysztof (author)
- Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Warsaw, Poland.
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- Jassem, Wayel (author)
- Kings Coll Hosp London, Inst Liver Studies, London, England.
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- Dutkowski, Philipp (author)
- Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.
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- Clavien, Pierre-Alain (author)
- Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.
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Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France. (creator_code:org_t)
- Lippincott Williams & Wilkins, 2022
- 2022
- English.
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In: Annals of Surgery. - : Lippincott Williams & Wilkins. - 0003-4932 .- 1528-1140. ; 276:5, s. 860-867
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Objective: To define benchmark cutoffs for redo liver transplantation (redo-LT). Background: In the era of organ shortage, redo-LT is frequently discussed in terms of expected poor outcome and wasteful resources. However, there is a lack of benchmark data to reliably evaluate outcomes after redo-LT. Methods: We collected data on redo-LT between January 2010 and December 2018 from 22 high-volume transplant centers. Benchmark cases were defined as recipients with model of end stage liver disease (MELD) score <= 25, absence of portal vein thrombosis, no mechanical ventilation at the time of surgery, receiving a graft from a donor after brain death. Also, high-urgent priority and early redo-LT including those for primary nonfunction (PNF) or hepatic artery thrombosis were excluded. Benchmark cutoffs were derived from the 75th percentile of the medians of all benchmark centers. Results: Of 1110 redo-LT, 373 (34%) cases qualified as benchmark cases. Among these cases, the rate of postoperative complications until discharge was 76%, and increased up to 87% at 1-year, respectively. One-year overall survival rate was excellent with 90%. Benchmark cutoffs included Comprehensive Complication Index CCI (R) at 1-year of <= 72, and in-hospital and 1-year mortality rates of <= 13% and <= 15%, respectively. In contrast, patients who received a redo-LT for PNF showed worse outcomes with some values dramatically outside the redoLT benchmarks. Conclusion: This study shows that redo-LT achieves good outcome when looking at benchmark scenarios. However, this figure changes in high-risk redo-LT, as for example in PNF. This analysis objectifies for the first-time results and efforts for redo-LT and can serve as a basis for discussion about the use of scarce resources.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- benchmark
- retransplantation
- redo liver transplantation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Abbassi, Fariba
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Gero, Daniel
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Muller, Xavier
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Bueno, Alba
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Figiel, Wojciech
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Robin, Fabien
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show more...
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Laroche, Sophie
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Picard, Benjamin
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Shankar, Sadhana
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Ivanics, Tommy
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van Reeven, Marj ...
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van Leeuwen, Ott ...
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Braun, Hillary J ...
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Monbaliu, Dietha ...
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Breton, Antoine
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Vachharajani, Ne ...
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Bonaccorsi Riani ...
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Nowak, Greg
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McMillan, Robert ...
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Abu-Gazala, Sami ...
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Nair, Amit
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Bruballa, Rocio
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Paterno, Flavio
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Weppler Sears, D ...
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Pinna, Antonio D ...
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Guarrera, James ...
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de Santibanes, E ...
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de Santibanes, M ...
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Hernandez-Alejan ...
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Olthoff, Kim
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Ghobrial, R. Mar ...
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Ericzon, Bo-Gora ...
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Ciccarelli, Olga
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Chapman, William ...
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Mabrut, Jean-Yve ...
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Pirenne, Jacques
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Mullhaupt, Beat
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Ascher, Nancy L.
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Porte, Robert J.
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de Meijer, Vince ...
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Polak, Wojciech ...
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Sapisochin, Gonz ...
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Attia, Magdy
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Soubrane, Olivie ...
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Weiss, Emmanuel
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Adam, Rene A.
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Cherqui, Daniel
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Boudjema, Karim
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Zieniewicz, Krzy ...
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Jassem, Wayel
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Dutkowski, Phili ...
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Clavien, Pierre- ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Annals of Surger ...
- By the university
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Uppsala University
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Karolinska Institutet