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WFRF:(Szalai Z.)
 

Sökning: WFRF:(Szalai Z.) > Histidine decarboxy...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003690naa a2200529 4500
001oai:DiVA.org:uu-421725
003SwePub
008201012s2000 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4217252 URI
0247 a https://doi.org/10.1046/j.1523-1747.2000.00054.x2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Haak-Frendscho, M4 aut
2451 0a Histidine decarboxylase expression in human melanoma.
264 1b Elsevier BV,c 2000
338 a print2 rdacarrier
520 a Histamine has been implicated as one of the mediators involved in regulation of proliferation in both normal and neoplastic tissues. Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels. In this study, we investigated the gene and protein expression of histidine decarboxylase in melanoma. Reverse transcriptase polymerase chain reaction and in situ hybridization studies of WM-35, WM-983/B, HT-168, and M1 human melanoma cell lines both resulted in positive signals for histidine decarboxylase messenger RNA. A polyclonal chicken antibody was developed against human histidine decarboxylase and protein expression was confirmed by western blot analysis of the cell lysates, revealing a predominant immunoreactive band at approximately 54 kDa corresponding to monomeric histidine decarboxylase. Protein expression of histidine decarboxylase was also shown by flow cytometric analysis and strong punctate cytoplasmic staining of melanoma cell lines. Moreover, both primary and metastatic human melanoma tissues were brightly stained for histidine decarboxylase. When compared with the very weak or no reactions on cultivated human melanocytes both western blot and immunohistochemical studies showed much stronger histidine decarboxylase expression in melanoma cells. These findings suggest that expression of histidine decarboxylase is elevated in human melanoma.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
7001 a Darvas, Z4 aut
7001 a Hegyesi, H4 aut
7001 a Kárpáti, S4 aut
7001 a Hoffman, R L4 aut
7001 a László, V4 aut
7001 a Bencsáth, M4 aut
7001 a Szalai, C4 aut
7001 a Fürész, J4 aut
7001 a Timár, J4 aut
7001 a Bata-Csörgõ, Z4 aut
7001 a Szabad, G4 aut
7001 a Pivarcsi, A4 aut
7001 a Pállinger, E4 aut
7001 a Kemény, L4 aut
7001 a Horváth, A4 aut
7001 a Dobozy, A4 aut
7001 a Falus, A4 aut
7730 t Journal of Investigative Dermatologyd : Elsevier BVg 115:3, s. 345-52q 115:3<345-52x 0022-202Xx 1523-1747
8564 u http://www.jidonline.org/article/S0022202X15409789/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421725
8564 8u https://doi.org/10.1046/j.1523-1747.2000.00054.x

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