WFRF:(Schöchl Herbert)
Sökning: WFRF:(Schöchl Herbert) > Coagulopathy and ha...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04847naa a2200421 4500 | |
| 001 | oai:lup.lub.lu.se:a25d6fee-eded-45ec-a8c3-b914a3f954bc | |
| 003 | SwePub | |
| 008 | 170801s2017 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:oru-113246 | |
| 024 | 7 | a https://lup.lub.lu.se/record/a25d6fee-eded-45ec-a8c3-b914a3f954bc2 URI |
| 024 | 7 | a https://doi.org/10.1016/S1474-4422(17)30197-72 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1132462 URI |
| 040 | a (SwePub)lud (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a for2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Maegele, Marcu Department for Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center, University Witten/Herdecke, Cologne, Germany; Institute for Research in Operative Medicine, University Witten/Herdecke, Cologne, Germany4 aut |
| 245 | 1 0 | a Coagulopathy and haemorrhagic progression in traumatic brain injury : advances in mechanisms, diagnosis, and management |
| 264 | 1 | b Lancet Publishing Group,c 2017 |
| 300 | a 18 s. | |
| 520 | a Normal haemostasis depends on an intricate balance between mechanisms of bleeding and mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI). Impaired haemostasis could exacerbate the primary insult with risk of initiation or aggravation of bleeding; anticoagulant use at the time of injury can also contribute to bleeding risk after TBI. Many patients with TBI have abnormalities on conventional coagulation tests at admission to the emergency department, and the presence of coagulopathy is associated with increased morbidity and mortality. Further blood testing often reveals a range of changes affecting platelet numbers and function, procoagulant or anticoagulant factors, fibrinolysis, and interactions between the coagulation system and the vascular endothelium, brain tissue, inflammatory mechanisms, and blood flow dynamics. However, the degree to which these coagulation abnormalities affect TBI outcomes and whether they are modifiable risk factors are not known. Although the main challenge for management is to address the risk of hypocoagulopathy with prolonged bleeding and progression of haemorrhagic lesions, the risk of hypercoagulopathy with an increased prothrombotic tendency also warrants consideration. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 700 | 1 | a Schöchl, Herbertu Paracelsus Private Medical University of Salzburg,Department for Anaesthesiology and Intensive Care Medicine, AUVA Trauma Academic Teaching Hospital, Paracelsus Medical University Salzburg, Salzburg, Austria4 aut |
| 700 | 1 | a Menovsky, Tomasu Department for Neurosurgery, Antwerp University Hospital, University of Antwerp, Edegem, Belgium4 aut |
| 700 | 1 | a Maréchal, Huguesu Centre hospitalier régional de la Citadelle,Department of Anaesthesiology and Intensive Care Medicine, CRH La Citadelle, Liège, Belgium4 aut |
| 700 | 1 | a Marklund, Niklasu Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Department of Clinical Sciences, Division of Neurosurgery, University Hospital of Southern Sweden, Lund University, Lund, Sweden4 aut0 (Swepub:lu)ni0588ma |
| 700 | 1 | a Büki, Andras,d 1966-u Department of Neurosurgery, The MTA-PTE Clinical Neuroscience MR Research Group, Janos Szentagothai Research Center, Hungarian Brain Research Program, University of Pécs, Pécs, Hungary4 aut0 (Swepub:oru)asbi |
| 700 | 1 | a Stanworth, Simonu NHS Blood and Transplant/Oxford University Hospitals NHS Foundation Trust, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom4 aut |
| 710 | 2 | a Department for Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center, University Witten/Herdecke, Cologne, Germany; Institute for Research in Operative Medicine, University Witten/Herdecke, Cologne, Germanyb Paracelsus Private Medical University of Salzburg4 org |
| 773 | 0 | t The Lancet Neurologyd : Lancet Publishing Groupg 16:8, s. 630-647q 16:8<630-647x 1474-4422x 1474-4465 |
| 856 | 4 | u http://dx.doi.org/10.1016/S1474-4422(17)30197-7y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/a25d6fee-eded-45ec-a8c3-b914a3f954bc |
| 856 | 4 8 | u https://doi.org/10.1016/S1474-4422(17)30197-7 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113246 |
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