Greater pQCT Calf Muscle Density Is Associated with Lower Fracture Risk, Independent of FRAX, Falls and BMD: A Meta-Analysis in the Osteoporotic Fractures in Men (MrOS) Study

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Greater pQCT Calf Muscle Density Is Associated with Lower Fracture Risk, Independent of FRAX, Falls and BMD: A Meta-Analysis in the Osteoporotic Fractures in Men (MrOS) Study

Harvey, N. C. (författare): MRC Lifecourse Epidemiology Centre University of Southampton Southampton UK;NIHR Southampton Biomedical Research Centre University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK;NIHR Oxford Biomedical Research Centre University of Oxford Oxford UK

Orwoll, E. (författare): Division of Endocrinology, Diabetes and Clinical Nutrition, School of Medicine Oregon Health & Science University Portland OR USA

Cauley, J. A. (författare): Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh PA USA

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Kwok, T. (författare): Department of Medicine & Therapeutics and School of Public Health The Chinese University of Hong Kong Shatin China

Karlsson, Magnus K. (författare): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital

Rosengren, Björn E. (författare): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital

Ribom, Eva (författare): Uppsala University,Uppsala universitet,Ortopedi

Cawthon, P. M. (författare): Research Institute California Pacific Medical Center San Francisco CA USA;Department of Epidemiology and Biostatistics University of California San Francisco CA USA

Ensrud, K. (författare): Medicine and Epidemiology & Community Health University of Minnesota Minneapolis MN USA;Center for Care Delivery and Outcomes Research Minneapolis VA Health Care System Minneapolis MN USA

Liu, E. W. (författare): Mary MacKillop Institute for Health Research Australian Catholic University Melbourne Australia

Laskou, F. (författare): MRC Lifecourse Epidemiology Centre University of Southampton Southampton UK

Ward, K. A. (författare): MRC Lifecourse Epidemiology Centre University of Southampton Southampton UK

Dennison, E. M. (författare): MRC Lifecourse Epidemiology Centre University of Southampton Southampton UK,Centre for Metabolic Bone Diseases University of Sheffield Sheffield UK;Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Mellanby Centre for Musculoskeletal Research University of Sheffield Sheffield UK

Cooper, C. (författare)

Kanis, J. A. (författare): Mary MacKillop Institute for Health Research Australian Catholic University Melbourne Australia;Centre for Metabolic Bone Diseases University of Sheffield Sheffield UK

Vandenput, Liesbeth, 1974 (författare): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Mary MacKillop Institute for Health Research Australian Catholic University Melbourne Australia;Sahlgrenska Osteoporosis Centre, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Lorentzon, Mattias, 1970 (författare): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Mary MacKillop Institute for Health Research Australian Catholic University Melbourne Australia;Sahlgrenska Osteoporosis Centre, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Ohlsson, Claes, 1965 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Osteoporosis Centre, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Mellström, Dan, 1945 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Osteoporosis Centre, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Johansson, Helena, 1981 (författare): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Mary MacKillop Institute for Health Research Australian Catholic University Melbourne Australia;Sahlgrenska Osteoporosis Centre, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

McCloskey, E. (författare)

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2022-11-22
2022
Engelska.
Ingår i: JBMR Plus. - : Wiley. - 2473-4039. ; 6:12

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

We investigated the predictive performance of peripheral quantitative computed tomography (pQCT) measures of both calf muscle density (an established surrogate for muscle adiposity, with higher values indicating lower muscle adiposity and higher muscle quality) and size (cross-sectional area [CSA]) for incident fracture. pQCT (Stratec XCT2000/3000) measurements at the tibia were undertaken in Osteoporotic Fractures in Men (MrOS) United States (US), Hong Kong (HK), and Swedish (SW) cohorts. Analyses were by cohort and synthesized by meta-analysis. The predictive value for incident fracture outcomes, illustrated here for hip fracture (HF), using an extension of Poisson regression adjusted for age and follow-up time, was expressed as hazard ratio (HR) per standard deviation (SD) increase in exposure (HR/SD). Further analyses adjusted for femoral neck (fn) bone mineral density (BMD) T-score, Fracture Risk Assessment Tool (FRAX) 10-year fracture probability (major osteoporotic fracture) and prior falls. We studied 991 (US), 1662 (HK), and 1521 (SW) men, mean +/- SD age 77.0 +/- 5.1, 73.9 +/- 4.9, 80 +/- 3.4 years, followed for a mean +/- SD 7.8 +/- 2.2, 8.1 +/- 2.3, 5.3 +/- 2.0 years, with 31, 47, and 78 incident HFs, respectively. Both greater muscle CSA and greater muscle density were associated with a lower risk of incident HF [HR/SD: 0.84; 95% confidence interval [CI], 0.72-1.0 and 0.78; 95% CI, 0.66-0.91, respectively]. The pattern of associations was not materially changed by adjustment for prior falls or FRAX probability. In contrast, after inclusion of fn BMD T-score, the association for muscle CSA was no longer apparent (1.04; 95% CI, 0.88-1.24), whereas that for muscle density was not materially changed (0.69; 95% CI, 0.59-0.82). Findings were similar for osteoporotic fractures. pQCT measures of greater calf muscle density and CSA were both associated with lower incidence of fractures in older men, but only muscle density remained an independent risk factor for fracture after accounting for fn BMD. These findings demonstrate a complex interplay between measures of bone, muscle size, and quality, in determining fracture risk. (C) 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

epidemiology
fracture
frax
osteoporosis
peripheral quantitative
computed tomography
pqct
sarcopenia
cross-sectional area
physical performance
computed-tomography
hip-fractures
elderly-men
older men
bone
strength
women
determinants
Endocrinology & Metabolism
EPIDEMIOLOGY
FRACTURE
FRAX
OSTEOPOROSIS
PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY
PQCT
SARCOPENIA

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