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Working memory netw...
Working memory networks and activation patterns in schizophrenia and bipolar disorder : comparison with healthy controls
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- Lycke Brandt, Christine (författare)
- K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo
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- Eichele, Tom (författare)
- Department of Biological and Medical Psychology, University of Bergen
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- Melle, Ingrid (författare)
- K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo
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- Sundet, Kjetil (författare)
- Department of Psychology, University of Oslo
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- Server, Andrés (författare)
- Section of Neuroradiology, Department of Radiology and Nuclear Medicine, Oslo University Hospital
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- Agartz, Ingrid (författare)
- K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo
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- Hugdahl, Kenneth (författare)
- Department of Biological and Medical Psychology, University of Bergen
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- Jensen, Jimmy (författare)
- Högskolan Kristianstad,Avdelningen för Humanvetenskap
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- Andreassen, Ole A. (författare)
- K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo
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- Agartz, I (författare)
- Karolinska Institutet
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Andreassen, OA (författare)
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Jensen, J (författare)
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Melle, I (författare)
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Brandt, CL (författare)
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Sundet, K (författare)
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Server, A (författare)
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Eichele, T (författare)
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Hugdahl, K (författare)
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KG. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo Department of Biological and Medical Psychology, University of Bergen (creator_code:org_t)
- 2014
- 2014
- Engelska.
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Ingår i: British Journal of Psychiatry. - 0007-1250 .- 1472-1465. ; 204:4, s. 290-298
- Relaterad länk:
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https://www.cambridg...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: Schizophrenia and bipolar disorder are severe mental disorders with overlapping genetic and clinical characteristics, including cognitive impairments. An important question is whether these disorders also have overlapping neuronal deficits.AIMS: To determine whether large-scale brain networks associated with working memory, as measured with functional magnetic resonance imaging (fMRI), are the same in both schizophrenia and bipolar disorder, and how they differ from those in healthy individuals.METHOD: Patients with schizophrenia (n = 100) and bipolar disorder (n = 100) and a healthy control group (n = 100) performed a 2-back working memory task while fMRI data were acquired. The imaging data were analysed using independent component analysis to extract large-scale networks of task-related activations.RESULTS: Similar working memory networks were activated in all groups. However, in three out of nine networks related to the experimental task there was a graded response difference in fMRI signal amplitudes, where patients with schizophrenia showed greater activation than those with bipolar disorder, who in turn showed more activation than healthy controls. Secondary analysis of the patient groups showed that these activation patterns were associated with history of psychosis and current elevated mood in bipolar disorder.CONCLUSIONS: The same brain networks were related to working memory in schizophrenia, bipolar disorder and controls. However, some key networks showed a graded hyperactivation in the two patient groups, in line with a continuum of neuronal abnormalities across psychotic disorders.
Ämnesord
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
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- art (ämneskategori)
- Av författaren/redakt...
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Lycke Brandt, Ch ...
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Eichele, Tom
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Melle, Ingrid
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Sundet, Kjetil
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Server, Andrés
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Agartz, Ingrid
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visa fler...
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Hugdahl, Kenneth
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Jensen, Jimmy
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Andreassen, Ole ...
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Agartz, I
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Andreassen, OA
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Jensen, J
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Melle, I
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Brandt, CL
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Sundet, K
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Server, A
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Eichele, T
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Hugdahl, K
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Högskolan Kristianstad
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Karolinska Institutet