Sökning: WFRF:(Whincup Peter) > (2020-2023) > Evaluating an Inter...
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000 | 04792naa a2200529 4500 | |
001 | oai:research.chalmers.se:90cb3866-834e-48c0-b13d-56a57c9a31bb | |
003 | SwePub | |
008 | 210414s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://research.chalmers.se/publication/5232932 URI |
024 | 7 | a https://doi.org/10.1093/jn/nxaa3472 DOI |
040 | a (SwePub)cth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Donin, Angela S.u University of London4 aut |
245 | 1 0 | a Evaluating an Intervention to Increase Cereal Fiber Intake in Children: A Randomized Controlled Feasibility Trial |
264 | 1 | b Elsevier BV,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: Observational studies have shown that higher cereal fiber intake is associated with reduced type 2 diabetes risk. However, it remains uncertain whether this association is causal. OBJECTIVE: This study evaluated the feasibility of an intervention to increase cereal fiber intake in children using breakfast cereals. METHODS: The study was a 2-arm parallel group randomized controlled trial in 9-10-y-old children, who received free supplies of high-fiber breakfast cereals (>3.5 g/portion) or low-fiber breakfast cereals (<1.0 g/portion) to eat daily for 1 mo with behavioral support to promote adherence. Children provided baseline and 1-mo fasting blood samples, physical measurements, and 24-h dietary recalls. The primary outcome was the group difference in change in plasma total alkylresorcinol (AR) concentration; secondary outcomes were group differences in nutrient intakes and adiposity indices. Analyses (complete case and multiple imputation) were conducted by regressing the final AR concentration on baseline AR in models adjusted for sex, ethnicity, age, and school (random effect). RESULTS: Two-hundred seventy-two children were randomly assigned (137 receiving a low-fiber and 135 a high-fiber diet) and 193 (71%) provided fasting blood samples at baseline and follow-up. Among randomized participants, median (IQR) of baseline AR was 43.1 (24.6-85.5) nmol/L and of cereal fiber intake was 4.5 (2.7-6.4) g; 87% of participants reported consuming the cereal on most or all days. Compared with changes in the low-fiber group, the high-fiber group had greater increases in AR (40.7 nmol/L; 95% CI: 21.7, 59.8 nmol/L, P < 0.0001) and in reported cereal fiber intake (2.9g/d; 95% CI: 2.0, 3.7 g; P < 0.0001). There were no appreciable differences in other secondary outcomes. CONCLUSIONS: We have developed a simple and acceptable nutritional intervention that increases markers of daily cereal fiber intake in children. This intervention could be used to test whether increases in cereal fiber intake in children might reduce insulin resistance. This trial was registered at www.isrctn.com as ISRCTN33260236. | |
650 | 7 | a LANTBRUKSVETENSKAPERx Lantbruksvetenskap, skogsbruk och fiskex Livsmedelsvetenskap0 (SwePub)401032 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Agriculture, Forestry and Fisheriesx Food Science0 (SwePub)401032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
653 | a children | |
653 | a type 2 diabetes risk | |
653 | a Cereal fiber | |
653 | a feasibility trial | |
653 | a dietary intervention | |
700 | 1 | a Nightingale, Claire M.u University of London4 aut |
700 | 1 | a Perkin, Michael R.u University of London4 aut |
700 | 1 | a Ussher, Michaelu University of Stirling,University of London4 aut |
700 | 1 | a Jebb, Susan A.u University Of Oxford4 aut |
700 | 1 | a Landberg, Rikard,d 1981u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)riklan |
700 | 1 | a Welsh, Paulu University of Glasgow4 aut |
700 | 1 | a Sattar, Naveedu University of Glasgow4 aut |
700 | 1 | a Adab, Peymaneu University of Birmingham4 aut |
700 | 1 | a Owen, Chris G.u University of London4 aut |
700 | 1 | a Rudnicka, Alicja R.u University of London4 aut |
700 | 1 | a Cook, Derek G.u University of London4 aut |
700 | 1 | a Whincup, Peter H.u University of London4 aut |
710 | 2 | a University of Londonb University of Stirling4 org |
773 | 0 | t Journal of Nutritiond : Elsevier BVg 151:2, s. 379-386q 151:2<379-386x 1541-6100x 0022-3166 |
856 | 4 | u https://research.chalmers.se/publication/523293/file/523293_Fulltext.pdfx primaryx freey FULLTEXT |
856 | 4 | u https://academic.oup.com/jn/article-pdf/151/2/379/36154469/nxaa347.pdf |
856 | 4 8 | u https://research.chalmers.se/publication/523293 |
856 | 4 8 | u https://doi.org/10.1093/jn/nxaa347 |
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