Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases

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Fältnamn	Indikatorer	Metadata
000		11179naa a2201009 4500
001		oai:DiVA.org:uu-413865
003		SwePub
008		200621s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:143684647
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4138652 URI
024	7	a https://doi.org/10.1182/bloodadvances.20190008392 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1436846472 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kahn, Justine M.u Columbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA.4 aut
245	1 0	a Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases
264		c 2020-05-12
264	1	b AMER SOC HEMATOLOGY,c 2020
338		a print2 rdacarrier
520		a We examined the risk of subsequent neoplasms (SNs) and late mortality in children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases (NMDs). Weincluded 6028 patients (median age, 6 years; interquartile range, 1-11; range, <1 to 20) from the Center for International Blood and Marrow Transplant Research (1995-2012) registry. Standardized mortality ratios (SMRs) in 2-year survivors and standardized incidence ratios (SIRs) were calculated to compare mortality and SN rates with expected rates in the general population. Median follow-up of survivors was 7.8 years. Diagnoses included severe aplastic anemia (SAA; 24%), Fanconi anemia (FA; 10%), other marrow failure (6%), hemoglobinopathy (15%), immunodeficiency (23%), and metabolic/leukodystrophy syndrome (22%). Ten-year survival was 93% (95% confidence interval [95% CI], 92% to 94%; SMR, 4.2; 95% CI, 3.7-4.8). Seventy-one patients developed SNs (1.2%). Incidence was highest in FA (5.5%), SAA (1.1%), and other marrow failure syndromes (1.7%); for other NMDs, incidence was <1%. Hematologic (27%), oropharyngeal (25%), and skin cancers (13%) were most common. Leukemia risk was highest in the first 5 years posttransplantation; oropharyngeal, skin, liver, and thyroid tumors primarily occurred after 5 years. Despite a low number of SNs, patients had an 11-fold increased SN risk (SIR, 11; 95% CI, 8.9-13.9) compared with the general population. We report excellent long-term survival and low SN incidence in an international cohort of children undergoing HCT for NMDs. The risk of SN development was highest in patients with FA and marrow failure syndromes, highlighting the need for long-term posttransplantation surveillance in this population.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
700	1	a Brazauskas, Rutau Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 aut
700	1	a Tecca, Heather R.u Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.4 aut
700	1	a Bo-Subait, Stephanieu Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.4 aut
700	1	a Buchbinder, Davidu Childrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA.4 aut
700	1	a Battiwala, Minoou Sarah Cannon Bone & Marrow Transplant Program, Hematol Branch, Nashville, TN USA.4 aut
700	1	a Flowers, Mary E. D.u Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.4 aut
700	1	a Phelan, Rachelu Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Pediat, Div Pediat Hematol Oncol BMT, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.4 aut
700	1	a Broglie, Larisau Columbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA.4 aut
700	1	a Abraham, Allistair A.u Childrens Natl Med Ctr, Ctr Canc & Blood Disorders, Div Blood & Marrow Transplantat, Washington, DC 20010 USA.4 aut
700	1	a Keating, Amy K.u Childrens Hosp Colorado, Aurora, CO USA.;Univ Colorado, Aurora, CO USA.4 aut
700	1	a Daly, Andrewu Tom Baker Canc Clin, Calgary, AB, Canada.4 aut
700	1	a Wirk, Baldeepu Seattle Canc Alliance, Div Bone Marrow Transplant, Seattle, WA USA.4 aut
700	1	a George, Bijuu Christian Med Coll & Hosp, Dept Hematol, Vellore, Tamil Nadu, India.4 aut
700	1	a Alter, Blanche P.u NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.4 aut
700	1	a Ustun, Celalettinu Rush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA.4 aut
700	1	a Freytes, Cesar O.u Texas Transplant Inst, San Antonio, TX USA.4 aut
700	1	a Beitinjaneh, Amer M.u Univ Miami Hlth Syst, Sylvester Comprehens Canc Ctr, Miami, FL USA.4 aut
700	1	a Duncan, Christineu Boston Childrens Hosp, Dept Pediat Oncol, Boston, MA USA.;Dana Farber Canc Inst, Boston, MA 02115 USA.4 aut
700	1	a Copelan, Edwardu Atrium Hlth, Levine Canc Inst, Carolinas HealthCare Syst, Charlotte, NC USA.4 aut
700	1	a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut
700	1	a Murthy, Hemant S.u Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.4 aut
700	1	a Lazarus, Hillard M.u Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Med, Cleveland, OH 44106 USA.;Case Western Reserve Univ, Case Comprehens Canc Ctr, Seidman Canc Ctr, Cleveland, OH 44106 USA.4 aut
700	1	a Auletta, Jeffery J.u Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Host Def Program, Columbus, OH USA.4 aut
700	1	a Myers, Kasiani C.u Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA.4 aut
700	1	a Williams, Kirsten M.u Childrens Natl Hlth Syst, Childrens Res Inst, Washington, DC USA.4 aut
700	1	a Page, Kristin M.u Duke Univ, Med Ctr, Div Pediat Blood & Marrow Transplantat, Durham, NC USA.4 aut
700	1	a Vrooman, Lynda M.u Boston Childrens Hosp, Dept Pediat Oncol, Boston, MA USA.;Dana Farber Canc Inst, Boston, MA 02115 USA.4 aut
700	1	a Norkin, Maximu Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.4 aut
700	1	a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.4 aut
700	1	a Diaz, Miguel Angelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.4 aut
700	1	a Kamani, Nayneshu Childrens Natl Med Ctr, Ctr Canc & Blood Disorders, Washington, DC 20010 USA.4 aut
700	1	a Bhatt, Neel S.u St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA.4 aut
700	1	a Rezvani, Andrewu Stanford Hlth Care, Stanford, CA USA.4 aut
700	1	a Farhadfar, Noshau Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.4 aut
700	1	a Mehta, Parinda A.u Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA.4 aut
700	1	a Hematti, Peimanu Univ Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA.4 aut
700	1	a Shaw, Peter J.u Childrens Hosp Westmead, Westmead, NSW, Australia.4 aut
700	1	a Kamble, Rammurti T.u Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.4 aut
700	1	a Schears, Raquelu Mayo Clin, Div Hematol Bone Marrow Transplant, Rochester, MN USA.4 aut
700	1	a Olsson, Richardu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden4 aut0 (Swepub:uu)riols677
700	1	a Hayashi, Robert J.u Washington Univ, Sch Med, Dept Pediat, Div Pediat Hematol Oncol, St Louis, MO 63110 USA.4 aut
700	1	a Gale, Robert Peteru Imperial Coll London, Hematol Res Ctr, Dept Med, Div Expt Med, London, England.4 aut
700	1	a Mayo, Samantha J.u Univ Toronto, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada.4 aut
700	1	a Chhabra, Saurabhu Med Coll Wisconsin, Dept Pediat, Div Pediat Hematol Oncol BMT, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.4 aut
700	1	a Rotz, Seth J.u Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA.4 aut
700	1	a Badawy, Sherif M.u Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.4 aut
700	1	a Ganguly, Siddharthau Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.4 aut
700	1	a Pavletic, Stevenu NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut
700	1	a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.4 aut
700	1	a Prestidge, Timu Starship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.4 aut
700	1	a Agrawal, Vaibhavu Indiana Univ, Simon Canc Ctr, Indianapolis, IN 46204 USA.4 aut
700	1	a Hogan, William J.u Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.;Mayo Clin, Div Hematol Bone Marrow Transplant, Rochester, MN USA.4 aut
700	1	a Inamoto, Yoshihirou Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.4 aut
700	1	a Shaw, Bronwen E.u Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.4 aut
700	1	a Satwani, Prakashu Columbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA.4 aut
710	2	a Columbia Univ, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA.b Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 org
773	0	t Blood Advancesd : AMER SOC HEMATOLOGYg 4:9, s. 2084-2094q 4:9<2084-2094x 2473-9529x 2473-9537
856	4	u https://ashpublications.org/bloodadvances/article-pdf/4/9/2084/1728713/advancesadv2019000839.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413865
856	4 8	u https://doi.org/10.1182/bloodadvances.2019000839
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:143684647

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Av författaren/redakt...: Kahn, Justine M.; Brazauskas, Ruta; Tecca, Heather R ...; Bo-Subait, Steph ...; Buchbinder, Davi ...; Battiwala, Minoo; visa fler...; Flowers, Mary E. ...; Savani, Bipin N.; Phelan, Rachel; Broglie, Larisa; Abraham, Allista ...; Keating, Amy K.; Daly, Andrew; Wirk, Baldeep; George, Biju; Alter, Blanche P ...; Ustun, Celaletti ...; Freytes, Cesar O ...; Beitinjaneh, Ame ...; Duncan, Christin ...; Copelan, Edward; Hildebrandt, Ger ...; Murthy, Hemant S ...; Lazarus, Hillard ...; Auletta, Jeffery ...; Myers, Kasiani C ...; Williams, Kirste ...; Page, Kristin M.; Vrooman, Lynda M ...; Norkin, Maxim; Byrne, Michael; Diaz, Miguel Ang ...; Kamani, Naynesh; Bhatt, Neel S.; Rezvani, Andrew; Farhadfar, Nosha; Mehta, Parinda A ...; Hematti, Peiman; Shaw, Peter J.; Kamble, Rammurti ...; Schears, Raquel; Olsson, Richard; Hayashi, Robert ...; Gale, Robert Pet ...; Mayo, Samantha J ...; Chhabra, Saurabh; Rotz, Seth J.; Badawy, Sherif M ...; Ganguly, Siddhar ...; Pavletic, Steven; Nishihori, Taiga; Prestidge, Tim; Agrawal, Vaibhav; Hogan, William J ...; Inamoto, Yoshihi ...; Shaw, Bronwen E.; Satwani, Prakash; visa färre...

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