Hyperandrogenic symptoms are a persistent suffering in midlife women with pcos; a prospective cohort study in sweden

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and the majority suffers from hyperandrogenism. Hyperandrogenism causes psychological morbidity and impaired quality of life in women with PCOS during the reproductive years, but data on prevalence and impact during midlife are lacking. Thus, this study aimed to address whether hyperandrogenism persists into midlife and, if so, what impact it has on quality of life. In order to answer this question, we performed a multicenter prospective cohort study, where we included women already diagnosed with PCOS who had reached the age of 45 years or more and age-matched controls. All participants underwent a physical exam, structured medical interview, biochemical testing and filled out self-assessment questionnaires. More than 40% of the women with PCOS and 82% of those who presented with the hyperandrogenic phenotype at the diagnostic work-up still suffered from hirsutism. Circulating testosterone levels were similar between women with PCOS and controls while free androgen index was higher in women with PCOS, independent of weight. Women with hyperandrogenic PCOS expressed persisting concerns regarding hirsutism at the follow-up assessment. In conclusion, women with PCOS who present with hyperandrogenic symptoms at the time they are diagnosed with PCOS have a higher risk of persistent androgenic symptoms and impaired quality of life in midlife.

Ubhayasekera, KumariUppsala universitet,Analytisk kemi(Swepub:uu)kumub884 (författare)
Bergquist, JonasUppsala universitet,Analytisk kemi(Swepub:uu)jbe25356 (författare)
Turkmen, SahruhUmeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci Obstet & Gynecol, Sundsvalls Res Unit, S-90185 Umeå, Sweden.(Swepub:umu)satu0001 (författare)
Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (författare)
Elenis, Evangelia,1983-Uppsala universitet,Reproduktiv hälsa,Uppsala Univ Hosp, Reprod Ctr, Womens Clin, S-75185 Uppsala, Sweden.(Swepub:uu)evael941 (författare)
Uppsala universitetReproduktiv hälsa (creator_code:org_t)

Av författaren/redakt...: Persson, Sofia; Ubhayasekera, Ku ...; Bergquist, Jonas; Turkmen, Sahruh; Sundström Poroma ...; Elenis, Evangeli ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

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