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Head-to-head compar...
Head-to-head comparison of relevant cell sources of small extracellular vesicles for cardiac repair : Superiority of embryonic stem cells
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- González-King, Hernán (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Rodrigues, Patricia G. (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Albery, Tamsin (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Tangruksa, Benyapa (author)
- Gothenburg University,Göteborgs universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,Translational Bioinformatics,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Gurrapu, Ramya (author)
- AstraZeneca India Private Limited, Neville Tower 11th Floor, Ramanujan IT SEZ, Rajv Gandhi Salai (OMR), Taramani, Tamil Nadu, Chennai, India
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- Silva, Andreia M. (author)
- Discovery Sciences, Oligo Assay Development, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden ; Anjarium Biosciences AG, Schlieren, Switzerland
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- Musa, Gentian (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Kardasz, Dominika (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Liu, Kai (author)
- Discovery Sciences, Oligo Assay Development, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden ; Pharmaceutical Sciences, Advanced Drug Delivery, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Kull, Bengt (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Åvall, Karin (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Rydén-Markinhuhta, Katarina (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Incitti, Tania (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Sharma, Nitin (author)
- AstraZeneca India Private Limited, Neville Tower 11th Floor, Ramanujan IT SEZ, Rajv Gandhi Salai (OMR), Taramani, Tamil Nadu, Chennai, India
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- Graneli, Cecilia (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Valadi, Hadi, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Petkevicius, Kasparas (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Carracedo, Miguel (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Tejedor, Sandra (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden,Translational Bioinformatics
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- Ivanova, Alena (author)
- Discovery Sciences, Oligo Assay Development, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Heydarkhan-Hagvall, Sepideh (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Chief Medical Office, Global Patient Safety, AstraZeneca, Mölndal, Sweden,Translational Bioinformatics
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- Menasché, Phillipe (author)
- Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, Université de Paris, PARCC, INSERM, Paris, France
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- Synnergren, Jane (author)
- Gothenburg University,Göteborgs universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,Translational Bioinformatics,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Dekker, Niek (author)
- Discovery Sciences, Oligo Assay Development, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Wang, Quing -Dong (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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- Jennbacken, Karin (author)
- Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Sweden
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- English.
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In: Journal of Extracellular Vesicles. - : John Wiley & Sons. - 2001-3078. ; 13:5
- Related links:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Small extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial infarction (MI). The aim of this study was to compare different sources of sEV for cardiac repair and determine the most effective one, which nowadays remains limited. We comprehensively assessed the efficacy of sEV obtained from human primary bone marrow mesenchymal stromal cells (BM-MSC), human immortalized MSC (hTERT-MSC), human embryonic stem cells (ESC), ESC-derived cardiac progenitor cells (CPC), human ESC-derived cardiomyocytes (CM), and human primary ventricular cardiac fibroblasts (VCF), in in vitro models of cardiac repair. ESC-derived sEV (ESC-sEV) exhibited the best pro-angiogenic and anti-fibrotic effects in vitro. Then, we evaluated the functionality of the sEV with the most promising performances in vitro, in a murine model of MI-reperfusion injury (IRI) and analysed their RNA and protein compositions. In vivo, ESC-sEV provided the most favourable outcome after MI by reducing adverse cardiac remodelling through down-regulating fibrosis and increasing angiogenesis. Furthermore, transcriptomic, and proteomic characterizations of sEV derived from hTERT-MSC, ESC, and CPC revealed factors in ESC-sEV that potentially drove the observed functions. In conclusion, ESC-sEV holds great promise as a cell-free treatment for promoting cardiac repair following MI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- angiogenesis
- fibrosis
- immunomodulation
- myocardial ischaemia-reperfusion injury
- regeneration
- small extracellular vesicles
- adverse outcome
- antifibrotic activity
- Article
- BMSC cell line
- cardiac muscle cell
- cardiac stem cell
- cell function
- cell therapy
- clinical effectiveness
- controlled study
- down regulation
- exosome
- fibroblast
- heart surgery
- human
- human cell
- human embryonic stem cell
- immortalized cell line
- in vitro study
- in vivo study
- myocardial ischemia reperfusion injury
- outcome assessment
- protein content
- proteomics
- RNA analysis
- transcriptomics
- Bioinformatik
- Bioinformatics
- angiogenesis
- fibrosis
- immunomodulation
- myocardial ischaemia-reperfusion injury
- regeneration
- small extracellular vesicles
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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González-King, H ...
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Rodrigues, Patri ...
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Albery, Tamsin
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Tangruksa, Benya ...
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Gurrapu, Ramya
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Silva, Andreia M ...
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show more...
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Musa, Gentian
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Kardasz, Dominik ...
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Liu, Kai
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Kull, Bengt
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Åvall, Karin
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Rydén-Markinhuht ...
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Incitti, Tania
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Sharma, Nitin
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Graneli, Cecilia
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Valadi, Hadi, 19 ...
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Petkevicius, Kas ...
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Carracedo, Migue ...
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Tejedor, Sandra
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Ivanova, Alena
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Heydarkhan-Hagva ...
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Menasché, Philli ...
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Synnergren, Jane
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Dekker, Niek
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Wang, Quing -Don ...
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Jennbacken, Kari ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Journal of Extra ...
- By the university
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University of Skövde
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University of Gothenburg