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FältnamnIndikatorerMetadata
00008755naa a2200793 4500
001oai:DiVA.org:uu-423469
003SwePub
008201104s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-176194
009oai:prod.swepub.kib.ki.se:144859595
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4234692 URI
024a https://doi.org/10.1158/1055-9965.EPI-20-03542 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1761942 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1448595952 URI
040 a (SwePub)uud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Fortner, Renee T.u German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Deutsch Krebsforschungszentrum DKFZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.4 aut
2451 0a Ovarian Cancer Risk Factor Associations by Primary Anatomic Site :b The Ovarian Cancer Cohort Consortium
264 1b American Association for Cancer Research (AACR),c 2020
338 a print2 rdacarrier
520 a Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites.Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests.Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases.Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site.Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
700a Rice, Megan S.u Massachusetts Gen Hosp, Dept Med, Clin & Translat Epidemiol Unit, Harvard Med Sch, Boston, MA USA.4 aut
700a Knutsen, Synnove F.u Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA USA.4 aut
700a Orlich, Michael J.u Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA USA.4 aut
700a Visvanathan, Kalau Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.;Johns Hopkins Bloomberg Sch Med, Baltimore, MD USA.4 aut
700a Patel, Alpa, Vu Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA USA.4 aut
700a Gaudet, Mia M.u Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA USA.4 aut
700a Tjønneland, Anneu Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.;Danish Canc Soc Res Ctr, Diet Genes & Environm, Copenhagen, Denmark.4 aut
700a Kvaskoff, Marinau Univ Paris Saclay, Fac Med Univ Paris Sud, Fac Med UVSQ, INSERM,CESP, Villejuif, France.;Gustave Roussy, Villejuif, France.4 aut
700a Kaaks, Rudolfu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Deutsch Krebsforschungszentrum DKFZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.4 aut
700a Trichopolou, Antoniau Hellen Hlth Fdn, Athens, Greece.4 aut
700a Pala, Valeriau Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Milan, Italy.4 aut
700a Onland-Moret, N. Charlotteu Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut
700a Gram, Inger T.u Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway.4 aut
700a Amiano, Pilaru BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain.;CIBER Epidemiol & Salud Publ, Madrid, Spain.4 aut
700a Idahl, Annika,d 1965-u Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci Obstet & Gynecol, Umeå, Sweden.4 aut0 (Swepub:umu)anid0002
700a Allen, Naomi E.u Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.4 aut
700a Weiderpass, Elisabeteu Int Agcy Res Canc, Lyon, France.4 aut
700a Poynter, Jenny N.u Univ Minnesota, Div Pediat Epidemiol & Clin Res, Minneapolis, MN USA.4 aut
700a Robien, Kimu George Washington Univ, Milken Inst Sch Publ Hlth, Dept Exercise & Nutr Sci, Washington, DC USA.4 aut
700a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut
700a Milne, Roger L.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut
700a Setiawan, Veronica W.u Univ Southern Calif, Los Angeles, CA 90007 USA.4 aut
700a Merritt, Melissa A.u Univ Hawaii, Canc Epidemiol Program, Canc Ctr, Honolulu, HI USA.4 aut
700a van den Brandt, Piet A.u Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands.,NYU, Sch Med, New York, NY USA.4 aut
700a Zeleniuch-Jacquotte, Anneu NYU, Sch Med, New York, NY USA.4 aut
700a Arslan, Alan A.u NYU, Sch Med, New York, NY USA.4 aut
700a O'Brien, Katie M.u Natl Inst Environm Hlth Sci, Epidemiol Branch, Durham, NC USA.4 aut
700a Sandler, Dale P.u Natl Inst Environm Hlth Sci, Epidemiol Branch, Durham, NC USA.4 aut
700a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 aut0 (Swepub:uu)alwol516
700a Håkansson, Niclasu Karolinska Institutet4 aut
700a Harris, Holly R.u Fred Hutchinson Canc Res Ctr, Program Epidemiol, Washington, DC USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Washington, DC USA.4 aut
700a Trabert, Brittonu NIH, Div Canc Epidemiol & Genet, NCI, Washington, DC USA.4 aut
700a Wentzensen, Nicolasu NIH, Div Canc Epidemiol & Genet, NCI, Washington, DC USA.4 aut
700a Tworoger, Shelley S.u H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.4 aut
700a Schouten, Leo J.u Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands.4 aut
710a German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Deutsch Krebsforschungszentrum DKFZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.b Massachusetts Gen Hosp, Dept Med, Clin & Translat Epidemiol Unit, Harvard Med Sch, Boston, MA USA.4 org
773t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Research (AACR)g 29:10, s. 2010-2018q 29:10<2010-2018x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423469
8564 8u https://doi.org/10.1158/1055-9965.EPI-20-0354
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176194
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144859595

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