Sökning: WFRF:(Wendl Michael) > Initial sequence of...
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000 | 08380naa a2201129 4500 | |
001 | oai:DiVA.org:uu-108258 | |
003 | SwePub | |
008 | 090910s2005 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1082582 URI |
024 | 7 | a https://doi.org/10.1038/nature040722 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mikkelsen, Tarjeiu Broad Institute4 aut |
245 | 1 0 | a Initial sequence of the chimpanzee genome and comparison with the human genome |
264 | 1 | b Springer Science and Business Media LLC,c 2005 |
338 | a print2 rdacarrier | |
520 | a Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution. | |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
653 | a Genetics | |
653 | a Genetik | |
653 | a Genetics | |
653 | a Genetik | |
700 | 1 | a Hillier, LaDeanau Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Eichler, Evanu University of Washington, Department of Genome Sciences4 aut |
700 | 1 | a Zody, Michael,d 1968-u Broad Institute4 aut0 (Swepub:uu)miczo266 |
700 | 1 | a Jaffe, Davidu Broad Institute4 aut |
700 | 1 | a Yang, Shiaw-Pyngu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Enard, Wolfgangu Max Planck Institute of Evolutionary Anthropology4 aut |
700 | 1 | a Hellmann, Inesu Max Planck Institute of Evolutionary Anthropology4 aut |
700 | 1 | a Lindblad-Toh, Kerstinu Broad Institute4 aut |
700 | 1 | a Altheide, Tashau University of California, San Diego4 aut |
700 | 1 | a Archidiacono, Nicolettau University of Bari, Department of Genetics and Microbiology4 aut |
700 | 1 | a Bork, Peeru EMBL4 aut |
700 | 1 | a Butler, Jonathanu Broad Institute4 aut |
700 | 1 | a Chang, Jeanu Broad Institute4 aut |
700 | 1 | a Cheng, Zeu University of Washington, Department of Genome Sciences4 aut |
700 | 1 | a Chinwalla, Asifu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a de Jong, Pieteru Children's Hospital Oakland Research Institute4 aut |
700 | 1 | a Delehaunty, Kimberleyu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Fronick, Catrinau Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Fulton, Lucindau Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Gilad, Yoavu Yale University School of Medicine, Department of Genetics4 aut |
700 | 1 | a Glusman, Gustavou Institute for Systems Biology4 aut |
700 | 1 | a Gnerre, Santeu Broad Institute4 aut |
700 | 1 | a Graves, Tinau Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Hayakawa, Toshiyukiu University of California, San Diego4 aut |
700 | 1 | a Hayden, Karenu Case Western Reserve University, Department of Genetics4 aut |
700 | 1 | a Huang, Xiaoqiuu Iowa State University, Department of Computer Science4 aut |
700 | 1 | a Ji, Hongkaiu Harvard University, Department of Statistics4 aut |
700 | 1 | a Kent, W.u University of California, Santa Cruz, Center for Biomolecular Science and Engineering4 aut |
700 | 1 | a King, Mary-Claireu University of Washington, Department of Genome Sciences4 aut |
700 | 1 | a Kulbokas, Edwardu Broad Institute4 aut |
700 | 1 | a Lee, Mingu University of Washington, Department of Genome Sciences4 aut |
700 | 1 | a Liu, Geu Case Western Reserve University, Department of Genetics4 aut |
700 | 1 | a Lopez-Otin, Carlosu Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Departamento de Bioquimica y Biologia Molecular4 aut |
700 | 1 | a Makova, Katerynau The Pennsylvania State University, Center for Comparative Genomics and Bioinformatics and Department of Biology4 aut |
700 | 1 | a Man, Ornau Weizmann Institute of Science, Department of Structural Biology4 aut |
700 | 1 | a Mardis, Elaineu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Mauceli, Evanu Broad Institute4 aut |
700 | 1 | a Miner, Tracieu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Nash, illiamu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Nelson, Joanneu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Pääbo, Svanteu Max Planck Institute of Evolutionary Anthropology4 aut |
700 | 1 | a Patterson, Nicku Broad Institute4 aut |
700 | 1 | a Pohl, Craigu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Pollard, Katherineu University of California, Santa Cruz, Center for Biomolecular Science and Engineering4 aut |
700 | 1 | a Prüfer, Kayu Max Planck Institute for Evolutionary Anthropology4 aut |
700 | 1 | a Puente, Xoseu Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Departamento de Bioquimica y Biologia Molecular4 aut |
700 | 1 | a Reich, Davidu Broad Institute4 aut |
700 | 1 | a Rocchi, Marianou University of Bari, Department of Genetics and Microbiology4 aut |
700 | 1 | a Rosenbloom, Kateu University of California, Santa Cruz, Center for Biomolecular Science and Engineering4 aut |
700 | 1 | a Ruvolo, Maryellenu Harvard University, Department of Anthropology and of Organismic and Evolutionary Biology4 aut |
700 | 1 | a Richter, Danielu Broad Institute4 aut |
700 | 1 | a Schaffner, Stephenu Broad Institute4 aut |
700 | 1 | a Smit, Arianu Institute for Systems Biology4 aut |
700 | 1 | a Smith, Scottu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Suyama, Mikitau EMBL4 aut |
700 | 1 | a Taylor, Jamesu The Pennsylvania State University, Center for Comparative Genomics and Bioinformatics and Department of Biology4 aut |
700 | 1 | a Torrents, Davidu EMBL4 aut |
700 | 1 | a Tuzun, Erayu University of Washington, Department of Genome Sciences4 aut |
700 | 1 | a Varki, Ajitu University of California, San Diego4 aut |
700 | 1 | a Velasco, Gloriau Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Departamento de Bioquimica y Biologia Molecular4 aut |
700 | 1 | a Ventura, Mariou University of Bari, Department of Genetics and Microbiology4 aut |
700 | 1 | a Wallis, Johnu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Wendl, Michaelu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Wilson, Richardu Washington University School of Medicine, Genome Sequencing Center4 aut |
700 | 1 | a Lander, Ericu Broad Institute4 aut |
700 | 1 | a Waterston, Robertu University of Washington, Department of Genome Sciences4 aut |
710 | 2 | a Broad Instituteb Washington University School of Medicine, Genome Sequencing Center4 org |
773 | 0 | t Natured : Springer Science and Business Media LLCg 437:7055, s. 69-87q 437:7055<69-87x 0028-0836x 1476-4687 |
856 | 4 | u https://www.nature.com/articles/nature04072.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108258 |
856 | 4 8 | u https://doi.org/10.1038/nature04072 |
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