Sökning: WFRF:(van de Velde C. J. H.)
> (2010-2014) >
The prognostic role...
The prognostic role of TGF-β signaling pathway in breast cancer patients
-
- de Kruijf, E M (författare)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
-
- Dekker, T J A (författare)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
-
- Hawinkels, L J A C (författare)
- Departments of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
-
visa fler...
-
- Putter, H (författare)
- Departments of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
-
- Smit, V T H B M (författare)
- Departments of Pathology, Leiden University Medical Center, Leiden, The Netherlands
-
- Kroep, J R (författare)
- Departments of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands
-
- Kuppen, P J K (författare)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
-
- van de Velde, C J H (författare)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
-
- ten Dijke, Peter (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
-
- Tollenaar, R A E M (författare)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
-
- Mesker, W E (författare)
- Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
-
Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 24:2, s. 384-390
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BackgroundThe transforming growth factor-β (TGF-β) pathway has dual effects on tumor growth. Seemingly, discordant results have been published on the relation between TGF-β signaling markers and prognosis in breast cancer. Improved prognostic information for breast cancer patients might be obtained by assessing interactions among TGF-β signaling biomarkers.Patients and methodsThe expression of nuclear Smad4, nuclear phosphorylated-Smad2 (p-Smad2), and the membranous expression of TGF-β receptors I and II (TβRI and TβRII) was determined on a tissue microarray of 574 breast carcinomas. Tumors were stratified according to the Smad4 expression in combination with p-Smad2 expression or Smad4 in combination with the expression of both TGF-β receptors.ResultsTumors with high expression of TβRII, TβRI and TβRII, and p-Smad2 (P = 0.018, 0.005, and 0.022, respectively), and low expression of Smad4 (P = 0.005) had an unfavorable prognosis concerning progression-free survival. Low Smad4 expression combined with high p-Smad2 expression or low expression of Smad4 combined with high expression of both TGF-β receptors displayed an increased hazard ratio of 3.04 [95% confidence interval (CI) 1.390-6.658] and 2.20 (95% CI 1.464-3.307), respectively, for disease relapse.ConclusionsCombining TGF-β biomarkers provides prognostic information for patients with stage I-III breast cancer. This can identify patients at increased risk for disease recurrence that might therefore be candidates for additional treatment.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
de Kruijf, E M
-
Dekker, T J A
-
Hawinkels, L J A ...
-
Putter, H
-
Smit, V T H B M
-
Kroep, J R
-
visa fler...
-
Kuppen, P J K
-
van de Velde, C ...
-
ten Dijke, Peter
-
Tollenaar, R A E ...
-
Mesker, W E
-
visa färre...
- Artiklar i publikationen
-
Annals of Oncolo ...
- Av lärosätet
-
Uppsala universitet