Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Gastroenterologi) > Microbiome-derived ...
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000 | 06704naa a2200841 4500 | |
001 | oai:gup.ub.gu.se/320846 | |
003 | SwePub | |
008 | 240910s2022 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:ce3c652a-ff62-45d7-8727-d279ec846a6c | |
024 | 7 | a https://gup.ub.gu.se/publication/3208462 URI |
024 | 7 | a https://doi.org/10.1038/s41591-022-02016-62 DOI |
024 | 7 | a https://research.chalmers.se/publication/5326102 URI |
040 | a (SwePub)gud (SwePub)cth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Meijnikman, A. S.u Spaarne Gasthuis,Spaarne Hospital,Universiteit Van Amsterdam,University of Amsterdam4 aut |
245 | 1 0 | a Microbiome-derived ethanol in nonalcoholic fatty liver disease |
264 | c 2022-10-10 | |
264 | 1 | b Springer Science and Business Media LLC,c 2022 |
520 | a A new study examines microbiome-generated ethanol in individuals with and without nonalcoholic fatty liver disease (NAFLD), concluding that microbial ethanol might contribute to pathogenesis in some patients with NAFLD. To test the hypothesis that the gut microbiota of individuals with nonalcoholic fatty liver disease (NAFLD) produce enough ethanol to be a driving force in the development and progression of this complex disease, we performed one prospective clinical study and one intervention study. Ethanol was measured while fasting and 120 min after a mixed meal test (MMT) in 146 individuals. In a subset of 37 individuals and in an external validation cohort, ethanol was measured in portal vein blood. In an intervention study, ten individuals with NAFLD and ten overweight but otherwise healthy controls were infused with a selective alcohol dehydrogenase (ADH) inhibitor before an MMT. When compared to fasted peripheral blood, median portal vein ethanol concentrations were 187 (interquartile range (IQR), 17-516) times higher and increased with disease progression from 2.1 mM in individuals without steatosis to 8.0 mM in NAFL 21.0 mM in nonalcoholic steatohepatitis. Inhibition of ADH induced a 15-fold (IQR,1.6- to 20-fold) increase in peripheral blood ethanol concentrations in individuals with NAFLD, although this effect was abolished after antibiotic treatment. Specifically, Lactobacillaceae correlated with postprandial peripheral ethanol concentrations (Spearman's rho, 0.42; P < 10(-5)) in the prospective study. Our data show that the first-pass effect obscures the levels of endogenous ethanol production, suggesting that microbial ethanol could be considered in the pathogenesis of this highly prevalent liver disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
653 | a alcohol | |
653 | a steatosis | |
653 | a fermentation | |
653 | a pathogenesis | |
653 | a metabolism | |
653 | a benefits | |
653 | a glucose | |
653 | a mice | |
653 | a Biochemistry & Molecular Biology | |
653 | a Cell Biology | |
653 | a Research & Experimental | |
653 | a Medicine | |
700 | 1 | a Davids, M.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Herrema, H.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Aydin, O.u Universiteit Van Amsterdam,University of Amsterdam,Spaarne Gasthuis,Spaarne Hospital4 aut |
700 | 1 | a Tremaroli, Valentina,d 1978u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xtreva |
700 | 1 | a Rios-Morales, M.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Levels, H.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Bruin, S.u Spaarne Gasthuis,Spaarne Hospital4 aut |
700 | 1 | a de Brauw, M.u Spaarne Gasthuis,Spaarne Hospital4 aut |
700 | 1 | a Verheij, J.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Kemper, M.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Holleboom, A. G.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Tushuizen, M. E.u Universiteit Leiden (UL),Leiden University (UL)4 aut |
700 | 1 | a Schwartz, T. W.u Köpenhamns universitet,University of Copenhagen4 aut |
700 | 1 | a Nielsen, Jens B,d 1962u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)nielsenj |
700 | 1 | a Brandjes, D.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Dirinck, E.4 aut |
700 | 1 | a Weyler, J.4 aut |
700 | 1 | a Verrijken, A.u Universiteit Van Amsterdam,University of Amsterdam,Spaarne Gasthuis,Spaarne Hospital4 aut |
700 | 1 | a De Block, C. E. M.4 aut |
700 | 1 | a Vonghia, L.4 aut |
700 | 1 | a Francque, S.4 aut |
700 | 1 | a Beuers, U.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Gerdes, V. E. A.4 aut |
700 | 1 | a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Köpenhamns universitet,University of Copenhagen4 aut0 (Swepub:gu)xbafre |
700 | 1 | a Groen, A. K.u Universiteit Van Amsterdam,University of Amsterdam4 aut |
700 | 1 | a Nieuwdorp, M.u Spaarne Gasthuis,Spaarne Hospital,Universiteit Van Amsterdam,University of Amsterdam4 aut |
710 | 2 | a Spaarne Gasthuisb Universiteit Van Amsterdam4 org |
773 | 0 | t Nature Medicined : Springer Science and Business Media LLCg 28:10, s. 2100-2106q 28:10<2100-2106x 1078-8956x 1546-170X |
856 | 4 8 | u https://gup.ub.gu.se/publication/320846 |
856 | 4 8 | u https://doi.org/10.1038/s41591-022-02016-6 |
856 | 4 8 | u https://research.chalmers.se/publication/532610 |
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