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Sökning: WFRF:(van der Mei Henny C.) > In vitro methods fo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004711naa a2200469 4500
001oai:DiVA.org:umu-146283
003SwePub
008180403s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1462832 URI
0247 a https://doi.org/10.1016/j.actbio.2018.02.0012 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sjollema, Jelmer4 aut
2451 0a In vitro methods for the evaluation of antimicrobial surface designs
264 1b Elsevier BV,c 2018
338 a print2 rdacarrier
520 a Bacterial adhesion and subsequent biofilm formation on biomedical implants and devices are a major cause of their failure. As systemic antibiotic treatment is often ineffective, there is an urgent need for antimicrobial biomaterials and coatings. The term “antimicrobial” can encompass different mechanisms of action (here termed “antimicrobial surface designs”), such as antimicrobial-releasing, contact-killing or non-adhesivity. Biomaterials equipped with antimicrobial surface designs based on different mechanisms of action require different in vitro evaluation methods. Available industrial standard evaluation tests do not address the specific mechanisms of different antimicrobial surface designs and have therefore been modified over the past years, adding to the myriad of methods available in the literature to evaluate antimicrobial surface designs. The aim of this review is to categorize fourteen presently available methods including industrial standard tests for the in vitro evaluation of antimicrobial surface designs according to their suitability with respect to their antimicrobial mechanism of action. There is no single method or industrial test that allows to distinguish antimicrobial designs according to all three mechanisms identified here. However, critical consideration of each method clearly relates the different methods to a specific mechanism of antimicrobial action. It is anticipated that use of the provided table with the fourteen methods will avoid the use of wrong methods for evaluating new antimicrobial designs and therewith facilitate translation of novel antimicrobial biomaterials and coatings to clinical use. The need for more and better updated industrial standard tests is emphasized. Statement of Significance European COST-action TD1305, IPROMEDAI aims to provide better understanding of mechanisms of antimicrobial surface designs of biomaterial implants and devices. Current industrial evaluation standard tests do not sufficiently account for different, advanced antimicrobial surface designs, yet are urgently needed to obtain convincing in vitro data for approval of animal experiments and clinical trials. This review aims to provide an innovative and clear guide to choose appropriate evaluation methods for three distinctly different mechanisms of antimicrobial design: (1) antimicrobial-releasing, (2) contact-killing and (3) non-adhesivity. Use of antimicrobial evaluation methods and definition of industrial standard tests, tailored toward the antimicrobial mechanism of the design, as identified here, fulfill a missing link in the translation of novel antimicrobial surface designs to clinical use.
650 7a NATURVETENSKAPx Kemix Annan kemi0 (SwePub)104992 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Other Chemistry Topics0 (SwePub)104992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng
653 a Biofilm
653 a Biomaterial-associated infection
653 a Antimicrobial-releasing
653 a Contact-killing
653 a Non-adhesive
7001 a Zaat, Sebastian A.J.4 aut
7001 a Fontaine, Veronique4 aut
7001 a Ramstedt, Madeleineu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)maerat95
7001 a Luginbuehl, Reto4 aut
7001 a Thevissen, Karin4 aut
7001 a Li, Jiuyi4 aut
7001 a van der Mei, Henny C.4 aut
7001 a Busscher, Henk J.4 aut
7102 a Umeå universitetb Kemiska institutionen4 org
7730 t Acta Biomaterialiad : Elsevier BVg 70, s. 12-24q 70<12-24x 1742-7061x 1878-7568
8564 u https://lirias.kuleuven.be/bitstream/123456789/614963/1/Sjollema%20review%202018.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146283
8564 8u https://doi.org/10.1016/j.actbio.2018.02.001

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