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  • Cizmeci, Mehmet NUniversity of Toronto (författare)

Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation : Outcome at 2 Years

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:c32c7b66-4c20-4844-bede-a7f3fa848608
  • https://lup.lub.lu.se/record/c32c7b66-4c20-4844-bede-a7f3fa848608URI
  • https://doi.org/10.1016/j.jpeds.2020.08.014DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE: To compare the effect of intervention at low vs high threshold of ventriculomegaly in preterm infants with posthemorrhagic ventricular dilatation on death or severe neurodevelopmental disability.STUDY DESIGN: This multicenter randomized controlled trial reviewed lumbar punctures initiated after either a low threshold (ventricular index of >p97 and anterior horn width of >6 mm) or high threshold (ventricular index of >p97 + 4 mm and anterior horn width of >10 mm). The composite adverse outcome was defined as death or cerebral palsy or Bayley composite cognitive/motor scores <-2 SDs at 24 months corrected age.RESULTS: Outcomes were assessed in 113 of 126 infants. The composite adverse outcome was seen in 20 of 58 infants (35%) in the low threshold group and 28 of 55 (51%) in the high threshold (P = .07). The low threshold intervention was associated with a decreased risk of an adverse outcome after correcting for gestational age, severity of intraventricular hemorrhage, and cerebellar hemorrhage (aOR, 0.24; 95% CI, 0.07-0.87; P = .03). Infants with a favorable outcome had a smaller fronto-occipital horn ratio (crude mean difference, -0.06; 95% CI, -0.09 to -0.03; P < .001) at term-equivalent age. Infants in the low threshold group with a ventriculoperitoneal shunt, had cognitive and motor scores similar to those without (P = .3 for both), whereas in the high threshold group those with a ventriculoperitoneal shunt had significantly lower scores than those without a ventriculoperitoneal shunt (P = .01 and P = .004, respectively).CONCLUSIONS: In a post hoc analysis, earlier intervention was associated with a lower odds of death or severe neurodevelopmental disability in preterm infants with progressive posthemorrhagic ventricular dilatation.TRIAL REGISTRATION: ISRCTN43171322.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Groenendaal, FlorisErasmus University Medical Center (författare)
  • Liem, Kian DRadboud University Medical Center (författare)
  • van Haastert, Ingrid CErasmus University Medical Center (författare)
  • Benavente-Fernández, IsabelPuerta del Mar University Hospital (författare)
  • van Straaten, Henrica L MIsala Women and Children's Hospital (författare)
  • Steggerda, SylkeLeiden University Medical Centre (författare)
  • Smit, Bert JErasmus University Medical Center (författare)
  • Whitelaw, AndrewUniversity of Bristol (författare)
  • Woerdeman, PeterUniversity Medical Center Utrecht (författare)
  • Heep, AxelUniversity of Bristol (författare)
  • de Vries, Linda SErasmus University Medical Center (författare)
  • Ley, DavidLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups(Swepub:lu)pedi-dle (creator_code:cre_t)
  • Fellman, VinetaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pedi-vfe (creator_code:cre_t)
  • University of TorontoErasmus University Medical Center (creator_code:org_t)
  • ELVIS study group

Sammanhörande titlar

  • Ingår i:Journal of Pediatrics: Elsevier BV226, s. 3-351097-68330022-3476

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