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Sökning: WFRF:(Haiman C) > (2010-2014) > Insulin-like growth...

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FältnamnIndikatorerMetadata
00004726naa a2200709 4500
001oai:DiVA.org:umu-94171
003SwePub
008141006s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-941712 URI
0247 a https://doi.org/10.1093/jnci/dju2182 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cao, Yin4 aut
2451 0a Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival
264 c 2014-05-14
264 1b Oxford University Press,c 2014
338 a print2 rdacarrier
500 a Errata JNCI-Journal of the National Cancer Institute (2014) 106 (6), dju085. DOI:10.1093/jnci/dju085
520 a BACKGROUND: The insulin-like growth factor (IGF) signaling pathway has been implicated in prostate cancer (PCa) initiation, but its role in progression remains unknown.METHODS: Among 5887 PCa patients (704 PCa deaths) of European ancestry from seven cohorts in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium, we conducted Cox kernel machine pathway analysis to evaluate whether 530 tagging single nucleotide polymorphisms (SNPs) in 26 IGF pathway-related genes were collectively associated with PCa mortality. We also conducted SNP-specific analysis using stratified Cox models adjusting for multiple testing. In 2424 patients (313 PCa deaths), we evaluated the association of prediagnostic circulating IGF1 and IGFBP3 levels and PCa mortality. All statistical tests were two-sided.RESULTS: The IGF signaling pathway was associated with PCa mortality (P = .03), and IGF2-AS and SSTR2 were the main contributors (both P = .04). In SNP-specific analysis, 36 SNPs were associated with PCa mortality with P-trend less than .05, but only three SNPs in the IGF2-AS remained statistically significant after gene-based corrections. Two were in linkage disequilibrium (r(2) = 1 for rs1004446 and rs3741211), whereas the third, rs4366464, was independent (r(2) = 0.03). The hazard ratios (HRs) per each additional risk allele were 1.19 (95% confidence interval [CI] = 1.06 to 1.34; P-trend = .003) for rs3741211 and 1.44 (95% CI = 1.20 to 1.73; P-trend < .001) for rs4366464. rs4366464 remained statistically significant after correction for all SNPs (P-trend.corr = .04). Prediagnostic IGF1 (HRhighest (vs lowest quartile) = 0.71; 95% CI = 0.48 to 1.04) and IGFBP3 (HR = 0.93; 95% Cl = 0.65 to 1.34) levels were not associated with PCa mortality.CONCLUSIONS: The IGF signaling pathway, primarily IGF2-AS and SSTR2 genes, may be important in PCa survival.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Lindström, Sara4 aut
7001 a Schumacher, Fredrick4 aut
7001 a Stevens, Victoria L.4 aut
7001 a Albanes, Demetrius4 aut
7001 a Berndt, Sonja I.4 aut
7001 a Boeing, Heiner4 aut
7001 a Bueno-de-Mesquita, H. Bas4 aut
7001 a Canzian, Federico4 aut
7001 a Chamosa, Saioa4 aut
7001 a Chanock, Stephen J.4 aut
7001 a Diver, W. Ryan4 aut
7001 a Gapstur, Susan M.4 aut
7001 a Gaziano, J. Michael4 aut
7001 a Giovannucci, Edward L.4 aut
7001 a Haiman, Christopher A.4 aut
7001 a Henderson, Brian4 aut
7001 a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France4 aut0 (Swepub:umu)masmas97
7001 a Le Marchand, Loïc4 aut
7001 a Palli, Domenico4 aut
7001 a Rosner, Bernard4 aut
7001 a Siddiq, Afshan4 aut
7001 a Stampfer, Meir4 aut
7001 a Stram, Daniel O.4 aut
7001 a Tamimi, Rulla4 aut
7001 a Travis, Ruth C.4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Willett, Walter C.4 aut
7001 a Yeager, Meredith4 aut
7001 a Kraft, Peter4 aut
7001 a Hsing, Ann W.4 aut
7001 a Pollak, Michael4 aut
7001 a Lin, Xihong4 aut
7001 a Ma, Jing4 aut
7102 a Umeå universitetb Enheten för biobanksforskning4 org
7730 t Journal of the National Cancer Instituted : Oxford University Pressg 106:5q 106:5x 0027-8874x 1460-2105
8564 u https://academic.oup.com/jnci/article-pdf/106/5/dju218/17985810/dju218.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-94171
8564 8u https://doi.org/10.1093/jnci/dju218

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