5-FU uptake in peritoneal metastases after pretreatment with radioimmunotherapy or vasoconstriction: an autoradiographic study in the rat

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Mahteme, HaileUppsala universitet,Gastrointestinalkirurgi (författare)

5-FU uptake in peritoneal metastases after pretreatment with radioimmunotherapy or vasoconstriction : an autoradiographic study in the rat

Artikel/kapitelEngelska2005

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2005
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LIBRIS-ID:oai:DiVA.org:uu-73650
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73650URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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This study was conducted to test if tumour drug uptake could be increased in experimental colorectal cancer peritoneal metastases, by using pretreatment with peritoneal vasoconstriction or radioimmunotherapy. A total of 29 nude rats with peritoneal metastases were injected intraperitoneally (i.p.) with 14C-labelled 5-FU. The animals were randomly allocated to 5 groups. Six days prior to 5-FU, group I (control) received i.p. NaCl, group II was subjected to i.p. radioimmunotherapy (RIT) 131I-labelled anti-CEA monoclonal antibody (150 MBq) and group III received i.p. Norbormide 10 minutes before 5-FU. Two days prior to 5-FU group IV and V received i.p. NaCl (control) and RIT, respectively. 5-FU uptake was visualised with autoradiography and quantified by computer-based image analysis. Tumours in group III showed a higher uptake (mean+/-SD, 21.4+/-17) than in group I (11.8+/-10, p=0.04). This was also true when the analysis was restricted to larger tumours (> or = median 627 pixels) group III (23.2+/-19) vs. group I (11.8+/-7, p=0.002). Peritoneal tumours in group II were of smaller size (median area 308 pixels) than in group I (619 pixels), in group III (901 pixels), in group IV (769 pixels) and in group V (808 pixels). RIT decreased the tumour size whereas it did not affect 5-FU uptake. The uptake of 5-FU was potentiated by pretreating the animals with Norbormide. These results demonstrate that 5-FU uptake in experimental peritoneal metastases is increased when the peritoneal absorption of the drug is blocked using pretreatment with a vasoconstrictive agent. This principle may also be relevant when treating patients with colorectal cancer peritoneal metastases.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
Adenocarcinoma/drug therapy/*metabolism/radiotherapy/*secondary
Animals
Antibodies; Monoclonal/immunology/pharmacology
Antimetabolites; Antineoplastic/*pharmacokinetics
Autoradiography
Carbon Radioisotopes/diagnostic use
Carcinoembryonic Antigen/immunology/pharmacology
Colonic Neoplasms/pathology
Female
Fluorouracil/*pharmacokinetics
Humans
Immunotoxins/*pharmacology
Iodine Radioisotopes/therapeutic use
Male
Norbornanes/*pharmacology
Peritoneal Cavity/*blood supply
Peritoneal Neoplasms/drug therapy/*metabolism/radiotherapy/*secondary
Radioimmunotherapy
Random Allocation
Rats
Research Support; Non-U.S. Gov't
Vasoconstriction/drug effects

Biuppslag (personer, institutioner, konferenser, titlar ...)

Sundin, AndersUppsala universitet,Enheten för radiologi(Swepub:uu)anderssu (författare)
Larsson, Bengt (författare)
Khamis, Harry (författare)
Arow, Kiril (författare)
Graf, WilhelmUppsala universitet,Kolorektalkirurgi(Swepub:uu)wilhgraf (författare)
Uppsala universitetGastrointestinalkirurgi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Anticancer Research25:2A, s. 917-9220250-70051791-7530

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Av författaren/redakt...: Mahteme, Haile; Sundin, Anders; Larsson, Bengt; Khamis, Harry; Arow, Kiril; Graf, Wilhelm

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

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Av lärosätet: Uppsala universitet

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