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C-Myc protein expre...
C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer
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- Lang, Christian (författare)
- Medical University of Vienna
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- Megyesfalvi, Zsolt (författare)
- Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Lantos, Andras (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Oberndorfer, Felicitas (författare)
- Medical University of Vienna
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- Hoda, Mir Alireza (författare)
- Medical University of Vienna
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- Solta, Anna (författare)
- Medical University of Vienna
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- Ferencz, Bence (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Fillinger, Janos (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Solyom-Tisza, Anna (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Querner, Alessandro Saeed (författare)
- Medical University of Vienna
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- Egger, Felix (författare)
- Medical University of Vienna
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- Boettiger, Kristiina (författare)
- Medical University of Vienna
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- Klikovits, Thomas (författare)
- Clinic Floridsdorf
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- Timelthaler, Gerald (författare)
- Medical University of Vienna
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- Renyi-Vamos, Ferenc (författare)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Aigner, Clemens (författare)
- Medical University of Vienna
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- Hoetzenecker, Konrad (författare)
- Medical University of Vienna
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- Laszlo, Viktoria (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest,Medical University of Vienna
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- Schelch, Karin (författare)
- Medical University of Vienna
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- Dome, Balazs (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University,Medical University of Vienna
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: World Journal of Surgical Oncology. - 1477-7819. ; 22:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: By being highly involved in the tumor evolution and disease progression of small cell lung cancer (SCLC), Myc family members (C-Myc, L-Myc, and N-Myc) might represent promising targetable molecules. Our aim was to investigate the expression pattern and prognostic relevance of these oncogenic proteins in an international cohort of surgically resected SCLC tumors. Methods: Clinicopathological data and surgically resected tissue specimens from 104 SCLC patients were collected from two collaborating European institutes. Tissue sections were stained by immunohistochemistry (IHC) for all three Myc family members and the recently introduced SCLC molecular subtype-markers (ASCL1, NEUROD1, POU2F3, and YAP1). Results: IHC analysis showed C-Myc, L-Myc, and N-Myc positivity in 48%, 63%, and 9% of the specimens, respectively. N-Myc positivity significantly correlated with the POU2F3-defined molecular subtype (r = 0.6913, p = 0.0056). SCLC patients with C-Myc positive tumors exhibited significantly worse overall survival (OS) (20 vs. 44 months compared to those with C-Myc negative tumors, p = 0.0176). Ultimately, in a multivariate risk model adjusted for clinicopathological and treatment confounders, positive C-Myc expression was confirmed as an independent prognosticator of impaired OS (HR 1.811, CI 95% 1.054–3.113, p = 0.032). Conclusions: Our study provides insights into the clinical aspects of Myc family members in surgically resected SCLC tumors. Notably, besides showing that positivity of Myc family members varies across the patients, we also reveal that C-Myc protein expression independently correlates with worse survival outcomes. Further studies are warranted to investigate the role of Myc family members as potential prognostic and predictive markers in this hard-to-treat disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Immunohistochemistry
- Molecular subtypes
- Myc family
- Small cell lung cancer
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Lang, Christian
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Megyesfalvi, Zso ...
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Lantos, Andras
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Oberndorfer, Fel ...
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Hoda, Mir Alirez ...
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Solta, Anna
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visa fler...
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Ferencz, Bence
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Fillinger, Janos
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Solyom-Tisza, An ...
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Querner, Alessan ...
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Egger, Felix
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Boettiger, Krist ...
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Klikovits, Thoma ...
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Timelthaler, Ger ...
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Renyi-Vamos, Fer ...
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Aigner, Clemens
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Hoetzenecker, Ko ...
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Laszlo, Viktoria
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Schelch, Karin
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Dome, Balazs
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