WFRF:(Sun Yanyan)
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Systemic stimulation of TLR2 impairs neonatal mouse brain development.
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- Du, Xiaonan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Fleiss, Bobbi (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Li, Hongfu (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Levy, Ofer (author)
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- (creator_code:org_t)
- 2011-05-06
- 2011
- English.
- In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 6:5
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Inflammation is associated with perinatal brain injury but the underlying mechanisms are not completely characterized. Stimulation of Toll-like receptors (TLRs) through specific agonists induces inflammatory responses that trigger both innate and adaptive immune responses. The impact of engagement of TLR2 signaling pathways on the neonatal brain is still unclear. The aim of this study was to investigate the potential effect of a TLR2 agonist on neonatal brain development.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
Keyword
- Aging
- drug effects
- Animals
- Animals
- Newborn
- Apoptosis
- drug effects
- Brain
- drug effects
- growth & development
- immunology
- pathology
- Cell Proliferation
- drug effects
- Cytokines
- biosynthesis
- Hippocampus
- drug effects
- pathology
- Inflammation
- pathology
- Learning
- drug effects
- Lipopeptides
- administration & dosage
- pharmacology
- Liver
- anatomy & histology
- drug effects
- Mice
- Mice
- Inbred C57BL
- Microglia
- drug effects
- pathology
- Organ Size
- drug effects
- Spleen
- anatomy & histology
- drug effects
- Toll-Like Receptor 2
- deficiency
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- About the subject
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- AGRICULTURAL SCIENCES
- AGRICULTURAL SCI ...
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- Articles in the publication
- PloS one
- By the university
- University of Gothenburg
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