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  • Kahn, Justine M.Columbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA. (author)

Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-05-12
  • AMER SOC HEMATOLOGY,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-413865
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413865URI
  • https://doi.org/10.1182/bloodadvances.2019000839DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143684647URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We examined the risk of subsequent neoplasms (SNs) and late mortality in children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases (NMDs). Weincluded 6028 patients (median age, 6 years; interquartile range, 1-11; range, <1 to 20) from the Center for International Blood and Marrow Transplant Research (1995-2012) registry. Standardized mortality ratios (SMRs) in 2-year survivors and standardized incidence ratios (SIRs) were calculated to compare mortality and SN rates with expected rates in the general population. Median follow-up of survivors was 7.8 years. Diagnoses included severe aplastic anemia (SAA; 24%), Fanconi anemia (FA; 10%), other marrow failure (6%), hemoglobinopathy (15%), immunodeficiency (23%), and metabolic/leukodystrophy syndrome (22%). Ten-year survival was 93% (95% confidence interval [95% CI], 92% to 94%; SMR, 4.2; 95% CI, 3.7-4.8). Seventy-one patients developed SNs (1.2%). Incidence was highest in FA (5.5%), SAA (1.1%), and other marrow failure syndromes (1.7%); for other NMDs, incidence was <1%. Hematologic (27%), oropharyngeal (25%), and skin cancers (13%) were most common. Leukemia risk was highest in the first 5 years posttransplantation; oropharyngeal, skin, liver, and thyroid tumors primarily occurred after 5 years. Despite a low number of SNs, patients had an 11-fold increased SN risk (SIR, 11; 95% CI, 8.9-13.9) compared with the general population. We report excellent long-term survival and low SN incidence in an international cohort of children undergoing HCT for NMDs. The risk of SN development was highest in patients with FA and marrow failure syndromes, highlighting the need for long-term posttransplantation surveillance in this population.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Brazauskas, RutaMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (author)
  • Tecca, Heather R.Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
  • Bo-Subait, StephanieMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
  • Buchbinder, DavidChildrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA. (author)
  • Battiwala, MinooSarah Cannon Bone & Marrow Transplant Program, Hematol Branch, Nashville, TN USA. (author)
  • Flowers, Mary E. D.Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA. (author)
  • Savani, Bipin N.Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA. (author)
  • Phelan, RachelMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Pediat, Div Pediat Hematol Oncol BMT, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA. (author)
  • Broglie, LarisaColumbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA. (author)
  • Abraham, Allistair A.Childrens Natl Med Ctr, Ctr Canc & Blood Disorders, Div Blood & Marrow Transplantat, Washington, DC 20010 USA. (author)
  • Keating, Amy K.Childrens Hosp Colorado, Aurora, CO USA.;Univ Colorado, Aurora, CO USA. (author)
  • Daly, AndrewTom Baker Canc Clin, Calgary, AB, Canada. (author)
  • Wirk, BaldeepSeattle Canc Alliance, Div Bone Marrow Transplant, Seattle, WA USA. (author)
  • George, BijuChristian Med Coll & Hosp, Dept Hematol, Vellore, Tamil Nadu, India. (author)
  • Alter, Blanche P.NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. (author)
  • Ustun, CelalettinRush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA. (author)
  • Freytes, Cesar O.Texas Transplant Inst, San Antonio, TX USA. (author)
  • Beitinjaneh, Amer M.Univ Miami Hlth Syst, Sylvester Comprehens Canc Ctr, Miami, FL USA. (author)
  • Duncan, ChristineBoston Childrens Hosp, Dept Pediat Oncol, Boston, MA USA.;Dana Farber Canc Inst, Boston, MA 02115 USA. (author)
  • Copelan, EdwardAtrium Hlth, Levine Canc Inst, Carolinas HealthCare Syst, Charlotte, NC USA. (author)
  • Hildebrandt, Gerhard C.Univ Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
  • Murthy, Hemant S.Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA. (author)
  • Lazarus, Hillard M.Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Med, Cleveland, OH 44106 USA.;Case Western Reserve Univ, Case Comprehens Canc Ctr, Seidman Canc Ctr, Cleveland, OH 44106 USA. (author)
  • Auletta, Jeffery J.Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Host Def Program, Columbus, OH USA. (author)
  • Myers, Kasiani C.Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA. (author)
  • Williams, Kirsten M.Childrens Natl Hlth Syst, Childrens Res Inst, Washington, DC USA. (author)
  • Page, Kristin M.Duke Univ, Med Ctr, Div Pediat Blood & Marrow Transplantat, Durham, NC USA. (author)
  • Vrooman, Lynda M.Boston Childrens Hosp, Dept Pediat Oncol, Boston, MA USA.;Dana Farber Canc Inst, Boston, MA 02115 USA. (author)
  • Norkin, MaximUniv Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA. (author)
  • Byrne, MichaelVanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA. (author)
  • Diaz, Miguel AngelHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain. (author)
  • Kamani, NayneshChildrens Natl Med Ctr, Ctr Canc & Blood Disorders, Washington, DC 20010 USA. (author)
  • Bhatt, Neel S.St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA. (author)
  • Rezvani, AndrewStanford Hlth Care, Stanford, CA USA. (author)
  • Farhadfar, NoshaUniv Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA. (author)
  • Mehta, Parinda A.Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA. (author)
  • Hematti, PeimanUniv Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA. (author)
  • Shaw, Peter J.Childrens Hosp Westmead, Westmead, NSW, Australia. (author)
  • Kamble, Rammurti T.Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA. (author)
  • Schears, RaquelMayo Clin, Div Hematol Bone Marrow Transplant, Rochester, MN USA. (author)
  • Olsson, RichardUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden(Swepub:uu)riols677 (author)
  • Hayashi, Robert J.Washington Univ, Sch Med, Dept Pediat, Div Pediat Hematol Oncol, St Louis, MO 63110 USA. (author)
  • Gale, Robert PeterImperial Coll London, Hematol Res Ctr, Dept Med, Div Expt Med, London, England. (author)
  • Mayo, Samantha J.Univ Toronto, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada. (author)
  • Chhabra, SaurabhMed Coll Wisconsin, Dept Pediat, Div Pediat Hematol Oncol BMT, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA. (author)
  • Rotz, Seth J.Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA. (author)
  • Badawy, Sherif M.Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA. (author)
  • Ganguly, SiddharthaUniv Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA. (author)
  • Pavletic, StevenNCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. (author)
  • Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA. (author)
  • Prestidge, TimStarship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand. (author)
  • Agrawal, VaibhavIndiana Univ, Simon Canc Ctr, Indianapolis, IN 46204 USA. (author)
  • Hogan, William J.Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.;Mayo Clin, Div Hematol Bone Marrow Transplant, Rochester, MN USA. (author)
  • Inamoto, YoshihiroNatl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan. (author)
  • Shaw, Bronwen E.Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
  • Satwani, PrakashColumbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA. (author)
  • Columbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA.Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)

Related titles

  • In:Blood Advances: AMER SOC HEMATOLOGY4:9, s. 2084-20942473-95292473-9537

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