Letrozole increases ovarian growth and Cyp17a1 gene expression in the rat ovary

• Objective: To evaluate the effects of letrozole on ovarian size and steroidogenesis in vivo, as well as Design: In vivo and in vitro studies. Setting: Research laboratory. Animal(s): Immature Sprague-Dawley female rats. Intervention(s): In vivo effects of letrozole were studied in intact rats receiving either letrozole (90-day Main Outcome Measure(s): Deoxyribonucleic acid synthesis was determined by thymidine Result(s): In vivo, letrozole induced an increase in ovarian size compared with the control group and Conclusion(s): These findings suggest that letrozole exerts potent, but indirect, effect on growth of rat

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

CYP17A1

letrozole

ovarian theca-interstitial cells

proliferation

steroidogenesis

theca-interstitial cells

induced polycystic ovaries

acute regulatory

protein

advanced breast-cancer

aromatase inhibitors

luteinizing-hormone

clomiphene citrate

androgen receptor

transgenic

mice

messenger-rna

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