A molecular mechanism explaining albuminuria in kidney disease

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Fältnamn	Indikatorer	Metadata
000		06667naa a2200613 4500
001		oai:DiVA.org:kth-276659
003		SwePub
008		200622s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:145291846
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2766592 URI
024	7	a https://doi.org/10.1038/s42255-020-0204-y2 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1452918462 URI
040		a (SwePub)kthd (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Butt, Linusu Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
245	1 0	a A molecular mechanism explaining albuminuria in kidney disease
264		c 2020-05-11
264	1	b Springer Nature,c 2020
338		a print2 rdacarrier
500		a QC 20200622
520		a Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal filtration barrier results in loss of albumin into urine (albuminuria) across the wall of small renal capillaries, and is a leading cause of chronic kidney disease. However, exactly how the renal filter works and why its permeability is altered in kidney diseases is poorly understood. Here we show that the permeability of the renal filter is modulated through compression of the capillary wall. We collect morphometric data prior to and after onset of albuminuria in a mouse model equivalent to a human genetic disease affecting the renal filtration barrier. Combining quantitative analyses with mathematical modelling, we demonstrate that morphological alterations of the glomerular filtration barrier lead to reduced compressive forces that counteract filtration pressure, thereby resulting in capillary dilatation, and ultimately albuminuria. Our results reveal distinct functions of the different layers of the filtration barrier and expand the molecular understanding of defective renal filtration in chronic kidney disease.
650	7	a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng
700	1	a Jess, David Unnersjöu KTH,Biofysik,Science for Life Laboratory, SciLifeLab,Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut0 (Swepub:kth)u10c8quf
700	1	a Hohne, Martinu Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
700	1	a Edwards, Aurelieu Boston Univ, Dept Biomed Engn, Boston, MA USA.4 aut
700	1	a Binz-Lotter, Juliau Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
700	1	a Reilly, Dervlau Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
700	1	a Hahnfeldt, Robertu Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
700	1	a Ziegler, Verau Univ Regensburg, Inst Physiol, Regensburg, Germany.4 aut
700	1	a Fremter, Katharinau Univ Regensburg, Inst Physiol, Regensburg, Germany.4 aut
700	1	a Rinschen, Markus M.u Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Scripps Res Inst, Ctr Mass Spectrometry & Metabol, La Jolla, CA USA.4 aut
700	1	a Helmstaedter, Martinu Univ Freiburg, Dept Med 4, Fac Med, Med Ctr, Freiburg, Germany.;Univ Freiburg, Signalling Res Ctr BIOSS & CIBSS, Freiburg, Germany.4 aut
700	1	a Ebert, Lena K.u Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
700	1	a Castrop, Hayou Univ Regensburg, Inst Physiol, Regensburg, Germany.4 aut
700	1	a Hackl, Matthias J.u Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
700	1	a Walz, Gerdu Univ Freiburg, Dept Med 4, Fac Med, Med Ctr, Freiburg, Germany.;Univ Freiburg, Signalling Res Ctr BIOSS & CIBSS, Freiburg, Germany.4 aut
700	1	a Brinkkoetter, Paul T.u Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.4 aut
700	1	a Liebau, Max C.u Univ Cologne, Fac Med, Dept Pediat, Cologne, Germany.;Univ Cologne, Ctr Mol Med, Fac Med, Cologne, Germany.4 aut
700	1	a Tory, Kalmanu Semmelweis Univ, Dept Pediat 1, MTA SE Lendulet Nephrogenet Lab, Budapest, Hungary.4 aut
700	1	a Hoyer, Peter F.u Univ Duisburg Essen, Univ Childrens Hosp, Clin Pediat 2, Essen, Germany.4 aut
700	1	a Beck, Bodo B.u Univ Cologne, Inst Human Genet, Fac Med, Cologne, Germany.4 aut
700	1	a Brismar, Hjalmaru Karolinska Institutet,KTH,Biofysik4 aut0 (Swepub:kth)u1232ew5
700	1	a Blom, Hans,d 1968-u KTH,Biofysik4 aut0 (Swepub:kth)u1qhk3ta
700	1	a Schermer, Bernhardu Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, CECAD, Cologne, Germany.4 aut
700	1	a Benzing, Thomasu Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, CECAD, Cologne, Germany.4 aut
710	2	a Univ Cologne, Dept Internal Med 2, Fac Med, Cologne, Germany.;Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.;Univ Hosp Cologne, Cologne, Germany.b Biofysik4 org
773	0	t Nature Metabolismd : Springer Natureg 2:5, s. 461-474q 2:5<461-474x 2522-5812
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-276659
856	4 8	u https://doi.org/10.1038/s42255-020-0204-y
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145291846

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