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The Prevalence and ...
The Prevalence and Determinants of Neuropsychiatric Symptoms in Late-Stage Parkinsonism
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- Hommel, Adrianus L.A.J. (författare)
- Groenhuysen,Radboud University Medical Center
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- Meinders, Marjan J. (författare)
- Radboud University Medical Center
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- Lorenzl, Stefan (författare)
- Ludwig-Maximilian University of Munich,University Hospital Munich,Paracelsus Private Medical University of Salzburg
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- Dodel, Richard (författare)
- University Hospital Essen
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- Coelho, Miguel (författare)
- University of Lisbon,Santa Maria Hospital, Lisbon
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- Ferreira, Joaquim J. (författare)
- University of Lisbon
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- Laurens, Brice (författare)
- University of Bordeaux,Centre Hospitalier Universitaire de Bordeaux
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- Spampinato, Umberto (författare)
- Centre Hospitalier Universitaire de Bordeaux,University of Bordeaux
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- Meissner, Wassilios (författare)
- University of Bordeaux,University of Otago,Centre Hospitalier Universitaire de Bordeaux,New Zealand Brain Research Institute
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- Rosqvist, Kristina (författare)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Timpka, Jonathan (författare)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Odin, Per (författare)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Wittenberg, Michael (författare)
- Philipp University of Marburg
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- Bloem PhD, Bas R. (författare)
- Radboud University Medical Center
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- Koopmans, Raymond T. (författare)
- Joachim en Anna, Center for Specialized Geriatric Care,Radboud University Medical Center
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- Schrag, Anette (författare)
- University College London
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(creator_code:org_t)
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- 2020-05-21
- 2020
- Engelska 12 s.
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Ingår i: Movement Disorders Clinical Practice. - : Wiley. - 2330-1619. ; 7:5, s. 531-542
- Relaterad länk:
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http://dx.doi.org/10...
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https://movementdiso...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Late-stage parkinsonism and Parkinson's disease (PD) are insufficiently studied population. Although neuropsychiatric symptoms (eg, psychosis, depression, anxiety, behavioral problems) are frequently present, their prevalence and clinical predictors remain unknown. Objective: To determine the prevalence and predictors of neuropsychiatric symptoms in late-stage PD. Methods: We conducted a multinational study of patients with PD with ≥7 years disease duration and either a Hoehn and Yahr stage ≥4 or a Schwab and England score ≤ 50% in the on stage. Neuropsychiatric symptoms were assessed through interviews with carers using the Neuropsychiatric Inventory, with a frequency × severity score ≥ 4, indicating clinically relevant symptoms. The determinants analyzed were demographic characteristics, medication, and motor and nonmotor symptoms. Univariate and multivariate logistic analyses were performed on predictors of clinically relevant neuropsychiatric symptoms. Results: A total of 625 patients were recruited in whom the Neuropsychiatric Inventory could be completed. In 92.2% (576/625) of the patients, at least 1 neuropsychiatric symptom was present, and 75.5% (472/625) had ≥1 clinically relevant symptom. The most common clinically relevant symptoms were apathy (n = 242; 38.9%), depression (n = 213; 34.5%), and anxiety (n = 148; 23.8%). The multivariate analysis revealed unique sets of predictors for each symptom, particularly the presence of other neuropsychiatric features, cognitive impairment, daytime sleepiness. Conclusion: Neuropsychiatric symptoms are common in late-stage PD. The strongest predictors are the presence of other neuropsychiatric symptoms. Clinicians involved in the care for patients with late-stage PD should be aware of these symptoms in this specific disease group and proactively explore other psychiatric comorbidities once a neuropsychiatric symptom is recognized.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- depression
- late-stage parkinsonism
- neuropsychiatric symptoms
- prevalence
- psychosis
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- Av författaren/redakt...
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Hommel, Adrianus ...
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Meinders, Marjan ...
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Lorenzl, Stefan
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Dodel, Richard
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Coelho, Miguel
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Ferreira, Joaqui ...
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Laurens, Brice
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Spampinato, Umbe ...
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Meissner, Wassil ...
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Rosqvist, Kristi ...
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Timpka, Jonathan
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Odin, Per
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Wittenberg, Mich ...
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Bloem PhD, Bas R ...
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Koopmans, Raymon ...
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Schrag, Anette
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
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Movement Disorde ...
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Lunds universitet