The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years

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Fältnamn	Indikatorer	Metadata
000		05539naa a2200577 4500
001		oai:DiVA.org:liu-202497
003		SwePub
008		240415s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2024972 URI
024	7	a https://doi.org/10.1186/s13613-024-01246-w2 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a de Lange, Dylan W.u Univ Utrecht, Netherlands4 aut
245	1 0	a The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years
264	1	b SPRINGER,c 2024
338		a print2 rdacarrier
500		a Funding Agencies\|DRC Ile de France; URC Est helped conducting VIP2 in France
520		a Background Premorbid conditions influence the outcome of acutely ill adult patients aged 80 years and over who are admitted to the ICU. The aim of this study was to determine the influence of such premorbid conditions on 6 month survival. Methods Prospective cohort study in 242 ICUs from 22 countries including patients 80 years or above, admitted over a 6 months period to an ICU between May 2018 and May 2019. Only emergency (acute) ICU admissions in adult patients >= 80 years of age were eligible. Patients who were admitted after planned/elective surgery were excluded. We measured the Clinical Frailty Scale (CFS), the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), disability with the Katz activities of daily living (ADL) score, comorbidities and a Polypharmacy Score (CPS). Results Overall, the VIP2 study included 3920 patients. During ICU stay 1191 patients died (30.9%), and another 436 patients (11.1%) died after ICU discharge but within the first 30 days of admission, and an additional 895 patients died hereafter but within the first 6 months after admission (22.8%). The 6 months mortality was 64%. The median CFS was 4 (IQR 3-6). Frailty (CFS >= 5) was present in 26.6%. Cognitive decline (IQCODE above 3.5) was found in 30.2%. The median IQCODE was 3.19. A Katz ADL of 4 or less was present in 27.7%. Patients who surviving > 6 months were slightly younger (median age survivors 84 with IQR 81-86) than patients dying within the first 6 months (median age 84, IQR 82-87, p = 0.013), were less frequently frail (CFS > 5 in 19% versus 34%, p < 0.01) and were less dependent based on their Katz activities of daily living measurement (median Katz score 6, IQR 5-6 versus 6 points, IQR 3-6, p < 0.01). Conclusions We found that Clinical Frailty Scale, age, and SOFA at admission were independent prognostic factors for 6 month mortality after ICU admission in patients age 80 and above. Adding other geriatric syndromes and scores did not improve the model. This information can be used in shared-decision making. ClinicalTrials.gov: NCT03370692. Conclusions We found that Clinical Frailty Scale, age, and SOFA at admission were independent prognostic factors for 6 month mortality after ICU admission in patients age 80 and above. Adding other geriatric syndromes and scores did not improve the model. This information can be used in shared-decision making.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653		a Critical care; Outcome; Frailty; Cognitive functioning; Activities of daily living; Comorbidity
700	1	a Soliman, Ivo W.u Univ Utrecht, Netherlands4 aut
700	1	a Leaver, Susannahu St George Hosp, England4 aut
700	1	a Boumendil, Arianeu Hop St Antoine, France4 aut
700	1	a Haas, Lenneke E. M.u Diakonessen Hosp, Netherlands4 aut
700	1	a Watson, Ximenau St George Hosp, England4 aut
700	1	a Boulanger, Carolu Royal Devon & Exeter NHS Fdn Trust, England4 aut
700	1	a Szczeklik, Wojciechu Jagiellonian Univ Med Coll, Poland4 aut
700	1	a Artigas, Antoniou Autonomous Univ Barcelona, Spain; Sagrado Corazon Gen Cataluna Univ Hosp, Spain4 aut
700	1	a Morandi, Alessandrou Hosp Ancelle Cremona, Italy; Geriatr Res Grp, Italy4 aut
700	1	a Andersen, Finnu Alesund Hosp, Norway; NTNU, Norway4 aut
700	1	a Jung, Christianu Univ Hosp Dusseldorf, Germany4 aut
700	1	a Moreno, Ruiu Ctr Hosp Univ Lisboa Cent, Portugal; Univ Beira Interior, Portugal4 aut
700	1	a Walther, Sten M.,d 1954-u Region Östergötland, Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)stewa50
700	1	a Oeyen, Sandrau Ghent Univ Hosp, Belgium4 aut
700	1	a Schefold, Joerg C.u Univ Bern, Switzerland4 aut
700	1	a Cecconi, Mauriziou IRCCS, Italy; Humanitas Univ, Italy4 aut
700	1	a Marsh, Brianu Mater Misericordiae Univ Hosp, Ireland4 aut
700	1	a Joannidis, Michaelu Med Univ Innsbruck, Austria4 aut
700	1	a Nalapko, Yuriyu ICU, Ukraine4 aut
700	1	a Elhadi, Muhammedu ICU, Alkhums Hosp, Libya4 aut
700	1	a Fjolner, Jesperu Viborg Reg Hosp, Denmark4 aut
700	1	a Guidet, Bertrandu Hop St Antoine, France4 aut
700	1	a Flaatten, Hansu Univ Bergen, Norway4 aut
710	2	a Univ Utrecht, Netherlandsb St George Hosp, England4 org
773	0	t Annals of Intensive Cared : SPRINGERg 14:1q 14:1x 2110-5820
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202497
856	4 8	u https://doi.org/10.1186/s13613-024-01246-w

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