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Sökning: WFRF:(van den Oord EJCG) > (2015-2019) > Genome-Wide Meta-An...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03727naa a2200493 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:131770613 | |
| 003 | SwePub | |
| 008 | 240913s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1317706132 URI |
| 024 | 7 | a https://doi.org/10.1017/thg.2015.362 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Adkins, DE4 aut |
| 245 | 1 0 | a Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood |
| 264 | c 2015-06-17 | |
| 264 | 1 | b Cambridge University Press (CUP),c 2015 |
| 520 | a The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to search for common genetic variants predicting developmental trajectories of alcohol consumption. Comparable psychiatric evaluations measuring alcohol consumption were collected in three longitudinal community samples (N = 2,126, obs = 12,166). Consumption-repeated measurements spanning adolescence and early adulthood were analyzed using linear mixed models, estimating individual consumption trajectories, which were then tested for association with Illumina 660W-Quad genotype data (866,099 SNPs after imputation and QC). Association results were combined across samples using standard meta-analysis methods. Four meta-analysis associations satisfied our pre-determined genome-wide significance criterion (FDR < 0.1) and six others met our ‘suggestive’ criterion (FDR <0.2). Genome-wide significant associations were highly biological plausible, including associations within GABA transporter 1, SLC6A1 (solute carrier family 6, member 1), and exonic hits in LOC100129340 (mitofusin-1-like). Pathway analyses elaborated single marker results, indicating significant enriched associations to intuitive biological mechanisms, including neurotransmission, xenobiotic pharmacodynamics, and nuclear hormone receptors (NHR). These findings underscore the value of combining longitudinal behavioral data and genome-wide genotype information in order to study developmental patterns and improve statistical power in genomic studies. | |
| 700 | 1 | a Clark, SL4 aut |
| 700 | 1 | a Copeland, WE4 aut |
| 700 | 1 | a Kennedy, M4 aut |
| 700 | 1 | a Conway, K4 aut |
| 700 | 1 | a Angold, A4 aut |
| 700 | 1 | a Maes, H4 aut |
| 700 | 1 | a Liu, YF4 aut |
| 700 | 1 | a Kumar, G4 aut |
| 700 | 1 | a Erkanli, A4 aut |
| 700 | 1 | a Patkar, AA4 aut |
| 700 | 1 | a Silberg, J4 aut |
| 700 | 1 | a Brown, TH4 aut |
| 700 | 1 | a Fergusson, DM4 aut |
| 700 | 1 | a Horwood, LJ4 aut |
| 700 | 1 | a Eaves, L4 aut |
| 700 | 1 | a van den Oord, EJCG4 aut |
| 700 | 1 | a Sullivan, PFu Karolinska Institutet4 aut |
| 700 | 1 | a Costello, EJ4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Twin research and human genetics : the official journal of the International Society for Twin Studiesd : Cambridge University Press (CUP)g 18:4, s. 335-347q 18:4<335-347x 1832-4274 |
| 773 | 0 | t Twin Research and Human Geneticsd : Cambridge University Press (CUP)g 18:4, s. 335-347q 18:4<335-347x 1839-2628 |
| 856 | 4 | u https://www.cambridge.org/core/services/aop-cambridge-core/content/view/ECEC7B12589BB0E58F50C44D1BBF560E/S1832427415000365a.pdf/div-class-title-genome-wide-meta-analysis-of-longitudinal-alcohol-consumption-across-youth-and-early-adulthood-div.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131770613 |
| 856 | 4 8 | u https://doi.org/10.1017/thg.2015.36 |
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