WFRF:(Wilmes S)
Sökning: WFRF:(Wilmes S) > (2015-2019) > Birth mode is assoc...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05538naa a2201417 4500 | |
| 001 | oai:DiVA.org:kth-247015 | |
| 003 | SwePub | |
| 008 | 190626s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2470152 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-018-07631-x2 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wampach, L.4 aut |
| 245 | 1 0 | a Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential |
| 264 | c 2018-11-30 | |
| 264 | 1 | b Nature Publishing Group,c 2018 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20190626 | |
| 520 | a The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and whether it affects human physiology. Here we perform metagenomic analysis of earliest gut microbial community structures and functions. We identify differences in encoded functions between microbiomes of vaginally delivered (VD) and CSD neonates. Several functional pathways are over-represented in VD neonates, including lipopolysaccharide (LPS) biosynthesis. We link these enriched functions to individual-specific strains, which are transmitted from mothers to neonates in case of VD. The stimulation of primary human immune cells with LPS isolated from early stool samples of VD neonates results in higher levels of tumour necrosis factor (TNF-α) and interleukin 18 (IL-18). Accordingly, the observed levels of TNF-α and IL-18 in neonatal blood plasma are higher after VD. Taken together, our results support that CSD disrupts mother-to-neonate transmission of specific microbial strains, linked functional repertoires and immune-stimulatory potential during a critical window for neonatal immune system priming. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
| 653 | a beta interferon | |
| 653 | a galectin 1 | |
| 653 | a gamma interferon | |
| 653 | a granzyme B | |
| 653 | a interleukin 10 | |
| 653 | a interleukin 12 | |
| 653 | a interleukin 13 | |
| 653 | a interleukin 15 | |
| 653 | a interleukin 18 | |
| 653 | a interleukin 1beta | |
| 653 | a interleukin 2 | |
| 653 | a interleukin 21 | |
| 653 | a interleukin 23 | |
| 653 | a interleukin 23p40 | |
| 653 | a interleukin 27 | |
| 653 | a interleukin 4 | |
| 653 | a interleukin 5 | |
| 653 | a interleukin 6 | |
| 653 | a interleukin 8 | |
| 653 | a RNA 16S | |
| 653 | a tumor necrosis factor | |
| 653 | a unclassified drug | |
| 653 | a interleukin 18 protein | |
| 653 | a human | |
| 653 | a lipopolysaccharide | |
| 653 | a cell | |
| 653 | a community structure | |
| 653 | a digestive system | |
| 653 | a genetic analysis | |
| 653 | a immune system | |
| 653 | a microbial community | |
| 653 | a microorganism | |
| 653 | a neonate | |
| 653 | a physiology | |
| 653 | a amplicon | |
| 653 | a Article | |
| 653 | a bacterial strain | |
| 653 | a cesarean section | |
| 653 | a DNA sequence | |
| 653 | a female | |
| 653 | a gene function | |
| 653 | a genetic variability | |
| 653 | a human | |
| 653 | a human cell | |
| 653 | a human tissue | |
| 653 | a immunostimulation | |
| 653 | a intestine flora | |
| 653 | a marker gene | |
| 653 | a metagenomics | |
| 653 | a microbial colonization | |
| 653 | a newborn | |
| 653 | a quantitative analysis | |
| 653 | a real time polymerase chain reaction | |
| 653 | a sequence homology | |
| 653 | a taxonomy | |
| 653 | a vagina flora | |
| 653 | a vaginal delivery | |
| 653 | a genetics | |
| 653 | a in vitro study | |
| 653 | a metabolism | |
| 653 | a obstetric delivery | |
| 653 | a pregnancy | |
| 653 | a procedures | |
| 653 | a vertical transmission | |
| 653 | a Delivery | |
| 653 | a Obstetric | |
| 653 | a Gastrointestinal Microbiome | |
| 653 | a Humans | |
| 653 | a In Vitro Techniques | |
| 653 | a Infant | |
| 653 | a Newborn | |
| 653 | a Infectious Disease Transmission | |
| 653 | a Vertical | |
| 653 | a Interleukin-18 | |
| 653 | a Lipopolysaccharides | |
| 653 | a Tumor Necrosis Factor-alpha | |
| 700 | 1 | a Heintz-Buschart, A.4 aut |
| 700 | 1 | a Fritz, J. V.4 aut |
| 700 | 1 | a Ramiro-Garcia, J.4 aut |
| 700 | 1 | a Habier, J.4 aut |
| 700 | 1 | a Herold, M.4 aut |
| 700 | 1 | a Narayanasamy, S.4 aut |
| 700 | 1 | a Kaysen, A.4 aut |
| 700 | 1 | a Hogan, A. H.4 aut |
| 700 | 1 | a Bindl, L.4 aut |
| 700 | 1 | a Bottu, J.4 aut |
| 700 | 1 | a Halder, R.4 aut |
| 700 | 1 | a Sjöqvist, Connyu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u19ca8zu |
| 700 | 1 | a May, P.4 aut |
| 700 | 1 | a Andersson, Anders F.u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1hi776x |
| 700 | 1 | a de Beaufort, C.4 aut |
| 700 | 1 | a Wilmes, P.4 aut |
| 710 | 2 | a KTHb Science for Life Laboratory, SciLifeLab4 org |
| 773 | 0 | t Nature Communicationsd : Nature Publishing Groupg 9:1q 9:1x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-018-07631-x.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-247015 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-018-07631-x |
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