Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

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Fältnamn	Indikatorer	Metadata
000		05219naa a2201153 4500
001		oai:DiVA.org:uu-124381
003		SwePub
008		100503s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1243812 URI
024	7	a https://doi.org/10.1038/ng.3232 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Gudbjartsson, Daniel F.4 aut
245	1 0	a Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
264		c 2009-02-08
264	1	b Springer Science and Business Media LLC,c 2009
338		a print2 rdacarrier
520		a Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
653		a MEDICINE
653		a MEDICIN
700	1	a Bjornsdottir, Unnur S.4 aut
700	1	a Halapi, Eva4 aut
700	1	a Helgadottir, Anna4 aut
700	1	a Sulem, Patrick4 aut
700	1	a Jonsdottir, Gudrun M.4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Helgadottir, Hafdis4 aut
700	1	a Steinthorsdottir, Valgerdur4 aut
700	1	a Stefansson, Hreinn4 aut
700	1	a Williams, Carolyn4 aut
700	1	a Hui, Jennie4 aut
700	1	a Beilby, John4 aut
700	1	a Warrington, Nicole M.4 aut
700	1	a James, Alan4 aut
700	1	a Palmer, Lyle J.4 aut
700	1	a Koppelman, Gerard H.4 aut
700	1	a Heinzmann, Andrea4 aut
700	1	a Krueger, Marcus4 aut
700	1	a Boezen, H. Marike4 aut
700	1	a Wheatley, Amanda4 aut
700	1	a Altmuller, Janine4 aut
700	1	a Shin, Hyoung Doo4 aut
700	1	a Uh, Soo-Taek4 aut
700	1	a Cheong, Hyun Sub4 aut
700	1	a Jonsdottir, Brynja4 aut
700	1	a Gislason, David4 aut
700	1	a Park, Choon-Sik4 aut
700	1	a Rasmussen, Linda M.4 aut
700	1	a Porsbjerg, Celeste4 aut
700	1	a Hansen, Jakob W.4 aut
700	1	a Backer, Vibeke4 aut
700	1	a Werge, Thomas4 aut
700	1	a Janson, Christeru Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn
700	1	a Jönsson, Ulla-Brittu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)ullabjon
700	1	a Ng, Maggie C. Y.4 aut
700	1	a Chan, Juliana4 aut
700	1	a So, Wing Yee4 aut
700	1	a Ma, Ronald4 aut
700	1	a Shah, Svati H.4 aut
700	1	a Granger, Christopher B.4 aut
700	1	a Quyyumi, Arshed A.4 aut
700	1	a Levey, Allan I.4 aut
700	1	a Vaccarino, Viola4 aut
700	1	a Reilly, Muredach P.4 aut
700	1	a Rader, Daniel J.4 aut
700	1	a Williams, Michael J. A.4 aut
700	1	a van Rij, Andre M.4 aut
700	1	a Jones, Gregory T.4 aut
700	1	a Trabetti, Elisabetta4 aut
700	1	a Malerba, Giovanni4 aut
700	1	a Pignatti, Pier Franco4 aut
700	1	a Boner, Attilio4 aut
700	1	a Pescollderungg, Lydia4 aut
700	1	a Girelli, Domenico4 aut
700	1	a Olivieri, Oliviero4 aut
700	1	a Martinelli, Nicola4 aut
700	1	a Ludviksson, Bjorn R.4 aut
700	1	a Ludviksdottir, Dora4 aut
700	1	a Eyjolfsson, Gudmundur I.4 aut
700	1	a Arnar, David4 aut
700	1	a Thorgeirsson, Gudmundur4 aut
700	1	a Deichmann, Klaus4 aut
700	1	a Thompson, Philip J.4 aut
700	1	a Wjst, Matthias4 aut
700	1	a Hall, Ian P.4 aut
700	1	a Postma, Dirkje S.4 aut
700	1	a Gislason, Thorarinn4 aut
700	1	a Gulcher, Jeffrey4 aut
700	1	a Kong, Augustine4 aut
700	1	a Jonsdottir, Ingileif4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Stefansson, Kari4 aut
710	2	a Uppsala universitetb Lungmedicin och allergologi4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 41:3, s. 342-347q 41:3<342-347x 1061-4036x 1546-1718
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124381
856	4 8	u https://doi.org/10.1038/ng.323

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Av författaren/redakt...: Gudbjartsson, Da ...; Bjornsdottir, Un ...; Halapi, Eva; Helgadottir, Ann ...; Sulem, Patrick; Jonsdottir, Gudr ...; visa fler...; Thorleifsson, Gu ...; Helgadottir, Haf ...; Steinthorsdottir ...; Stefansson, Hrei ...; Williams, Caroly ...; Hui, Jennie; Beilby, John; Warrington, Nico ...; James, Alan; Palmer, Lyle J.; Koppelman, Gerar ...; Heinzmann, Andre ...; Krueger, Marcus; Boezen, H. Marik ...; Wheatley, Amanda; Altmuller, Janin ...; Shin, Hyoung Doo; Uh, Soo-Taek; Cheong, Hyun Sub; Jonsdottir, Bryn ...; Gislason, David; Park, Choon-Sik; Rasmussen, Linda ...; Porsbjerg, Celes ...; Hansen, Jakob W.; Backer, Vibeke; Werge, Thomas; Janson, Christer; Jönsson, Ulla-Br ...; Ng, Maggie C. Y.; Chan, Juliana; So, Wing Yee; Ma, Ronald; Shah, Svati H.; Granger, Christo ...; Quyyumi, Arshed ...; Levey, Allan I.; Vaccarino, Viola; Reilly, Muredach ...; Rader, Daniel J.; Williams, Michae ...; van Rij, Andre M ...; Jones, Gregory T ...; Trabetti, Elisab ...; Malerba, Giovann ...; Pignatti, Pier F ...; Boner, Attilio; Pescollderungg, ...; Girelli, Domenic ...; Olivieri, Olivie ...; Martinelli, Nico ...; Ludviksson, Bjor ...; Ludviksdottir, D ...; Eyjolfsson, Gudm ...; Arnar, David; Thorgeirsson, Gu ...; Deichmann, Klaus; Thompson, Philip ...; Wjst, Matthias; Hall, Ian P.; Postma, Dirkje S ...; Gislason, Thorar ...; Gulcher, Jeffrey; Kong, Augustine; Jonsdottir, Ingi ...; Thorsteinsdottir ...; Stefansson, Kari; visa färre...

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