Sökning: WFRF:(Tay Eng Hseon) > Four year efficacy ...
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000 | 06408naa a2200901 4500 | |
001 | oai:lup.lub.lu.se:093e1a6c-880e-45a9-947d-9596e2730fa2 | |
003 | SwePub | |
008 | 160404s2010 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:121044802 | |
024 | 7 | a https://lup.lub.lu.se/record/16446642 URI |
024 | 7 | a https://doi.org/10.1136/bmj.c34932 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1210448022 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Dillner, Joakimu Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-jdi |
245 | 1 0 | a Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial. |
264 | c 2010-07-20 | |
264 | 1 | b BMJ,c 2010 |
338 | a electronic2 rdacarrier | |
520 | a OBJECTIVES: To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). DESIGN: Data from two international, double blind, placebo controlled, randomised efficacy trials of quadrivalent HPV vaccine (protocol 013 (FUTURE I) and protocol 015 (FUTURE II)). The trials were to be 4 years in length, and the results reported are from final study data of 42 months' follow-up. SETTING: Primary care centres and university or hospital associated health centres in 24 countries and territories around the world. PARTICIPANTS: 17 622 women aged 16-26 years enrolled between December 2001 and May 2003. Major exclusion criteria were lifetime number of sexual partners (>4), history of abnormal cervical smear test results, and pregnancy. INTERVENTION: Three doses of quadrivalent HPV vaccine (for serotypes 6, 11, 16, and 18) or placebo at day 1, month 2, and month 6. MAIN OUTCOME MEASURES: Vaccine efficacy against cervical, vulvar, and vaginal intraepithelial neoplasia grade I and condyloma in a per protocol susceptible population that included subjects who received all three vaccine doses, tested negative for the relevant vaccine HPV types at day 1 and remained negative through month 7, and had no major protocol violations. Intention to treat, generally HPV naive, and unrestricted susceptible populations were also studied. RESULTS: In the per protocol susceptible population, vaccine efficacy against lesions related to the HPV types in the vaccine was 96% for cervical intraepithelial neoplasia grade I (95% confidence interval 91% to 98%), 100% for both vulvar and vaginal intraepithelial neoplasia grade I (95% CIs 74% to 100%, 64% to 100% respectively), and 99% for condyloma (96% to 100%). Vaccine efficacy against any lesion (regardless of HPV type) in the generally naive population was 30% (17% to 41%), 75% (22% to 94%), and 48% (10% to 71%) for cervical, vulvar, and vaginal intraepithelial neoplasia grade I, respectively, and 83% (74% to 89%) for condyloma. CONCLUSIONS: Quadrivalent HPV vaccine provided sustained protection against low grade lesions attributable to vaccine HPV types (6, 11, 16, and 18) and a substantial reduction in the burden of these diseases through 42 months of follow-up. TRIAL REGISTRATIONS: NCT00092521 and NCT00092534. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
653 | a Vaginal Neoplasms: prevention & control | |
653 | a Uterine Cervical Neoplasms: prevention & control | |
653 | a Urogenital Neoplasms: prevention & control | |
653 | a Papillomavirus Infections: prevention & control | |
653 | a Condylomata Acuminata: prevention & control | |
653 | a Carcinoma in Situ: prevention & control | |
653 | a Cervical Intraepithelial Neoplasia: prevention & control | |
653 | a Vulvar Neoplasms: prevention & control | |
700 | 1 | a Kjaer, Susanne K4 aut |
700 | 1 | a Wheeler, Cosette M4 aut |
700 | 1 | a Sigurdsson, Kristján4 aut |
700 | 1 | a Iversen, Ole-Erik4 aut |
700 | 1 | a Hernandez-Avila, Mauricio4 aut |
700 | 1 | a Perez, Gonzalo4 aut |
700 | 1 | a Brown, Darron R4 aut |
700 | 1 | a Koutsky, Laura A4 aut |
700 | 1 | a Tay, Eng Hseon4 aut |
700 | 1 | a García, Patricia4 aut |
700 | 1 | a Ault, Kevin A4 aut |
700 | 1 | a Garland, Suzanne M4 aut |
700 | 1 | a Leodolter, Sepp4 aut |
700 | 1 | a Olsson, Sven-Ericu Karolinska Institutet4 aut |
700 | 1 | a Tang, Grace W K4 aut |
700 | 1 | a Ferris, Daron G4 aut |
700 | 1 | a Paavonen, Jorma4 aut |
700 | 1 | a Lehtinen, Matti4 aut |
700 | 1 | a Steben, Marc4 aut |
700 | 1 | a Bosch, F Xavier4 aut |
700 | 1 | a Joura, Elmar A4 aut |
700 | 1 | a Majewski, Slawomir4 aut |
700 | 1 | a Muñoz, Nubia4 aut |
700 | 1 | a Myers, Evan R4 aut |
700 | 1 | a Villa, Luisa L4 aut |
700 | 1 | a Taddeo, Frank J4 aut |
700 | 1 | a Roberts, Christine4 aut |
700 | 1 | a Tadesse, Amha4 aut |
700 | 1 | a Bryan, Janine T4 aut |
700 | 1 | a Maansson, Roger4 aut |
700 | 1 | a Lu, Shuang4 aut |
700 | 1 | a Vuocolo, Scott4 aut |
700 | 1 | a Hesley, Teresa M4 aut |
700 | 1 | a Barr, Eliav4 aut |
700 | 1 | a Haupt, Richard4 aut |
710 | 2 | a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t BMJ: British Medical Journald : BMJg 341q 341x 1756-1833x 0959-8138x 1468-5833 |
773 | 0 | t BMJd : BMJg 341q 341x 0959-8138x 1468-5833 |
856 | 4 | u https://portal.research.lu.se/files/5364347/1660582.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/20647284?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1136/bmj.c3493y FULLTEXT |
856 | 4 | u https://www.bmj.com/content/341/bmj.c3493.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1644664 |
856 | 4 8 | u https://doi.org/10.1136/bmj.c3493 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121044802 |
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