Coagulopathy and haemorrhagic progression in traumatic brain injury : advances in mechanisms, diagnosis, and management

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Maegele, MarcDepartment for Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center, University Witten/Herdecke, Cologne, Germany; Institute for Research in Operative Medicine, University Witten/Herdecke, Cologne, Germany (författare)

Coagulopathy and haemorrhagic progression in traumatic brain injury : advances in mechanisms, diagnosis, and management

Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

Lancet Publishing Group,2017
18 s.

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:a25d6fee-eded-45ec-a8c3-b914a3f954bc
https://lup.lub.lu.se/record/a25d6fee-eded-45ec-a8c3-b914a3f954bcURI
https://doi.org/10.1016/S1474-4422(17)30197-7DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113246URI

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Språk:engelska
Sammanfattning på:engelska

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Normal haemostasis depends on an intricate balance between mechanisms of bleeding and mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI). Impaired haemostasis could exacerbate the primary insult with risk of initiation or aggravation of bleeding; anticoagulant use at the time of injury can also contribute to bleeding risk after TBI. Many patients with TBI have abnormalities on conventional coagulation tests at admission to the emergency department, and the presence of coagulopathy is associated with increased morbidity and mortality. Further blood testing often reveals a range of changes affecting platelet numbers and function, procoagulant or anticoagulant factors, fibrinolysis, and interactions between the coagulation system and the vascular endothelium, brain tissue, inflammatory mechanisms, and blood flow dynamics. However, the degree to which these coagulation abnormalities affect TBI outcomes and whether they are modifiable risk factors are not known. Although the main challenge for management is to address the risk of hypocoagulopathy with prolonged bleeding and progression of haemorrhagic lesions, the risk of hypercoagulopathy with an increased prothrombotic tendency also warrants consideration.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng

Biuppslag (personer, institutioner, konferenser, titlar ...)

Schöchl, HerbertParacelsus Private Medical University of Salzburg,Department for Anaesthesiology and Intensive Care Medicine, AUVA Trauma Academic Teaching Hospital, Paracelsus Medical University Salzburg, Salzburg, Austria (författare)
Menovsky, TomasDepartment for Neurosurgery, Antwerp University Hospital, University of Antwerp, Edegem, Belgium (författare)
Maréchal, HuguesCentre hospitalier régional de la Citadelle,Department of Anaesthesiology and Intensive Care Medicine, CRH La Citadelle, Liège, Belgium (författare)
Marklund, NiklasLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Department of Clinical Sciences, Division of Neurosurgery, University Hospital of Southern Sweden, Lund University, Lund, Sweden(Swepub:lu)ni0588ma (författare)
Büki, Andras,1966-Department of Neurosurgery, The MTA-PTE Clinical Neuroscience MR Research Group, Janos Szentagothai Research Center, Hungarian Brain Research Program, University of Pécs, Pécs, Hungary(Swepub:oru)asbi (författare)
Stanworth, SimonNHS Blood and Transplant/Oxford University Hospitals NHS Foundation Trust, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (författare)
Department for Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center, University Witten/Herdecke, Cologne, Germany; Institute for Research in Operative Medicine, University Witten/Herdecke, Cologne, GermanyParacelsus Private Medical University of Salzburg (creator_code:org_t)

Sammanhörande titlar

Ingår i:The Lancet Neurology: Lancet Publishing Group16:8, s. 630-6471474-44221474-4465

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Av författaren/redakt...: Maegele, Marc; Schöchl, Herbert; Menovsky, Tomas; Maréchal, Hugues; Marklund, Niklas; Büki, Andras, 19 ...; visa fler...; Stanworth, Simon; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

Artiklar i publikationen: The Lancet Neuro ...

Av lärosätet: Lunds universitet; Örebro universitet

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