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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
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| 008 | 240701s2016 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-122103 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1333156522 URI |
| 024 | 7 | a https://doi.org/10.1038/ncomms109792 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1221032 URI |
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| 100 | 1 | a Gusev, A4 aut |
| 245 | 1 0 | a Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation |
| 264 | c 2016-04-07 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 520 | a Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
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| 700 | 1 | a Leske, MC4 aut |
| 700 | 1 | a Wu, SY4 aut |
| 700 | 1 | a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,Urologi och andrologi4 aut0 (Swepub:umu)masmas97 |
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| 700 | 1 | a Fitzgerald, LM4 aut |
| 700 | 1 | a Gronberg, Hu Karolinska Institutet4 aut |
| 700 | 1 | a Wiklund, Fu Karolinska Institutet4 aut |
| 700 | 1 | a Aly, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Henderson, BE4 aut |
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| 700 | 1 | a Paulo, P4 aut |
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| 710 | 2 | a Karolinska Institutetb Enheten för biobanksforskning4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 7, s. 10979-q 7<10979-x 2041-1723 |
| 856 | 4 | u https://doi.org/10.1038/ncomms10979 |
| 856 | 4 | u https://doi.org/10.1038/ncomms10979y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:937255/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133315652 |
| 856 | 4 8 | u https://doi.org/10.1038/ncomms10979 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122103 |
Hitta mer i SwePub
- Av författaren/redakt...
- Gusev, A
- Shi, H
- Kichaev, G
- Pomerantz, M
- Li, F
- Long, HW
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- Ingles, SA
- Kittles, RA
- Strom, SS
- Rybicki, BA
- Nemesure, B
- Isaacs, WB
- Zheng, W
- Pettaway, CA
- Yeboah, ED
- Tettey, Y
- Biritwum, RB
- Adjei, AA
- Tay, E
- Truelove, A
- Niwa, S
- Chokkalingam, AP
- John, EM
- Murphy, AB
- Signorello, LB
- Carpten, J
- Leske, MC
- Wu, SY
- Johansson, Matti ...
- Neslund-Dudas, C
- Hsing, AW
- Chu, L
- Goodman, PJ
- Klein, EA
- Witte, JS
- Casey, G
- Kaggwa, S
- Cook, MB
- Stram, DO
- Blot, WJ
- Eeles, RA
- Easton, D
- Kote-Jarai, Z
- Al Olama, AA
- Benlloch, S
- Muir, K
- Giles, GG
- Southey, MC
- Fitzgerald, LM
- Gronberg, H
- Wiklund, F
- Aly, M
- Henderson, BE
- Schleutker, J
- Wahlfors, T
- Tammela, TLJ
- Nordestgaard, BG
- Key, TJ
- Travis, RC
- Neal, DE
- Donovan, JL
- Hamdy, FC
- Pharoah, P
- Pashayan, N
- Khaw, KT
- Stanford, JL
- Thibodeau, SN
- McDonnell, SK
- Schaid, DJ
- Maier, C
- Vogel, W
- Luedeke, M
- Herkommer, K
- Kibel, AS
- Cybulski, C
- Wokolorczyk, D
- Kluzniak, W
- Cannon-Albright, ...
- Teerlink, C
- Brenner, H
- Dieffenbach, AK
- Arndt, V
- Park, JY
- Sellers, TA
- Lin, HY
- Slavov, C
- Kaneva, R
- Mitev, V
- Batra, J
- Spurdle, A
- Clements, JA
- Teixeira, MR
- Pandha, H
- Michael, A
- Paulo, P
- Maia, S
- Kierzek, A
- Conti, DV
- Albanes, D
- Berg, C
- Berndt, SI
- Campa, D
- Crawford, ED
- Diver, WR
- Gapstur, SM
- Gaziano, JM
- Giovannucci, E
- Hoover, R
- Hunter, DJ
- Johansson, M
- Kraft, P
- Le Marchand, L
- Lindstrom, S
- Navarro, C
- Overvad, K
- Riboli, E
- Siddiq, A
- Stevens, VL
- Trichopoulos, D
- Vineis, P
- Yeager, M
- Trynka, G
- Raychaudhuri, S
- Schumacher, FR
- Price, AL
- Freedman, ML
- Haiman, CA
- Pasaniuc, B
- Cook, M
- Guy, M
- Govindasami, K
- Leongamornlert, ...
- Sawyer, EJ
- Wilkinson, R
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- Tymrakiewicz, M
- Dadaev, T
- Morgan, A
- Fisher, C
- Hazel, S
- Livni, N
- Lophatananon, A
- Pedersen, J
- Hopper, JL
- Adolfson, J
- Stattin, P
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- Cavalli-Bjoerkma ...
- Karlsson, A
- Broms, M
- Auvinen, A
- Kujala, P
- Maeaettaenen, L
- Murtola, T
- Taari, K
- Weischer, M
- Nielsen, SF
- Klarskov, P
- Roder, A
- Iversen, P
- Wallinder, H
- Gustafsson, S
- Cox, A
- Brown, P
- George, A
- Marsden, G
- Lane, A
- Davis, M
- Tillmans, L
- Riska, S
- Wang, L
- Rinckleb, A
- Lubiski, J
- Stegmaier, C
- Pow-Sang, J
- Park, H
- Radlein, S
- Rincon, M
- Haley, J
- Zachariah, B
- Kachakova, D
- Popov, E
- Mitkova, A
- Vlahova, A
- Dikov, T
- Christova, S
- Heathcote, P
- Wood, G
- Malone, G
- Saunders, P
- Eckert, A
- Yeadon, T
- Kerr, K
- Collins, A
- Turner, M
- Srinivasan, S
- Kedda, MA
- Alexander, K
- Omara, T
- Wu, HH
- Henrique, R
- Pinto, P
- Santos, J
- Barros-Silva, J
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