WFRF:(Scherer Steven E.)
Sökning: WFRF:(Scherer Steven E.) > (2020-2022) > Common Genetic Vari...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 10275naa a2202425 4500 | |
| 001 | oai:gup.ub.gu.se/338417 | |
| 003 | SwePub | |
| 008 | 240608s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:236324647 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3384172 URI |
| 024 | 7 | a https://doi.org/10.1016/j.bpsgos.2021.09.0012 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2363246472 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Watson, Hunna J.4 aut |
| 245 | 1 0 | a Common Genetic Variation and Age of Onset of Anorexia Nervosa |
| 264 | 1 | b Elsevier BV,c 2022 |
| 520 | a BACKGROUND: Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche.METHODS: A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (,13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses.RESULTS: Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism-h2) were 0.01-0.04 for age of onset, 0.16-0.25 for early-onset AN, and 0.17-0.25 for typical-onset AN. Early-and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age of onset and early-onset AN estimated from independent GWASs significantly predicted age of onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early -onset AN.CONCLUSIONS: Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 700 | 1 | a Thornton, Laura M.4 aut |
| 700 | 1 | a Yilmaz, Zeynep4 aut |
| 700 | 1 | a Baker, Jessica H.4 aut |
| 700 | 1 | a Coleman, Jonathan R. I.4 aut |
| 700 | 1 | a Adan, Roger A. H.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xadaro |
| 700 | 1 | a Alfredsson, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Andreassen, Ole A.4 aut |
| 700 | 1 | a Ask, Helga4 aut |
| 700 | 1 | a Berrettini, Wade H.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Boehm, Ilka4 aut |
| 700 | 1 | a Boni, Claudette4 aut |
| 700 | 1 | a Buehren, Katharina4 aut |
| 700 | 1 | a Bulant, Josef4 aut |
| 700 | 1 | a Burghardt, Roland4 aut |
| 700 | 1 | a Chang, Xiao4 aut |
| 700 | 1 | a Cichon, Sven4 aut |
| 700 | 1 | a Cone, Roger D.4 aut |
| 700 | 1 | a Courtet, Philippe4 aut |
| 700 | 1 | a Crow, Scott4 aut |
| 700 | 1 | a Crowley, James J.4 aut |
| 700 | 1 | a Danner, Unna N.4 aut |
| 700 | 1 | a de Zwaan, Martina4 aut |
| 700 | 1 | a Dedoussis, George4 aut |
| 700 | 1 | a DeSocio, Janiece E.4 aut |
| 700 | 1 | a Dick, Danielle M.4 aut |
| 700 | 1 | a Dikeos, Dimitris4 aut |
| 700 | 1 | a Dina, Christian4 aut |
| 700 | 1 | a Djurovic, Srdjan4 aut |
| 700 | 1 | a Dmitrzak-Weglarz, Monika4 aut |
| 700 | 1 | a Docampo-Martinez, Elisa4 aut |
| 700 | 1 | a Duriez, Philibert4 aut |
| 700 | 1 | a Egberts, Karin4 aut |
| 700 | 1 | a Ehrlich, Stefan4 aut |
| 700 | 1 | a Eriksson, Johan G.4 aut |
| 700 | 1 | a Escaramis, Georgia4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Estivill, Xavier4 aut |
| 700 | 1 | a Farmer, Anne4 aut |
| 700 | 1 | a Fernandez-Aranda, Fernando4 aut |
| 700 | 1 | a Fichter, Manfred M.4 aut |
| 700 | 1 | a Foecker, Manuel4 aut |
| 700 | 1 | a Foretova, Lenka4 aut |
| 700 | 1 | a Forstner, Andreas J.4 aut |
| 700 | 1 | a Frei, Oleksandr4 aut |
| 700 | 1 | a Gallinger, Steven4 aut |
| 700 | 1 | a Giegling, Ina4 aut |
| 700 | 1 | a Giuranna, Johanna4 aut |
| 700 | 1 | a Gonidakis, Fragiskos4 aut |
| 700 | 1 | a Gorwood, Philip4 aut |
| 700 | 1 | a Gratacos, Monica4 aut |
| 700 | 1 | a Guillaume, Sebastien4 aut |
| 700 | 1 | a Guo, Yiran4 aut |
| 700 | 1 | a Hakonarson, Hakon4 aut |
| 700 | 1 | a Hauser, Joanna4 aut |
| 700 | 1 | a Havdahl, Alexandra4 aut |
| 700 | 1 | a Hebebrand, Johannes4 aut |
| 700 | 1 | a Helder, Sietske G.4 aut |
| 700 | 1 | a Herms, Stefan4 aut |
| 700 | 1 | a Herpertz-Dahlmann, Beate4 aut |
| 700 | 1 | a Herzog, Wolfgang4 aut |
| 700 | 1 | a Hinney, Anke4 aut |
| 700 | 1 | a Huebel, Christopher4 aut |
| 700 | 1 | a Hudson, James I.4 aut |
| 700 | 1 | a Imgart, Hartmut4 aut |
| 700 | 1 | a Jamain, Stephanie4 aut |
| 700 | 1 | a Janout, Vladimir4 aut |
| 700 | 1 | a Jimenez-Murcia, Susana4 aut |
| 700 | 1 | a Jones, Ian R.4 aut |
| 700 | 1 | a Julia, Antonio4 aut |
| 700 | 1 | a Kalsi, Gursharan4 aut |
| 700 | 1 | a Kaminska, Deborah4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Karhunen, Leila4 aut |
| 700 | 1 | a Kas, Martien J. H.4 aut |
| 700 | 1 | a Keel, Pamela K.4 aut |
| 700 | 1 | a Kennedy, James L.4 aut |
| 700 | 1 | a Keski-Rahkonen, Anna4 aut |
| 700 | 1 | a Kiezebrink, Kirsty4 aut |
| 700 | 1 | a Klareskog, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Klump, Kelly L.4 aut |
| 700 | 1 | a Knudsen, Gun Peggy S.4 aut |
| 700 | 1 | a La Via, Maria C.4 aut |
| 700 | 1 | a Le Hellard, Stephanie4 aut |
| 700 | 1 | a Leboyer, Marion4 aut |
| 700 | 1 | a Li, Dong4 aut |
| 700 | 1 | a Lilenfeld, Lisau Karolinska Institutet4 aut |
| 700 | 1 | a Lin, Bochao4 aut |
| 700 | 1 | a Lissowska, Jolanta4 aut |
| 700 | 1 | a Luykx, Jurjen4 aut |
| 700 | 1 | a Magistretti, Pierre4 aut |
| 700 | 1 | a Maj, Mariou Karolinska Institutet4 aut |
| 700 | 1 | a Marsal, Sara4 aut |
| 700 | 1 | a Marshall, Christian R.4 aut |
| 700 | 1 | a Mattingsdal, Morten4 aut |
| 700 | 1 | a Meulenbelt, Ingrid4 aut |
| 700 | 1 | a Micali, Nadia4 aut |
| 700 | 1 | a Mitchell, Karen S.4 aut |
| 700 | 1 | a Monteleone, Alessio Maria4 aut |
| 700 | 1 | a Monteleone, Palmiero4 aut |
| 700 | 1 | a Myers, Richard4 aut |
| 700 | 1 | a Navratilova, Marie4 aut |
| 700 | 1 | a Ntalla, Ionna4 aut |
| 700 | 1 | a O'Toole, Julie K.4 aut |
| 700 | 1 | a Ophoff, Roel A.4 aut |
| 700 | 1 | a Padyukov, Leonid4 aut |
| 700 | 1 | a Pantel, Jacques4 aut |
| 700 | 1 | a Papezova, Hana4 aut |
| 700 | 1 | a Pinto, Dalila4 aut |
| 700 | 1 | a Raevuori, Anu4 aut |
| 700 | 1 | a Ramoz, Nicolas4 aut |
| 700 | 1 | a Reichborn-Kjennerud, Ted4 aut |
| 700 | 1 | a Ricca, Valdo4 aut |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Ripke, Stephan4 aut |
| 700 | 1 | a Ritschel, Franziska4 aut |
| 700 | 1 | a Roberts, Marion4 aut |
| 700 | 1 | a Rotondo, Alessandro4 aut |
| 700 | 1 | a Rujescu, Dan4 aut |
| 700 | 1 | a Rybakowski, Filip4 aut |
| 700 | 1 | a Scherag, Andre4 aut |
| 700 | 1 | a Scherer, Stephen W.4 aut |
| 700 | 1 | a Schmidt, Ulrike4 aut |
| 700 | 1 | a Scott, Laura J.4 aut |
| 700 | 1 | a Seitz, Jochen4 aut |
| 700 | 1 | a Silen, Yasmina4 aut |
| 700 | 1 | a Slachtova, Lenka4 aut |
| 700 | 1 | a Slagboom, P. Eline4 aut |
| 700 | 1 | a Slof-Op 't Landt, Margarita C. T.4 aut |
| 700 | 1 | a Slopien, Agnieszka4 aut |
| 700 | 1 | a Sorbi, Sandro4 aut |
| 700 | 1 | a Swiatkowska, Beata4 aut |
| 700 | 1 | a Tortorella, Alfonso4 aut |
| 700 | 1 | a Tozzi, Federica4 aut |
| 700 | 1 | a Treasure, Janet4 aut |
| 700 | 1 | a Tsitsika, Artemis4 aut |
| 700 | 1 | a Tyszkiewicz-Nwafor, Marta4 aut |
| 700 | 1 | a Tziouvas, Konstantinos4 aut |
| 700 | 1 | a van Elburg, Annemarie A.4 aut |
| 700 | 1 | a van Furth, Eric F.4 aut |
| 700 | 1 | a Walton, Esther4 aut |
| 700 | 1 | a Widen, Elisabeth4 aut |
| 700 | 1 | a Zerwas, Stephanie4 aut |
| 700 | 1 | a Zipfel, Stephan4 aut |
| 700 | 1 | a Bergen, Andrew W.4 aut |
| 700 | 1 | a Boden, Joseph M.4 aut |
| 700 | 1 | a Brandt, Harry4 aut |
| 700 | 1 | a Crawford, Steven4 aut |
| 700 | 1 | a Halmi, Katherine A.4 aut |
| 700 | 1 | a Horwood, L. John4 aut |
| 700 | 1 | a Johnson, Craig4 aut |
| 700 | 1 | a Kaplan, Allan S.4 aut |
| 700 | 1 | a Kaye, Walter H.4 aut |
| 700 | 1 | a Mitchell, James E.4 aut |
| 700 | 1 | a Olsen, Catherine M.4 aut |
| 700 | 1 | a Pearson, John F.4 aut |
| 700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
| 700 | 1 | a Strober, Michael4 aut |
| 700 | 1 | a Werge, Thomas4 aut |
| 700 | 1 | a Whiteman, David C.4 aut |
| 700 | 1 | a Woodside, D. Blake4 aut |
| 700 | 1 | a Gordon, Scott4 aut |
| 700 | 1 | a Maguire, Sarah4 aut |
| 700 | 1 | a Larsen, Janne T.4 aut |
| 700 | 1 | a Parker, Richard4 aut |
| 700 | 1 | a Petersen, Liselotte4 aut |
| 700 | 1 | a Jordan, Jennifer4 aut |
| 700 | 1 | a Kennedy, Martin4 aut |
| 700 | 1 | a Wade, Tracey D.4 aut |
| 700 | 1 | a Birgegard, Andreasu Karolinska Institutet4 aut |
| 700 | 1 | a Lichtenstein, Paul4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a Mortensen, Preben Bo4 aut |
| 700 | 1 | a Breen, Gerome4 aut |
| 700 | 1 | a Bulik, Cynthia M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCEd : Elsevier BVg 2:4, s. 368-378q 2:4<368-378x 2667-1743 |
| 856 | 4 | u https://doi.org/10.1016/j.bpsgos.2021.09.001 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/338417 |
| 856 | 4 8 | u https://doi.org/10.1016/j.bpsgos.2021.09.001 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:236324647 |
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