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Sökning: WFRF:(Xue Shanyan) > (2010) > Population-Based St...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004200naa a2200493 4500
001oai:lup.lub.lu.se:67190f37-9d28-4232-9d9f-4966a35d83cd
003SwePub
008160404s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/15955682 URI
0247 a https://doi.org/10.1200/JCO.2009.24.24952 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Malone, Kathleen E4 aut
2451 0a Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation in BRCA1 or BRCA2.
264 1c 2010
520 a PURPOSE: Women with breast cancer diagnosed early in life comprise a substantial portion of those tested for BRCA1/BRCA2 mutations; however, little information is available on the subsequent risks of contralateral breast cancer in mutation carriers. This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation. PATIENTS AND METHODS: In this nested case-control study, patients with contralateral breast cancer diagnosed 1 year or more after a first primary breast cancer (n = 705) and controls with unilateral breast cancer (n = 1,398) were ascertained from an underlying population-based cohort of 52,536 women diagnosed with a first invasive breast cancer before age 55 years. Interviews and medical record reviews were used to collect risk factor and treatment histories. All women were tested for BRCA1/BRCA2 mutations. Relative (rate ratios) and absolute (5- and 10-year cumulative) risks of developing contralateral breast cancer following a first invasive breast cancer were computed. RESULTS: Compared with noncarriers, BRCA1 and BRCA2 mutation carriers had 4.5-fold (95% CI, 2.8- to 7.1-fold) and 3.4-fold (95% CI, 2.0- to 5.8-fold) increased risks of contralateral breast cancer, respectively. The relative risk of contralateral breast cancer for BRCA1 mutation carriers increased as age of first diagnosis decreased. Age-specific cumulative risks are provided for clinical guidance. CONCLUSION: The risks of subsequent contralateral breast cancer are substantial for women who carry a BRCA1/BRCA2 mutation. These findings have important clinical relevance regarding the assessment of BRCA1/BRCA2 status in patients with breast cancer and the counseling and clinical management of patients found to carry a mutation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Begg, Colin B4 aut
7001 a Haile, Robert W4 aut
7001 a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
7001 a Concannon, Patrick4 aut
7001 a Tellhed, Linau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-ljo
7001 a Xue, Shanyan4 aut
7001 a Teraoka, Sharon4 aut
7001 a Bernstein, Leslie4 aut
7001 a Capanu, Marinela4 aut
7001 a Reiner, Anne S4 aut
7001 a Riedel, Elyn R4 aut
7001 a Thomas, Duncan C4 aut
7001 a Mellemkjær, Lene4 aut
7001 a Lynch, Charles F4 aut
7001 a Boice, John D4 aut
7001 a Anton-Culver, Hoda4 aut
7001 a Bernstein, Jonine L4 aut
7102 a Bröstcancer-genetikb Sektion I4 org
7730 t Journal of Clinical Oncologyg 28, s. 2404-2410q 28<2404-2410x 1527-7755
8564 u http://www.ncbi.nlm.nih.gov/pubmed/20368571?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1200/JCO.2009.24.2495y FULLTEXT
8564 8u https://lup.lub.lu.se/record/1595568
8564 8u https://doi.org/10.1200/JCO.2009.24.2495

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