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Sökning: WFRF:(Vacchi A) > (2020) > Size-Dependent Pulm...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003712naa a2200565 4500
001oai:DiVA.org:su-181934
003SwePub
008200616s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:143601386
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1819342 URI
0247 a https://doi.org/10.1002/advs.2019032002 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1436013862 URI
040 a (SwePub)sud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rodrigues, Artur Filipe4 aut
2451 0a Size-Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice :b Toward Safe-by-Design
264 c 2020-05-07
264 1b Wiley,c 2020
338 a print2 rdacarrier
520 a Safety assessment of graphene-based materials (GBMs) including graphene oxide (GO) is essential for their safe use across many sectors of society. In particular, the link between specific material properties and biological effects needs to be further elucidated. Here, the effects of lateral dimensions of GO sheets in acute and chronic pulmonary responses after single intranasal instillation in mice are compared. Micrometer-sized GO induces stronger pulmonary inflammation than nanometer-sized GO, despite reduced translocation to the lungs. Genome-wide RNA sequencing also reveals distinct size-dependent effects of GO, in agreement with the histopathological results. Although large GO, but not the smallest GO, triggers the formation of granulomas that persists for up to 90 days, no pulmonary fibrosis is observed. These latter results can be partly explained by Raman imaging, which evidences the progressive biotransformation of GO into less graphitic structures. The findings demonstrate that lateral dimensions play a fundamental role in the pulmonary response to GO, and suggest that airborne exposure to micrometer-sized GO should be avoided in the production plant or applications, where aerosolized dispersions are likely to occur. These results are important toward the implementation of a safer-by-design approach for GBM products and applications, for the benefit of workers and end-users.
650 7a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng
650 7a NATURVETENSKAPx Fysik0 (SwePub)1032 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciences0 (SwePub)1032 hsv//eng
653 a graphene oxide
653 a inflammation
653 a lung
653 a macrophages
653 a mice
653 a RNA sequencing
7001 a Newman, Leon4 aut
7001 a Jasim, Dhifaf4 aut
7001 a Mukherjee, Sourav P.4 aut
7001 a Wang, Junu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)juwa8232
7001 a Vacchi, Isabella A.4 aut
7001 a Ménard-Moyon, Cécilia4 aut
7001 a Bianco, Alberto4 aut
7001 a Fadeel, Bengtu Karolinska Institutet4 aut
7001 a Kostarelos, Kostas4 aut
7001 a Bussy, Cyrill4 aut
7102 a Stockholms universitetb Institutionen för biokemi och biofysik4 org
7730 t Advanced Scienced : Wileyg 7:12q 7:12x 2198-3844
8564 u https://doi.org/10.1002/advs.201903200y Fulltext
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.201903200
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-181934
8564 8u https://doi.org/10.1002/advs.201903200
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143601386

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