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Sökning: WFRF:(Siebert Reiner) > (2015-2019) > Alterations of the ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003265naa a2200445 4500
001oai:DiVA.org:uu-261927
003SwePub
008150907s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2619272 URI
0247 a https://doi.org/10.1002/gcc.222762 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Schneider, Markus4 aut
2451 0a Alterations of the CD58 gene in classical Hodgkin lymphoma
264 c 2015-07-21
264 1b Wiley,c 2015
338 a print2 rdacarrier
520 a Immune evasion plays a central role in the pathophysiology of classical Hodgkin lymphoma (cHL). As mutations of the CD58 gene contribute to immune evasion of diffuse large B cell lymphoma tumor cells, we studied whether alterations of the CD58 gene also occur in Hodgkin and Reed/Sternberg (HRS) cells of cHL. Single nucleotide polymorphism chip analysis revealed homozygous deletions within the CD58 gene in two cHL cell lines (SUP-HD1 and U-HO1). Sequencing of the CD58 gene in seven cHL cell lines disclosed in addition a homozygous splice site mutation in cell line KM-H2. None of the three mutated lines expressed CD58 protein on their surface. Thus, three of seven cHL cell lines analyzed harbor destructive CD58 mutations. Molecular analysis of isolated HRS cells from 10 primary cases of cHL; however, did not reveal any case with a CD58 mutation. A FICTION study indicated heterozygous deletions of CD58 in 3 of 13 cHL analyzed. Overall, we report frequent inactivating mutations of CD58 in cHL cell lines, but their rare occurrence in primary HRS cells. As the three cHL cell lines with CD58 mutations were all established from HRS cells located in pleural effusions, i.e., outside the normal lymph node microenvironment, in end-stages of the disease, CD58 inactivation in cHL might be predominantly prevalent to such situations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Patologi
653 a Pathology
7001 a Schneider, Stefanie4 aut
7001 a Zuehlke-Jenisch, Reina4 aut
7001 a Klapper, Wolfram4 aut
7001 a Sundström, Christeru Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)chrisund
7001 a Hartmann, Sylvia4 aut
7001 a Hansmann, Martin-Leo4 aut
7001 a Siebert, Reiner4 aut
7001 a Kueppers, Ralf4 aut
7001 a Giefing, Maciej4 aut
7102 a Uppsala universitetb Klinisk och experimentell patologi4 org
7730 t Genes, Chromosomes and Cancerd : Wileyg 54:10, s. 638-645q 54:10<638-645x 1045-2257x 1098-2264
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261927
8564 8u https://doi.org/10.1002/gcc.22276

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