WFRF:(Stender S.)
Sökning: WFRF:(Stender S.) > Causal relationship...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04706naa a2200601 4500 | |
| 001 | oai:gup.ub.gu.se/266060 | |
| 003 | SwePub | |
| 008 | 240528s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2660602 URI |
| 024 | 7 | a https://doi.org/10.1111/joim.127192 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Dongiovanni, P4 aut |
| 245 | 1 0 | a Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver. |
| 264 | c 2017-12-27 | |
| 264 | 1 | b Wiley,c 2018 |
| 520 | a Nonalcoholic fatty liver disease is epidemiologically associated with hepatic and metabolic disorders. The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance.We performed a Mendelian randomization analysis using risk alleles in PNPLA3, TM6SF2, GCKR and MBOAT7, and a polygenic risk score for hepatic fat, as instruments. We evaluated complementary cohorts of at-risk individuals and individuals from the general population: 1515 from the liver biopsy cohort (LBC), 3329 from the Swedish Obese Subjects Study (SOS) and 4570 from the population-based Dallas Heart Study (DHS).Hepatic fat was epidemiologically associated with liver damage, insulin resistance, dyslipidemia and hypertension. The impact of genetic variants on liver damage was proportional to their effect on hepatic fat accumulation. Genetically determined hepatic fat was associated with aminotransferases, and with inflammation, ballooning and fibrosis in the LBC. Furthermore, in the LBC, the causal association between hepatic fat and fibrosis was independent of disease activity, suggesting that a causal effect of long-term liver fat accumulation on liver disease is independent of inflammation. Genetically determined hepatic steatosis was associated with insulin resistance in the LBC and SOS. However, this association was dependent on liver damage severity. Genetically determined hepatic steatosis was associated with liver fibrosis/cirrhosis and with a small increase in risk of type 2 diabetes in publicly available databases.These data suggest that long-term hepatic fat accumulation plays a causal role in the development of chronic liver disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a fibrosis | |
| 653 | a genetics | |
| 653 | a insulin resistance | |
| 653 | a mendelian randomization | |
| 653 | a nonalcoholic fatty liver disease | |
| 653 | a type 2 diabetes | |
| 700 | 1 | a Stender, S4 aut |
| 700 | 1 | a Pietrelli, A4 aut |
| 700 | 1 | a Mancina, Rosellina Margheritau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xmanro |
| 700 | 1 | a Cespiati, A4 aut |
| 700 | 1 | a Petta, S4 aut |
| 700 | 1 | a Pelusi, S4 aut |
| 700 | 1 | a Pingitore, Piero,d 1986u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xpinpi |
| 700 | 1 | a Badiali, S4 aut |
| 700 | 1 | a Maggioni, M4 aut |
| 700 | 1 | a Mannisto, V4 aut |
| 700 | 1 | a Grimaudo, S4 aut |
| 700 | 1 | a Pipitone, R M4 aut |
| 700 | 1 | a Pihlajamaki, J4 aut |
| 700 | 1 | a Craxi, A4 aut |
| 700 | 1 | a Taube, Magdalena4 aut |
| 700 | 1 | a Carlsson, Lena M S,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xcarle |
| 700 | 1 | a Fargion, S4 aut |
| 700 | 1 | a Romeo, Stefano,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xroste |
| 700 | 1 | a Kozlitina, J4 aut |
| 700 | 1 | a Valenti, L4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
| 773 | 0 | t Journal of internal medicined : Wileyg 283:4, s. 356-370q 283:4<356-370x 1365-2796x 1365-2796x 0954-6820 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.12719 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/266060 |
| 856 | 4 8 | u https://doi.org/10.1111/joim.12719 |
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