Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk

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Fältnamn	Indikatorer	Metadata
000		20455naa a2201297 4500
001		oai:DiVA.org:umu-198687
003		SwePub
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024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1986872 URI
024	7	a https://doi.org/10.1093/jnci/djac0942 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4895192 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1504860692 URI
040		a (SwePub)umud (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
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072	7	a art2 swepub-publicationtype
100	1	a Tian, Yuu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China4 aut
245	1 0	a Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk
264		c 2022-05-05
264	1	b Oxford University Press,c 2022
338		a print2 rdacarrier
520		a BACKGROUND: The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk. METHODS: We conducted a genome-wide, gene-environment interaction between single nucleotide polymorphisms and the use of any MHT, estrogen only, and combined estrogen-progestogen therapy with CRC risk, among 28 486 postmenopausal women (11 519 CRC patients and 16 967 participants without CRC) from 38 studies, using logistic regression, 2-step method, and 2- or 3-degree-of-freedom joint test. A set-based score test was applied for rare genetic variants. RESULTS: The use of any MHT, estrogen only and estrogen-progestogen were associated with a reduced CRC risk (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.64 to 0.78; OR = 0.65, 95% CI = 0.53 to 0.79; and OR = 0.73, 95% CI = 0.59 to 0.90, respectively). The 2-step method identified a statistically significant interaction between a GRIN2B variant rs117868593 and MHT use, whereby MHT-associated CRC risk was statistically significantly reduced in women with the GG genotype (OR = 0.68, 95% CI = 0.64 to 0.72) but not within strata of GC or CC genotypes. A statistically significant interaction between a DCBLD1 intronic variant at 6q22.1 (rs10782186) and MHT use was identified by the 2-degree-of-freedom joint test. The MHT-associated CRC risk was reduced with increasing number of rs10782186-C alleles, showing odds ratios of 0.78 (95% CI = 0.70 to 0.87) for TT, 0.68 (95% CI = 0.63 to 0.73) for TC, and 0.66 (95% CI = 0.60 to 0.74) for CC genotypes. In addition, 5 genes in rare variant analysis showed suggestive interactions with MHT (2-sided P < 1.2 × 10-4). CONCLUSION: Genetic variants that modify the association between MHT and CRC risk were identified, offering new insights into pathways of CRC carcinogenesis and potential mechanisms involved.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Kim, Andre E.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Bien, Stephanie A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Lin, Yiu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Qu, Conghuiu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Harrison, Tabitha A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Carreras-Torres, Robertu Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
700	1	a Díez-Obrero, Virginiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
700	1	a Dimou, Nikiu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700	1	a Drew, David A.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut
700	1	a Hidaka, Akihisau Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Huyghe, Jeroen R.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Jordahl, Kristina M.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States4 aut
700	1	a Morrison, Johnu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Murphy, Neilu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700	1	a Obón-Santacana, Mireiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
700	1	a Ulrich, Cornelia M.u Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut
700	1	a Ose, Jenniferu Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut
700	1	a Peoples, Anita R.u Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut
700	1	a Ruiz-Narvaez, Edward A.u Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States4 aut
700	1	a Shcherbina, Annau Biomedical Informatics Program, Department of Biomedical Data Sciences, Stanford University, CA, Stanford, United States4 aut
700	1	a Stern, Mariana C.u Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Su, Yu-Ruu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States4 aut
700	1	a van Duijnhoven, Franzel J Bu Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands4 aut
700	1	a Arndt, Volkeru Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700	1	a Baurley, James W.u Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut
700	1	a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut
700	1	a Bishop, D Timothyu Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom4 aut
700	1	a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700	1	a Buchanan, Daniel D.u Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia4 aut
700	1	a Chan, Andrew T.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States4 aut
700	1	a Figueiredo, Jane C.u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Gallinger, Stevenu Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada4 aut
700	1	a Gruber, Stephen B.u Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105
700	1	a Hoffmeister, Michaelu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700	1	a Jenkins, Mark A.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia4 aut
700	1	a Joshi, Amit D.u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States4 aut
700	1	a Keku, Temitope O.u Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States4 aut
700	1	a Larsson, Susanna C.u Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi4 aut0 (Swepub:uu)susla720
700	1	a Le Marchand, Loicu University of Hawaii Cancer Center, HI, Honolulu, United States4 aut
700	1	a Li, Liu Department of Family Medicine, University of Virginia, VA, Charlottesville, United States4 aut
700	1	a Giles, Graham G.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia4 aut
700	1	a Milne, Roger L.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia4 aut
700	1	a Nan, Hongmeiu Department of Global Health, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States4 aut
700	1	a Nassir, Ramiu Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia4 aut
700	1	a Ogino, Shujiu Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States4 aut
700	1	a Budiarto, Arifu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut
700	1	a Platz, Elizabeth A.u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut
700	1	a Potter, John D.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand4 aut
700	1	a Prentice, Ross L.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States4 aut
700	1	a Rennert, Gadu Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel4 aut
700	1	a Sakoda, Lori C.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States4 aut
700	1	a Schoen, Robert E.u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States4 aut
700	1	a Slattery, Martha L.u Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States4 aut
700	1	a Thibodeau, Stephen N.u Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States4 aut
700	1	a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99
700	1	a Visvanathan, Kalau Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut
700	1	a White, Emilyu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States4 aut
700	1	a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi4 aut0 (Swepub:uu)alwol516
700	1	a Woods, Michael O.u Memorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada4 aut
700	1	a Wu, Anna H.u Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Campbell, Peter T.u Department of Population Science, American Cancer Society, GA, Atlanta, United States4 aut
700	1	a Casey, Grahamu Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States4 aut
700	1	a Conti, David V.u Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Gunter, Marc J.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700	1	a Kundaje, Anshulu Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States4 aut
700	1	a Lewinger, Juan Pablou Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Moreno, Victoru Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain4 aut
700	1	a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States4 aut
700	1	a Pardamean, Bensu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut
700	1	a Thomas, Duncan C.u Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Tsilidis, Konstantinos K.u Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece4 aut
700	1	a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States4 aut
700	1	a Gauderman, W Jamesu Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States4 aut
700	1	a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Cancer Centre Hamburg (UCCH), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany4 aut
710	2	a Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, Chinab Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 org
773	0	t Journal of the National Cancer Instituted : Oxford University Pressg 114:8, s. 1135-1148q 114:8<1135-1148x 0027-8874x 1460-2105
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198687
856	4 8	u https://doi.org/10.1093/jnci/djac094
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489519
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:150486069

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Av författaren/redakt...: Tian, Yu; Kim, Andre E.; Bien, Stephanie ...; Lin, Yi; Qu, Conghui; Harrison, Tabith ...; visa fler...; Carreras-Torres, ...; Díez-Obrero, Vir ...; Dimou, Niki; Drew, David A.; Hidaka, Akihisa; Huyghe, Jeroen R ...; Jordahl, Kristin ...; Morrison, John; Murphy, Neil; Obón-Santacana, ...; Ulrich, Cornelia ...; Ose, Jennifer; Peoples, Anita R ...; Ruiz-Narvaez, Ed ...; Shcherbina, Anna; Stern, Mariana C ...; Su, Yu-Ru; van Duijnhoven, ...; Arndt, Volker; Baurley, James W ...; Berndt, Sonja I.; Bishop, D Timoth ...; Brenner, Hermann; Buchanan, Daniel ...; Chan, Andrew T.; Figueiredo, Jane ...; Gallinger, Steve ...; Gruber, Stephen ...; Harlid, Sophia, ...; Hoffmeister, Mic ...; Jenkins, Mark A.; Joshi, Amit D.; Keku, Temitope O ...; Larsson, Susanna ...; Le Marchand, Loi ...; Li, Li; Giles, Graham G.; Milne, Roger L.; Nan, Hongmei; Nassir, Rami; Ogino, Shuji; Budiarto, Arif; Platz, Elizabeth ...; Potter, John D.; Prentice, Ross L ...; Rennert, Gad; Sakoda, Lori C.; Schoen, Robert E ...; Slattery, Martha ...; Thibodeau, Steph ...; van Guelpen, Bet ...; Visvanathan, Kal ...; White, Emily; Wolk, Alicja; Woods, Michael O ...; Wu, Anna H.; Campbell, Peter ...; Casey, Graham; Conti, David V.; Gunter, Marc J.; Kundaje, Anshul; Lewinger, Juan P ...; Moreno, Victor; Newcomb, Polly A ...; Pardamean, Bens; Thomas, Duncan C ...; Tsilidis, Konsta ...; Peters, Ulrike; Gauderman, W Jam ...; Hsu, Li; Chang-Claude, Je ...; visa färre...

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