Oral Polio Vaccine Influences the Immune Response to BCG Vaccination. A Natural Experiment

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Fältnamn	Indikatorer	Metadata
000		03878naa a2200445 4500
001		oai:lup.lub.lu.se:99c9da63-4979-43ad-8703-6122634f7966
003		SwePub
008		160401s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/16166412 URI
024	7	a https://doi.org/10.1371/journal.pone.00103282 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Sartono, Erliyani4 aut
245	1 0	a Oral Polio Vaccine Influences the Immune Response to BCG Vaccination. A Natural Experiment
264		c 2010-05-21
264	1	b Public Library of Science (PLoS),c 2010
338		a electronic2 rdacarrier
520		a Background: Oral polio vaccine (OPV) is recommended to be given at birth together with BCG vaccine. While we were conducting two trials including low-birth-weight (LBW) and normal-birth-weight (NBW) infants in Guinea-Bissau, OPV was not available during some periods and therefore some infants did not receive OPV at birth, but only BCG. We investigated the effect of OPV given simultaneously with BCG at birth on the immune response to BCG vaccine. Methods and Findings: We compared the in vitro and the in vivo response to PPD in the infants who received OPV and BCG with that of infants who received BCG only. At age 6 weeks, the in vitro cytokine response to purified protein derivate (PPD) of M. Tuberculosis was reduced in LBW and NBW infants who had received OPV with BCG. In a pooled analysis receiving OPV with BCG at birth was associated with significantly lower IL-13 (p = 0.041) and IFN-gamma (p = 0.004) and a tendency for lower IL-10 (p = 0.054) in response to PPD. Furthermore, OPV was associated with reduced in vivo response to PPD at age 2 months, the prevalence ratio (PR) of having a PPD reaction being 0.75 (0.58-0.98), p = 0.033, and with a tendency for reduced likelihood of having a BCG scar (0.95 (0.91-1.00), p = 0.057)). Among children with a scar, OPV was associated with reduced scar size, the regression coefficient being -0.24 (-0.43-0.05), p = 0.012. Conclusions: This study is the first to address the consequences for the immune response to BCG of simultaneous administration with OPV. Worryingly, the results indicate that the common practice in low-income countries of administering OPV together with BCG at birth may down-regulate the response to BCG vaccine.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
700	1	a Lisse, Ida M.4 aut
700	1	a Terveer, Elisabeth M.4 aut
700	1	a van de Sande, Paula J. M.4 aut
700	1	a Whittle, Hilton4 aut
700	1	a Fisker, Ane B.4 aut
700	1	a Roth, Adamu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-amr
700	1	a Aaby, Peter4 aut
700	1	a Yazdanbakhsh, Maria4 aut
700	1	a Benn, Christine S.4 aut
710	2	a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org
773	0	t PLoS ONEd : Public Library of Science (PLoS)g 5:5q 5:5x 1932-6203
856	4	u https://portal.research.lu.se/files/3507756/1627972.pdfx primaryx freey FULLTEXT
856	4	u http://www.ncbi.nlm.nih.gov/sites/pubmedx freey FULLTEXT
856	4	u http://dx.doi.org/10.1371/journal.pone.0010328x freey FULLTEXT
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010328&type=printable
856	4 8	u https://lup.lub.lu.se/record/1616641
856	4 8	u https://doi.org/10.1371/journal.pone.0010328

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