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Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy
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- Garibotto, Valentina (författare)
- Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland; Univ Geneva, Fac Med, Geneva, Switzerland
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- Wissmeyer, Michael (författare)
- Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
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- Giavri, Zoi (författare)
- Advantis Med Imaging, Eindhoven, Netherlands
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- Goldstein, Rachel (författare)
- Univ Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland
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- Seimbille, Yann (författare)
- Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
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- Seeck, Margitta (författare)
- Univ Geneva, Fac Med, Geneva, Switzerland; Univ Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland
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- Ratib, Osman (författare)
- Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
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- Haller, Sven (författare)
- Uppsala universitet,Radiologi,Univ Geneva, Fac Med, Geneva, Switzerland; CIRD, Geneva, Switzerland
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- Picard, Fabienne (författare)
- Univ Geneva, Fac Med, Geneva, Switzerland; Univ Hosp Geneva, EEG & Epilepsy Unit, Dept Neurol, Geneva, Switzerland
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(creator_code:org_t)
- 2018-09-29
- 2019
- Engelska.
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 46:2, s. 385-395
- Relaterad länk:
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https://archive-ouve...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [18F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.Methods: We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. All patients underwent PET/CT using F-A-85380 and [18F]-fluorodeoxyglucose (FDG), 3D T1 MRI and diffusion tensor imaging (DTI). F-A-85380 and FDG images were compared with the control group using a voxel-wise (SPM12) and a volumes of interest (VOI) analysis.Results: In the group of patients with IGE, the voxel-wise and VOI analyses showed a significant increase of F-A-85380 ratio index of binding potential (BPRI, corresponding to the receptor availability) in the anterior cingulate cortex (ACC), without structural changes on MRI. At an individual level, F-A-85380 BPRI increase in the ACC could distinguish IGE patients from controls and from patients with focal epilepsy with good accuracy.Conclusions: We observed focal changes of density/availability of nicotinic receptors in IGE, namely an increase in the ACC. These data suggest that the modulation of α4β2 nicotinic receptors plays a role not only in ADNFLE, but also in other genetic epileptic syndromes such as IGE and could serve as a biomarker of epilepsy syndromes with a genetic background.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- F-A-85380
- Focal epilepsy
- Idiopathic generalized epilepsy
- Nicotinic receptors
- PET
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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