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Additional value of...
Additional value of magnetic resonance-targeted biopsies to standard transrectal ultrasound-guided biopsies for detection of clinically significant prostate cancer
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- von Below, Catrin, 1970- (author)
- Uppsala universitet,Radiologi
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- Wassberg, Cecilia (author)
- Uppsala universitet,Radiologi
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- Norberg, Mona (author)
- Uppsala universitet,Radiologi
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- Tolf, Anna (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Kullberg, Joel, 1979- (author)
- Uppsala universitet,Radiologi
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- Ladjevardi, Sam (author)
- Uppsala universitet,Urologkirurgi
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- Häggman, Michael (author)
- Uppsala universitet,Urologkirurgi
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- Bill-Axelson, Anna (author)
- Uppsala universitet,Urologkirurgi
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2017-02-24
- 2017
- English.
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In: Scandinavian journal of urology. - : Medical Journals Sweden AB. - 2168-1805 .- 2168-1813. ; 51:2, s. 107-113
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: The aim of this study was to evaluate the additional value of magnetic resonance imaging-targeted biopsy (MRI-TB) to standard transrectal ultrasound-guided biopsy (SB) for detection of clinically significant prostate cancer (PCa). An additional aim was to compare the biopsy results to MRI evaluation using a Likert scale.MATERIALS AND METHODS: Patients with newly diagnosed localized PCa (n = 53) by clinical routine SB were prospectively included. The majority of the patients were scheduled for curative therapy before enrollment. The patients underwent multiparametric MRI (mpMRI) at 3 T using an endorectal coil followed by two MRI-TBs, using ultrasound with cognitive fusion. All included patients underwent MRI-TB, even those who had low to very low suspicion of significant PCa on mpMRI. The detection rate of significant cancer on SB versus SB + MRI-TB was compared in the 53 included patients and with whole-mounted histopathology as reference in 34 cases. Comparison of the biopsy results to MRI evaluation and interreader agreement calculation of five-point Likert score evaluation were performed.RESULTS: In total, 32 significant (Gleason ≥7) PCa were detected by SB, while SB + MRI-TB detected an additional five significant PCa. MRI-TB alone detected 20 and missed 17 significant PCa. Ten of the significant PCa cases missed by MRI-TB had a Likert score of 3 or lower. Interreader agreement using the Likert scale was high, with a kappa value of 0.77 (95% confidence interval 0.63-0.92, p < 0.0001).CONCLUSION: Detection of significant PCa increased by adding MRI-TB to SB. This may not be of enough clinical value to justify the use of targeted biopsies in this patient group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Magnetic resonance imaging
- prostatic neoplasm
- targeted biopsies
- transrectal ultrasound-guided biopsy
Publication and Content Type
- ref (subject category)
- art (subject category)
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von Below, Catri ...
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Wassberg, Cecili ...
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Norberg, Mona
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Tolf, Anna
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Kullberg, Joel, ...
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Ladjevardi, Sam
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Häggman, Michael
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Bill-Axelson, An ...
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Ahlström, Håkan, ...
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Scandinavian jou ...
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Uppsala University