Sökning: WFRF:(Schexnaydre Erin) > Clinically observed...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05227naa a2200637 4500 | |
001 | oai:DiVA.org:umu-194639 | |
003 | SwePub | |
008 | 220513s2022 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:6077de65-fb43-4101-8278-cc74aba4f0d3 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1946392 URI |
024 | 7 | a https://doi.org/10.1002/1873-3468.143542 DOI |
024 | 7 | a https://lup.lub.lu.se/record/6077de65-fb43-4101-8278-cc74aba4f0d32 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kumar, Pravinu Umeå University,Umeå universitet,Institutionen för medicinsk kemi och biofysik,Molekylär Infektionsmedicin, Sverige (MIMS),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)4 aut0 (Swepub:umu)prku0012 |
245 | 1 0 | a Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation |
264 | c 2022-04-25 | |
264 | 1 | b John Wiley & Sons,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a Nonstructural protein 1 (Nsp1) of SARS-CoV-2 inhibits host cell translation through an interaction between its C-terminal domain and the 40S ribosome. The N-terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associated with altered COVID-19 disease progression. Here, we characterize the efficiency of translational inhibition by clinically observed Nsp1 deletion variants. We show that a frequent deletion of residues 79–89 severely reduces the ability of Nsp1 to inhibit translation while not abrogating Nsp1 binding to the 40S. Notably, while the SARS-CoV-2 5′ untranslated region enhances translation of mRNA, it does not protect from Nsp1-mediated inhibition. Finally, thermal stability measurements and structure predictions reveal a correlation between stability of the NTD and the efficiency of translation inhibition. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
653 | a COVID-19 | |
653 | a Nsp1 | |
653 | a pathogenicity | |
653 | a ribosome | |
653 | a SARS-CoV-2 | |
653 | a virus | |
653 | a Nsp1 | |
653 | a SARS-CoV-2 | |
653 | a COVID-19 | |
653 | a pathogenicity | |
653 | a ribosome | |
653 | a translation | |
653 | a virus | |
700 | 1 | a Schexnaydre, Erinu Umeå University,Umeå universitet,Institutionen för medicinsk kemi och biofysik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Molekylär Infektionsmedicin, Sverige (MIMS)4 aut0 (Swepub:umu)ersc0013 |
700 | 1 | a Rafie, Karimu Umeå University,Umeå universitet,Institutionen för medicinsk kemi och biofysik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Molekylär Infektionsmedicin, Sverige (MIMS)4 aut0 (Swepub:umu)kara0064 |
700 | 1 | a Kurata, Tatsuakiu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)ta0660ku |
700 | 1 | a Terenin, Ilyau Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Russian Federation4 aut |
700 | 1 | a Hauryliuk, Vasili,d 1980-u Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Experimental Medicine, University of Lund, Sweden; Institute of Technology, University of Tartu, Estonia,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)va5618ha |
700 | 1 | a Carlson, Lars-Andersu Umeå University,Umeå universitet,Institutionen för medicinsk kemi och biofysik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Molekylär Infektionsmedicin, Sverige (MIMS)4 aut0 (Swepub:umu)laca0012 |
710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
773 | 0 | t FEBS Lettersd : John Wiley & Sonsg 596:9, s. 1203-1213q 596:9<1203-1213x 0014-5793x 1873-3468 |
856 | 4 | u https://doi.org/10.1002/1873-3468.14354y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1658132/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1002/1873-3468.14354x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194639 |
856 | 4 8 | u https://doi.org/10.1002/1873-3468.14354 |
856 | 4 8 | u https://lup.lub.lu.se/record/6077de65-fb43-4101-8278-cc74aba4f0d3 |
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