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Sökning: WFRF:(Van Wendel De Joode Berna) > Prenatal current-us...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004879naa a2200433 4500
001oai:lup.lub.lu.se:8540f8ac-88e8-4c09-821a-17b4eac1dbab
003SwePub
008240312s2024 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/8540f8ac-88e8-4c09-821a-17b4eac1dbab2 URI
0247 a https://doi.org/10.1016/j.envres.2024.1182222 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Conejo-Bolaños, L. Diegou National University Of Costa Rica4 aut
2451 0a Prenatal current-use pesticide exposure and children's neurodevelopment at one year of age in the Infants' Environmental Health (ISA) birth cohort, Costa Rica
264 1c 2024
520 a Background: Pesticide exposure may affect young children's neurodevelopment, but only few cohort studies have addressed possible effects of non-organophosphate pesticides. Objective: We evaluated associations between prenatal current-use pesticide exposure and neurodevelopmental outcomes among 1-year-old children from the Infants’ Environmental Health (ISA) birth cohort. Methods: To determine prenatal pesticide exposure, we measured biomarkers of pyrimethanil, chlorpyrifos, synthetic pyrethroids, and 2,4-D in urine samples among 355 women, 1–3 times during pregnancy. One-year post-partum, we evaluated children's neurodevelopment with the Bayley Scales of Infant and Toddler Development 3rd edition (BSID-III). We assessed associations between exposures and neurodevelopmental outcomes (composite and z-scores) using single-chemical linear regression models adjusted for possible confounders (maternal education, parity, sex, gestational age at birth, child age, HOME-score, location of assessment, biomarkers of mancozeb), and studied effect-modification by sex. We evaluated non-linear associations of multiple pesticide exposures with Bayesian kernel machine regression (BKMR). Results: We found higher prenatal urinary 2,4-D concentrations were associated with lower language (βper ten-fold increase = −2.0, 95 % confidence interval (CI) = −3.5, −0.5) and motor (βper ten-fold increase = −2.2, 95 %CI = −4.2, −0.1) composite scores among all children. Also, higher chlorpyrifos exposure [measured as urinary 3,5,6-trichloro-2-pyridinol (TCPy)] was associated with lower cognitive composite scores (βper ten-fold increase = −1.9, 95 %CI = −4.7, 0.8), and lower motor composite scores among boys (βper ten-fold increase = −3.8, 95 % CI = −7.7, 0.1) but not girls (βper ten-fold increase = 2.3, 95 %CI = −1.6, 6.3, pINT = 0.11). Finally, higher pyrimethanil was associated with lower language abilities among girls, but not boys. Pyrethroid metabolite concentrations did not explain variability in BSID-III composite scores. Associations were similar for BSID-III z-scores, and we found no evidence for non-linear associations or mixture effects. Discussion: Prenatal exposure to common-use pesticides may affect children's neurodevelopment at 1-year of age, some effects may be sex-specific.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a 2,4-D
653 a Chlorpyrifos
653 a Epidemiology
653 a In-utero
653 a Pesticides
653 a Pyrimethanil
7001 a Mora, Ana M.u University of California, Berkeley,National University Of Costa Rica4 aut
7001 a Hernández-Bonilla, Davidu National Institute of Public Health, Mexico4 aut
7001 a Cano, Juan Camilou National University Of Costa Rica4 aut
7001 a Menezes-Filho, José A.u Federal University of Bahia4 aut
7001 a Eskenazi, Brendau University of California, Berkeley4 aut
7001 a Lindh, Christian H.u Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)ymed-cli
7001 a van Wendel de Joode, Bernau National University Of Costa Rica4 aut
7102 a National University Of Costa Ricab University of California, Berkeley4 org
7730 t Environmental Researchg 249q 249x 0013-9351
8564 u http://dx.doi.org/10.1016/j.envres.2024.118222x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/8540f8ac-88e8-4c09-821a-17b4eac1dbab
8564 8u https://doi.org/10.1016/j.envres.2024.118222

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